Questions about becoming an #ALZFunded researcher? Stop by Booth 1010 in the #AAIC25 Exhibition Hall today through Wednesday, 10:30 a.m.- 4:15 p.m., for more information on how we support dementia scientists throughout the field.

🏆 Bart de Strooper, M.D., Ph.D., is the recipient of the Khalid Iqbal Lifetime Achievement Award. #AAIC25 @ucl.ac.uk‬ @cbdresearch.bsky.social @ukdri.ac.uk

Welcome to all of those joining us in-person in Toronto for #AAIC25! We're looking forward to a week of networking, collaboration and learning both virtually and in "The 6ix." 🍁🦫

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Unlock the power of past Alzheimer's clinical trials! 🧠 Drs. Mark Dubbelman and Sietske Sikkes join the ISTAART Voices podcast to explore how better access to trial data can improve patient stratification for disease-modifying therapies in Alzheimer’s research and care! 🎧alz.org/ISTAARTpodcast

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

Collaborate with top researchers from around the 🌍 and help propel the next wave of progress in dementia science at #AAIC25, July 27 - 31 in Toronto, Canada, and online. Early-bird registration closes May 16. Register now to save: alz.org/aaic.

Delighted to welcome our new class of ISTAART Ambassadors for 2025! This year's 43 Ambassadors represent 27 countries across the globe. They'll work with us at #AAIC25 Toronto & online & we'll be mentoring them over the next year! Meet them at alz.org/ISTAARTambassadors @alzassociation.bsky.social

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾 journals.plos.org/plosgenetics... More to come from Aydan soon!

Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". www.cell.com/cell-reports... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko See below for details and preprint

‼️🚨⚠️ New @alz.org grant announcement! ADSF: Vascular Contributions to Cognitive Impairment and Dementia - Understanding Mechanisms of Dysfunction (VCID-UMD) is now OPEN! LOI deadline: May 30, 2025 5 pm ET/USA @istaart.bsky.social alz.org/research/for_researchers/grants/types-of-grants/vcid-umd

Congratulations to Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍 www.sciencedirect.com/science/arti...

Nice highlight on the incredible work of @malutansey.bsky.social and team! #goteamstark medicine.iu.edu/blogs/resear...

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...

📢Tune in to ISTAART Voices! Drs. Gregory Jicha and Peter Nelson compare emerging anti-amyloid therapies to biologics used in cancer and other diseases. This conversation highlights novel therapies transforming Alzheimer's treatment! Listen now at alz.org/ISTAARTpodca...! 🎧

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease @naturemedicine.bsky.social www.nature.com/articles/s41...

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

The highlight of #AAIC APOE and lipid biology? @liddelowsa.bsky.social and @oihaneuh.bsky.social seem to think so! 🥰🦭

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease www.nature.com/articles/s41...

Excited to be part of the work-"A high-throughput assay platform to discover small molecule activators of the phospholipase PLCG2 to treat Alzheimer’s disease"- now out in JBC ! Huge thanks to Qisheng and the team for this amazing collaborators! www.jbc.org/article/S002...

Excited to be in #Pittsburgh for the @alzassociation.bsky.social #AAICNeuroNext conference. This hybrid global conference is free and run in parallel in Barcelona, Belgrade, Buenos Aires, Ibadan, Indianapolis, Nairobi, New Delhi, Pittsburgh, Porto Alegre, Santiago, Thessaloniki, and Yaoundé!

Dive into the complex relationship between Alzheimer's and Lewy body pathologies with Dr. Duygu Tosun on the latest episode of ISTAART Voices! Discover how cutting-edge research is paving the way for innovative treatments. New episode, out now at alz.org/ISTAARTpodcasts @alzassociation.bsky.social

The ISTAART Ambassador Program is still open for applications! Hear what the current cohort has to say about the program, what it meant to them, and why you should apply! www.youtube.com/watch?v=Y_7-...

📢 CUT&Tag version 3 Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript: www.biorxiv.org/content/10.1...

AAIC Award Nominations are open. Submit a nomination today for the AAIC Lifetime Achievement Awards, the Bill Thies Award for Distinguished Service to ISTAART and the Inge Grundke-Iqbal Award for Alzheimer's Research. aaic.alz.org/about/awards...

Did you catch the latest episode of ISTAART Voices? Dr. Dana Pourzinal shared new research on the diverse cognitive profiles of Parkinson's disease, shedding light on subtypes of cognitive decline and potential for earlier intervention. Listen now! open.spotify.com/show/16aooAT...

ISTAART members! Have you submitted your work to #AAIC25 yet? Abstract submissions are extended till Jan 31 for members, so submit yours today! alz.org/AAIC

🚨 ISTAART Voices is back! 🎉 Join us as we chat with scientists about their groundbreaking work from the Alzheimer’s & Dementia journal family. Tune in on your favorite podcast platforms, or visit alz.org/ISTAARTpodcasts! 🎧

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease www.nature.com/articles/s41...

This week in #Science #Immunology: Lukas Amann, Marco Prinz, & colleagues at @uni-freiburg.de report that #extrasinusoidal #macrophages in the #mouse #DuraMater represent a distinct subset of #CNS -associated macrophages whose role is shaped by #autoimmune #neuroinflammation! #neuroimmunology

new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

💘 Celebrate Valentine’s Day with cutting-edge science on APOE and lipid droplets! Join the ImmunityPIA webinar on 2/14/2025! 🎤 Speakers: @cohenlaboratory.bsky.social Dr. Xu Chen 🌟 Panelists: Dr. Kimberley Bruce Dr. Lance Johnson 👉 Register now: alz-org.zoom.us/webinar/regi... Don’t miss it!

Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪 #neuroskyence nature.com/articles/s4159…

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

Abstract submissions for #AAICAdvancements: APOE & Lipid Biology, and #Tau2025 close Dec. 6 for ISTAART members! Share your work on APOE’s role in neurodegeneration or tauopathies like PSP, CBD & FTD. Don’t miss out on these two meetings—Submit now! www.alz.org/research/for...