We are happy to announce the recount3 tracks for hg38 and mm10: uniformly processed RNA-seq data from multiple studies, featuring intron data, split read counts, and splice junction motifs for cross-study comparisons and meta-analyses. Learn more at: bit.ly/recount3_track

"Choosing problems is the primary determinant of what one accomplishes in science." 'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists. pni.princeton.edu/document/1136

EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them.

'Evidence suggesting that #microglia make #amyloid from neuronally expressed APP: a hypothesis' John Hardy & Patrick Lewis molecularneurodegeneration.biomedcentral.com/articles/10....

With so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️ We are all fighting for you @curemaptftd.bsky.social 💙 go.bsky.app/KHno2VG

Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...

www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...

Nice to see this finally published! Congratulations @jack-humphrey.bsky.social www.nature.com/articles/s41... (Collaborative work with Panos Roussos and his team! ) Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

This is important! Satellite rallies too! Going sends a message. Not going also sends a message. It's not self-serving for scientists to protest the war on science. Millions of people depend on us. A huge thank you to the early career scientists who are leading this! 🧪 #standupforscience

The Genomic Code: the genome instantiates a generative model of the organism www.cell.com/trends/genet... - really delighted to see this in print in @cp-trendsgenetics.bsky.social! 😊

I fear that my crew of junior scientists are going to be absolutely decimated. We did postdocs during the pandemic (I had a 1.5 year old with no childcare!). Somehow, we got through that only to be met with an unprecedented freezing of the NIH.

If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:

🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers engineering.stanford.edu/news/future-...

I've had a fantastic week in London meeting old friends and new back at Queen Square #UCL. Thanks to @adrianisaacs.bsky.social and @frattalab.bsky.social for letting me crash their Christmas parties and Johh Hardy for inviting me to give a talk.