"Theatricality and deception - powerful agents to the uninitiated." "Oh, you think darkness is your ally." "The shadows betray you because they belong to me." Joe Marler was the ONLY one that worked it out #CelebrityTraitors

trickle down economics trickle down economic trickle down economi trickle down econom trickle down econo trickle down econ trickle down eco trickle down ec trickle down e trickle down trickle dow trickle do trickle d trickle trickl trick

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.08.25.671921v1

TDP-43 loss of function drives aberrant splicing in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.04.673943v1

Dear Friends and Colleagues, we are finally on Bluesky! Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy. We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/

Well that was a great idea, a stage organised by @johnkennedydj.bsky.social @radiox.co.uk @themaccabees.bsky.social @allpointseastfest.bsky.social #AllPointsEast featuring Man/Woman/Chainsaw amongst others

The calm before the storm @themaccabees.bsky.social @allpointseastfest.bsky.social @radiox.co.uk #AllPointsEast #Maccabees

Excited to share my new book with you. Out now for pre-order: www.penguin.co.uk/books/458539...

New from the Kinghorn Lab! 🧠🔬 Our latest preprint shows that in fly 🪰🧬 Gaucher’s & Parkinson’s 🧠 models, kidney dysfunction drives neurodegeneration - supporting emerging links between renal health & Parkinson's. You can read it here: www.biorxiv.org/content/10.1...

Blood Biomarkers: Testing for Alzheimer’s Disease Professor Jonathan Schott @jmschott.bsky.social (UCL) explains how blood tests are reshaping Alzheimer’s diagnosis. Clear, current and clinically relevant. Recorded at the Wessex Dementia Research Conference youtu.be/3fLl1Mzwbsk

Another fulfilling week for The Greensmith Lab (+ colleagues from other DNMD groups) hosting their annual Work Experience at UCL QSIoN. The Summer Students were able to get a taste of scientific life, with hands-on experience, learning key skills eg. pipetting, cell culture, immunostaining and more!

Congratulations to all colleagues that have worked hard to support the scientific community, and that have been recognised for their efforts. Senior Academic and Early Career Promotions 2024-25 | UCL Faculty of Brain Sciences @uclqsion.bsky.social www.ucl.ac.uk/brain-scienc...

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge. jobs.cam.ac.uk/job/52026/ jobs.cam.ac.uk/job/52027/

Cerebral small vessel disease (cSVD) can cause stroke and dementia, but has no cure. With @ukdri.ac.uk, we're supporting a clinical study at @imperialcollegeldn.bsky.social to test whether XBD173, a shelved anxiety drug, can reduce brain damage in people with cSVD.

It's cool to live in a country when the Women are better at football than the men #WEURO2025 #Lionesses #EnglandItaly

New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits. www.biorxiv.org/content/10.1...

Nonuniversality of inflammaging across human populations www.nature.com/articles/s43...

"Age is just a number, attitude is everything" Fauja Singh is world's oldest marathon runner, & local and national hero and inspiration. Took up running at age of 89 against grief of losing his wife and son. Raised thousands of pounds for charity www.itv.com/news/2025-07...

Research Assistant position at King’s College London. Join the PALLDEM-Homecare project to support homecare for people with dementia. Qualitative research skills required. Closing date: 27th July www.dementiaresearcher.nihr.ac.uk/job/research...

The pick of the London festivals @themaccabees.bsky.social ##AllPointsEast Now with @johnkennedydj.bsky.social @radiox.co.uk stage

Working with tricky colleagues? Join us at 12pm BST on Weds 16 July for tips on handling conflict in research with Dr Claire Price & Dr Anna Mallach. Live talk & chat. communities.dementiaresearcher.nihr.ac.uk/c/events/wor...

Amazing opportunity postdocs

What is the link between rugby and dementia? A new study of 200 former players aged 30-61, led by Prof David Sharp & Dr Neil Graham, found no cases of early-onset dementia, although some of the group showed potential signs of neurodegeneration👉 buff.ly/JulcQyL

Happy to have played a small part in testing this next generation of blood biomarker tests across different dementias: Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Research Assistant at UCL Institute of Neurology, London. Join Professor Joanne Ng’s team on a gene therapy project for Parkinson’s, using in vivo models of neurodegeneration. Closing date: 20th July www.dementiaresearcher.nihr.ac.uk/job/research...

Professor Mike Hanna will be leading the UCL IoN CNMD Team in fundraining for @BrainAppeal in the Saucony London 10K race on July 13, 2025. Please donate what you can! www.justgiving.com/page/the-nat... Please repost/share

It's out! More than just making amyloid? What if mutations in PSEN1 also predispose inflammation. We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....

In this interview with the @dailyrecord.co.uk, Professor @jmschott.bsky.social (@uclqsion.bsky.social) shares six top tips to boost your brain health. 🧠 ✨

First post on Bluesky— We identify two IFN-inducible lncRNAs as endogenous MDA5 ligands forming an RNA–sensor feedback loop that sustains innate immunity. m⁵C + ALY/REF = cytoplasmic targeting switch Read more www.researchsquare.com/article/rs-6... #InnateImmunity #lncRNA #MDA5 #Autoimmunity

Amazing to bring researchers from around the world together with CURE-ND for the first Stem Cell Models of Neurodegeneration (SCMND) Conference in Edinburgh earlier this year 🧠 Video round-up 📽️ youtu.be/9wMRndMVbQM?... Conference blog 👉 www.ukdri.ac.uk/news-and-eve...

1- In "Slow Horses," Apple TV+ series based on Mick Herron's novels, Jonathan Pryce sensitively depicts a retired spy who has developed #dementia. He drew on his experience playing similar roles & serving as an ambassador for the UK Alzheimer’s Society. thecontending.com/jonathan-pry...

When this WhatsApp arrives on a Sunday eve with no explanation it can only mean be thing… your US co-convener has arrived & Molecular Neurodegeneration starts tomorrow! Excited to meet this years cohort 🧬 🧫 🧪

Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

New paper from the lab, under the leadership of @celarber.bsky.social !

They found me #MassiveAttack trialing Elon's Neuralink at their show. Identified me as a hacker #LIDO

Adore #MassiveAttack for their music, Love them for their conscience! Playing with #47Soul & #Air They will be on the right side of history. Amazing evening #LIDO

Neuroinflammation across neurological diseases @science.org www.science.org/doi/10.1126/...

Team GP2 implemented Population Attributable Risk comparisons on PD risk loci across multiple ancestral populations and found that attributable risk varied across populations. 🔗 Read Team GP2's #preprint: www.medrxiv.org/content/10.1...

If you are looking for a PhD, are passionate about neurobiology and enjoy microscopy, come and join us for a PhD project on axonal pathophysiology in ALS! www.findaphd.com/phds/project... Applications close on Friday 4th July 2025 @mndassoc.bsky.social @uclqsion.bsky.social

When you realise the symposium closed captioning is transcribing what you’re saying even though you’re at the back of the room and not wearing a microphone 🫣🫣🫠🫠

It's a pleasure to welcome a new Group Leader to the UK DRI! 🙌 🎉 🥳 Prof @pareshmalhotra.bsky.social joins our Care Research & Tech Centre to harness new opportunities & trial data to transform the way that dementia treatments are evaluated Read more 👉 www.ukdri.ac.uk/news-and-eve...

New Skeetorial time! 🦋 A new preprint led by Dr. #MinhooKim, where we present the characterization of #mouse models of #menopause using a combination of histology, endocrine measures, single-cell #transcriptomics, and #RNAscope validation! #GeroSky 🧪🖥️🧬 A 🧵 1/9 www.biorxiv.org/content/10.1...

This was predicted 20 years ago

We are happy to seek 3 post-docs across Edinburgh Napier, Glasgow & UCL in an exciting project to investigate mechanisms linking glial ageing/longevity & neurodegeneration (MRC-funded). Info attached @nathanwoodling.bsky.social @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social

A nice read and ICYMI here is our cited paper from the end of last year on the microglia contribution to Familial British Dementia: link.springer.com/article/10.1...

Hi! Our lab investigates what regulates CNS myelin development, damage & regeneration with implications for neurological conditions e.g. MS, AD and cognitive decline. Using 'omics, transgenics & human neuropath. Focus on immune-glial interactions. Soft spot for microglia & women/ diversity in STEM.

Great to be at the first #FGx2025 meeting for the UK Human Functional Genomics Initiative at Exeter @uk-fgx.bsky.social So much exciting genomics taking off...a new age @exeter.ac.uk @mrcmousenetwork.bsky.social @jonathanmill.bsky.social

A chemotherapy-free combination approach to treating leukaemia may lead to better outcomes for some patients, with the results being hailed as a “milestone”. The Flair trial took place at 96 cancer centres across the UK. 🧪💊🩸 #medsky www.theguardian.com/science/2025...