(3/n) Do mitotic microcompartments have a transcriptional function? Prior work from @chrishsiung.bsky.social Gerd Blobel discovered 'mitotic transcriptional spiking', where ~half of genes transcriptionally spike in mitosis. We now show that microcompartment dot number and strength predicts spiking

Congrats to the twitterless (and Bluesky-less) Haoyue Zhang for a phenomenal paper recently published in Nature. An impressive combination of acute degradation experiments reveals the mutual influences that different SMC complexes have on 3D genome folding www.nature.com/articles/s41...

Recently joined Bluesky, so sharing here. Our latest work on bioRxiv. Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer-promoter interactions can form de novo without loop extrusion. www.biorxiv.org/content/10.1...