Excited to share our pre-print on the curation of a new bioactivity dataset for metabolic transformations. 🧪🧑‍💻 We were surprised to find that roughly a quarter of our drug-metabolite-target combinations contain metabolites with retained or increased bioactivity relative to the parent drugs! #chemsky

FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life www.nature.com/articles/s42...

New paper alert: Paralog interference contributes to the preservation of genetic redundancy www.cell.com/current-biol...

A very good list of Computational Biology Conferences and their deadlines! databio.org/conferences/

Now out in @natcomms.nature.com : versions 2.0 of both BiG-SCAPE and BiG-SLiCE! With significant speed and accuracy increases, as well as new interactive functionalities. Read the full paper here #openaccess: www.nature.com/articles/s41...

Sounds like a great opportunity for a professor position in computational biology in the Netherlands careers.universiteitleiden.nl/job/Assistan...

TF-MoDISco: Transcription Factor Motif Discovery from Importance Scores (2017) arxiv.org/abs/1811.00416 YouTube: youtube.com/watch?v=fXPGVJg956E GitHub: github.com/kundajelab/t...

Can we simulate realistic evolutionary trajectories and “replay the tape of life”? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n doi.org/10.64898/202...

🧬We are launching STRiVE, a @eseb.bsky.social Special Topic Network on the evolutionary role of structural genomic variation. 🗓️Std: 29/04: Online seminar w/ L. Rieseberg 8-10/07: Kick-off in Porto Join us: structuralvariantsstn.github.io #Evolution #Genomics #StructuralVariants #Biology #PopGen

My university (Chalmers University of Technology in 🇸🇪) is recruiting an assistant professor in data-driven cell & molecular biology, funded by the DDLS program @scilifelab.se #chemsky #facultychemjobs The position comes with a nice start-up package www.chalmers.se/en/about-cha...

Come join us again in a next round of this massive online open science community effort! 💪 Sign up using the link in the thread. It’s great fun, and really helps the scientific community. What more can you ask? 🙂

kache-hash: A dynamic, concurrent, and cache-efficient hash table for streaming k-mer operations https://www.biorxiv.org/content/10.64898/2026.02.13.705625v1

Our new review on genome annotation just appeared in @naturerevgenet.bsky.social, with a particular focus on the human genome, with Hayden Ji and Mihaela Pertea: rdcu.be/e4mI1

I’ve written a post about my recent experiences (successes) with AI coding models; the experiences that caused me to re-evaluate my initial judgements, the surprise I had at what can be accomplished, & some fears I have about these tools. Discussion welcome! combine-lab.github.io/blog/2026/02...

Come to Ascona and attend talks from Maria Brbic Charlotte Bunne Faisal Mahmood Dana Pe’er Barbara Engelhardt Caroline Uhler Julien Gagneur Marinka Zitnik Julie Josse (INRIA) Basile Wicky Fabian Fröhlich with a beautiful view of the lake in the Swiss Alps! ascona2026.sciencesconf.org

If you are a scientist, working on biology, wondering where to submit your manuscript given the current issues with the academic publishing system, check out wheretopublish.github.io! We did this thinking change is possible. Let’s make it happen!

De-novo promoters emerge more readily from random DNA than from genomic DNA www.biorxiv.org/content/10.1...

I'm looking for a Swiss department to host me for an SNSF Starting Grant. I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com If your department might be a match, let’s chat!

Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)

Please spread the word: We invite applications to a two-week Computational Biology workshop in Singapore, June 14-27. This NSF-funded workshop brings together 16-20 US grad students with international peers. Apply by March 21: compbioasia.net 🧵 Details below:

Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job

#biodiversity #bioinformatics Summer School announcement ... 21-26 June in Siegen, Germany co-organised by @sib.swiss & @denbi.bsky.social www.sib.swiss/training/cou... 🟢 eDNA & ecosystems 🟣 pangenome diversity 🔵 population genetics 🟡 comparative genomics

🚨🧪 Announcing our #ICLR2026 Workshop, Generative AI in Genomics (Gen2): Barriers and Frontiers! @iclr-conf.bsky.social 📣Call for: Full workshop papers (5-8 pages) and Tiny papers (2-4 pages) 📅Submission deadline: 7 February 2026 AoE 🌐Learn more: genai-in-genomics.github.io (1/7)

Join us for our next Kipoi Seminar with Jun Cheng, DeepMind 👉 AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model 📅 Wed Feb 4, 5:30pm CET 🧬 kipoi.org/seminar 🦋 @kipoizoo.bsky.social

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

GLADE takes a fully phylogenetic approach. It uses orthogroups, gene trees, and the species tree to infer gains, losses, and duplications, and to map each event onto the phylogeny. (4/10)

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...

We devised a benchmark method to quantify the impact of homolog enrichment on phylogenetic inference, decomposing the effects on MSA quality, tree inference quality, and rooting. We show homolog enrichment improves tree inference, while effects on alignments remain marginal. 🧵2/n

"The repertoire of short tandem repeats across the tree of life" by Nikol Chantzi and Ilias Georgakopoulos-Soares doi.org/10.1186/s130...

Interesting in the CSHL Biology of Genomes conference, but need support attending? The @jxtxfoundation.bsky.social will provide support to 3 students in genomics and data sciences to attend. The deadline is Jan 31, 2026 and just takes a short bio and abstract: jxtxfoundation.org/news/2025-12...

The impact of tokenizer selection in genomic language models doi.org/10.1093/bioi...

Mapping the genomes of other mammals gives us a deeper understanding of the biology behind diseases that also occur in humans. Kerstin Lindblad-Toh aims to trace the genetics behind diseases such as obsessive-compulsive disorder #OCD #ALS and #cancer. #research #genomics @uu.se tinyurl.com/4nadrydb

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

The next step in a great scientific adventure led by @mbrasovives.bsky.social on amphioxus evolution: population genomics of a species with 3% heterozygosity! Read the thread and the preprint 😁

Super-pangenome analyses across 35 accessions of 23 Avena species highlight their complex evolutionary history and extensive genomic diversity doi.org/10.1038/s415... Common oat=Avena sativa

In Nature Genetics: As part of the BioDIGS project, mikeschatz.bsky.social and colleagues are broadening pathways into genetics and data science, engaging students from diverse institutions nationwide to study links between soil biodiversity and health. engineering.jhu.edu/news/science...

I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt: employment.utah.edu/salt-lake-ci...

Targeted ortholog search in unannotated genome assemblies with fDOG-Assembly doi.org/10.1101/2025...

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

Evolutionary transcriptomics unveils rapid changes of gene expression patterns in flowering plants doi.org/10.1016/j.ce...

🚨My department is hiring a full-time Assistant Teaching Professor to teach undergrad Genetics & Genomics, upper-level Genomics, and an inquiry-based Computational Genomics course where students can do authentic research. 🧬💻 I’m on the search committee. DM me if you’re interested. Please share! 🙏

Blogpost: I took an oral probiotic for a month and did microbiome sequencing at @Plasmidsaurus. blog.booleanbiotech.com/oral-microbi...

The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31 probgen2026.github.io

ntSynt: multi-genome synteny detection using minimizer graph mappings doi.org/10.1186/s129...

From @jchowning.bsky.social & colleagues in @plos.org #Computational #Biology | Ten simple rules for running a virtual program to introduce computational biology at the high school level | #Education #Bioinformatics #PLOSCBTSR #OpenScience 🧬 🖥️ 🧪 🔓 ⬇️ journals.plos.org/ploscompbiol...

The #European Meeting for PhD students in #Evolutionary #Biology (EMPSEB) is a student-led annual conference that brings together PhD researchers from around the world. Germany, 8th to 12th of June, 2026 empsebconf.github.io

We have detected that you are currently in a State where we do not offer the following rights to residents: - Right to Know - Right to Delete [the account] Currently, we only offer these rights to residents of Virginia, Texas, New Jersey, Delaware, Nebraska, Iowa and California !!!

Thrilled to share our new review online with @scottvedwards.bsky.social in @Trends Ecol & Evo! “pangenomics is rapidly transforming our ability to dissect the genetic basis of ecological and evolutionary change in natural systems.”

The 2026 JASPAR NAR paper provides a very good overview of literature of Deep Learning-based transcription factor analysis. Manual curation of >11k profiles across different species is amazing! Paper: doi.org/10.1093/nar/... Platform: jaspar.elixir.no