New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!

Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s. Makes me also wonder how many could be druggable targets.

Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.

Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbM–cortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social

The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes. These findings link vascular risk and Alzheimer’s mechanisms.

Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response www.mdpi.com/1422-0067/26...

Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinson’s disease treatment! cell.com/cell-stem-ce...

Great study dissecting molecular hallmarks of neuronal resilience in Alzheimer’s disease highlighting natural protective mechanisms that could help preserve cognition. x.com/rust_ruslan/...

Can stem cells help to regain brain function after stroke? Our new study in NatureComms @natureportfolio.nature.com shows that they can and dissect the key mechanisms driving recovery. t.co/KRfAHfkNIH

Effects of psilocybin and related compounds on neuroprotection in human stroke www.researchhub.com/fund/4261/ef...

Delayed Transplantation (7 vs 1 dpi) of #NeuralStemCell Improves Initial Graft Survival after #Stroke ⏫graft axon extension along #CorpusCallosum to contralateral hemisphere @ctackenberg.bsky.social @rrust.bsky.social #AdvSci 2025 advanced.onlinelibrary.wiley.com/doi/10.1002/...

"Authentic" #hiPSC-derived #Pericyte 😎 Sharing highly similar proteome/phosphoproteome to primary👤🧠cortical pericyte Contractile ⏫ #BloodBrainBarrier & Neuroprotective (Pdgfrb F7/F7🐭) Clear Aβ Tau (🧠slices 5xFAD🐭 APOE4 P3001S🐭) @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

#hiPSC derived #Pericyte 👉>80% Home to & >50% Arborize on Capillaries in live🧠slice of PdgfrbF7/F7🐭 in situ PDGFBB-PDGFRβ PLA assay😍 👉⏫Amyloidβ clearance on 10-m/o 5xFAD 🐭🧠slice Are these phagocytic pericytes still vessel-bound?😁 @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...

#Medsky🧪 #Neurosky Much of stroke research focuses on acute injury - but what changes in the brain one month after stroke? By @rrust.bsky.social et l link.springer.com/article/10.1... www.researchhub.com/paper/938498...

Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma. Wonder if these NSCs exist in humans & can show similar therapeutic potential www.nature.com/articles/s41...

New preprint🚨 We generated human brain pericytes from pluripotent stem cells. They show strong molecular & functional similarities to primary human brain pericytes Transplanted into pericyte-deficient mice, they formed hybrid human-mouse microvessels🐭 biorxiv.org/content/10.1...

Dynamic structural connectivity changes in cortical and cortico-striatal strokes in mice https://www.biorxiv.org/content/10.1101/2025.03.27.644898v1

A new review from our lab exploring how the blood-brain barrier (BBB) can be used as a treatment target for neurodegenerative disorders tandfonline.com/doi/10.1080/... TL;DR → Here are a few key highlights 👇

Here's a very cool paper from @biorxiv-biophys.bsky.social I shared on ResearchHub this week. The authors designed a three-legged motor protein that can walk down DNA in either direction. www.researchhub.com/paper/930685... 🧪 @researchhubf.bsky.social

Optimize the time window for cell therapy for #Stroke Photothrombosis Rag2-/-🐭 hiPSC-#NeuralProgenitorCell intracerebral injection 7 days (vs 1 d) post injury➡️ ⏫NPC proliferation ~20-fold⏫survival by 7-wk dpi👍 @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

Do our genes sabotage our bodies? @haoyin.bsky.social reviewed a bioRxiv paper that suggests a special gene helps melanoma (a type of skin cancer) grow and evade the immune system. 🧵1/7

Nice roundup on CRISPR genome editing @economist.com www.economist.com/leaders/2025...

#Medsky🧪 #IDsky #Immunosky #publichealth the study showed that rising self-antigen levels during infection give self-reactive #Tcells an opportunity for enhanced TCR signalling. Regulatory T cells of matched specificity counteract this that’s preventing autoimmunity. www.science.org/doi/10.1126/...

Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...

New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...

#Medsky🧪 #IDsky #immunosky #neurosky This study shows that delayed intracerebral transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent cells (iPSCs) at 7 days post #stroke significantly enhances graft proliferation and survival…

Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️ Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold. www.biorxiv.org/content/10.1...

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Glomerular Neovascularization #DiabeticKidneyDisease #CaseReport #SpatialTranscriptomics #Visium @10xGenomics 50-μm section multiplex IF TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule #KPMProject #CJASN 2024 journals.lww.com/cjasn/abstra...

Thank you @castltrastondrs.bsky.social for highlighting our work!

Cool work!

Zenodo vs Open Science Framework

New study led by @cathnaledi.bsky.social showing that physical exercise improves #cerebrovascular function in mice with genetic risk for Alzheimer’s disease.

DeepSeek R1 is making headlines in the news and is being compared to OpenAI's o1. However, many have not read the preprint. We invite you to evaluate the DeepSeek R1 preprint at @researchhubf.bsky.social , and reward high-quality contributions with 150$ (in RSC). researchhub.com/paper/916140...

papers.ssrn.com/sol3/papers.... #cerebrovascular

Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.

Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels https://www.biorxiv.org/content/10.1101/2025.01.08.631889v1

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations https://www.biorxiv.org/content/10.1101/2025.01.08.631962v1

Very cool work!

A really 🔥 topic ! "The pathobiology of neurovascular aging" www.cell.com/neuron/fullt... #cerebrovascular

Excited to join the editorial team at @researchhubf.bsky.social to improve high-quality + open research. I’ll be sharing new preprints and my thoughts on them regularly. I truely believe that the publishing landscape needs to change and would encourage you to check out our mission:

This is the most comprehensive review on Alzheimer’s and inflammation I’ve read in a long time. Highly recommended for anyone interested in learning about AD research or future therapeutic possibilities in AD 🧠🧪 www.nature.com/articles/s41...