Marta Olah, PhD
@martikacska.bsky.social
📤 352
đź“Ą 154
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Assistant Professor at CUMC, neuroscientist, microgliologist, mom, wife
there is still time to register - come join us at this ISTAART Immersive at AAIC2026 in London with @FalakSh48753148
7 days ago
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for those of you interested in CRISPR tools and microglia functional genomics - check out the newest preprint from the Sher lab 🙂 @FalakSh48753148
pubmed.ncbi.nlm.nih.gov/42182403/
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AI platform for CRISPR functional mapping and function-based drug design - PubMed
Conventional structure-based drug design has high clinical failure rates due to the disconnect where binding affinity does not guarantee safe functional modulation. To bridge this gap, we present CRIS...
https://pubmed.ncbi.nlm.nih.gov/42182403/
9 days ago
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Happy to share the newest microglia functional genomics paper from the Sher lab!
link.springer.com/article/10.1...
Congratulations to all involved including
@nainikaroy.bsky.social
@FalakSh48753148
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Alzheimer’s disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons - Acta Neuropathologica
Microglial dysfunction is a hallmark of Alzheimer’s disease (AD), yet the molecular mechanisms driving these impairments remain poorly defined. Genetic studies implicate several AD-associated genes in...
https://link.springer.com/article/10.1007/s00401-026-03002-9
2 months ago
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our ALS study finally found its home
link.springer.com/article/10.1...
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Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord - Acta Neuropathologica
Development of therapeutic approaches that target specific microglia responses in amyotrophic lateral sclerosis (ALS) is crucial due to the involvement of microglia in ALS progression. Our study ident...
https://link.springer.com/article/10.1007/s00401-025-02913-3
10 months ago
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Super excited to be here and to start using this platform with a great news - check out the latest study from the Sher lab published in Acta Neuropathologica reporting on the effect of LINE-1 retrotransposons on microglial function in Alzheimer’s disease 🙂
link.springer.com/article/10.1...
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Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction - Acta Neuropathologica
Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...
https://link.springer.com/article/10.1007/s00401-024-02835-6
over 1 year ago
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