We’re hiring for OrthoFinder! Great role for someone who enjoys scientific software development: Python, data analysis, workflows, Git, scalability, and making tools nicer to use. Comparative genomics or open-source bioinformatics experience would be a lovely bonus. my.corehr.com/pls/uoxrecru...

Brutal and sad. The article mentions multiple scientists, but I happen to know Sean. Sean is true role model, as a scholar, engineer communicator & mentor. He has poured time into serving NIH. If the NIH / White House is kicking Sean to the curb, we're truly done for www.npr.org/2026/05/21/n...

A novel method for across-chromosome phasing without relative data doi.org/10.1093/bioi... Bioinformatics, 2026

Looking to contribute to the future of #ScientificResearch 🧪 in 🇨🇭? The SNSF Research Council is recruiting 21 new members for its six committees. The mandates will start in April and October 2027. Interested? 🗓️ Apply by 14 June 2026. www.snf.ch/en/pk2qftWyV...

Revamped the teaching materials site. Light/dark mode switch at the top. More consistent, compact presentation of all the materials. + Icons and such! www.langmead-lab.org/teaching.html

Sizzling hot off the presses!!!

Passionate about comparative genomics? Join us in Lausanne for the Quest for Orthologs meeting, just before ECCB. Submit your abstract by June 1st qfo2026.unil.ch Travel fellowships available!

This is a fantastic mentoring opportunity!

The human genome's most variable and clinically important regions (centromeres, telomeres, and acrocentric short arms) have been hardest to study at scale. Thrilled to share KaryoScope, our new preprint that brings them within reach. 🧵 www.biorxiv.org/content/10.6...

Population-level structural variant characterization using pangenome graphs www.nature.com/articles/s41... Swave introduces 'projection waves` to summarize the dotplot images, capturing mapping patterns in pangenomes. A recurrent neural networks distinguishes true SV from background noise/repeats.

I've seen lots of AI rewrites in bioinformatics lately, and I’m concerned because LLMs can be confidently wrong. What do the best tool builders do to make sure their rewrites are correct? How can we tell if a rewrite is flawed? I interviewed 5 scientists to find out: youtu.be/0o2XnEBDxrI

MemPang26 conference (today) Schedule: pangenome.github.io/MemPanG26/#_... Free Livestream: tennesseehipaa.zoom.us/j/86514448732

Now published in NSMB! Paper: doi.org/10.1038/s415... Full PDF: rdcu.be/fhBtI Overview of additions since the preprint👇 (1/5)

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

The ERGA BioGenome Seminar Series is back! We return with Jérôme Goudet and Isabela do O for a seminar on the impact of population structure in identifying local adaptation. How do we know when population differences reflect adaptation, and when they are shaped by demography and structure?

🔍 New paper in Bioinformatics Advances: "Kaminari: A frugal colored index for approximate k-mer queries"  Read it here: https://doi.org/10.1093/bioadv/vbag120 Authors include: @yhhshb.bsky.social, @yoann.bsky.social, @robp.bsky.social, @pierrepeterlongo.bsky.social, @jermp.bsky.social

Excited to announce we’ve constructed a complete, haplotype-resolved assembly of a human pancreatic cancer genome. By comparing tumor cell line and normal tissue assemblies directly, we developed phased somatic benchmarks. Thanks to many in GIAB! www.biorxiv.org/content/10.6...

ALF—A Simulation Framework for Genome Evolution academic.oup.com/mbe/article/... Molecular Biology and Evolution, 2012 Online platform: alfsim.com

Hash functions in nucleotide sequence analysis doi.org/10.1101/gr.2... Genome Research, 2026

Celebrate the last day of finals by joining us for the last CS seminar of the semester @sergek.bsky.social! Learn more here: www.cs.jhu.edu/event/cs-sem...

Applications due tomorrow!

Two days left to apply for PhD positions in genomics and machine learning in the CGR lab (Data Science and AI Division at Chalmers, Sweden). We also have postdoc openings. Please get in touch! CGRLab.github.io/research/

Ten common mistakes that could ruin your enrichment analysis journals.plos.org/ploscompbiol...

3. If the problem is interesting and important, most reviewers (myself included!) will wonder why someone has not tackled it already. Therefore there has to (usually) be something that has changed from 2 or 3 years ago until now that makes the approach you are suggesting feasible

Grant writing tips from a grumpy reviewer ploughing through grants. 1. Often your reviewers are going to come from a broad range disciplines adjacent but *not actually in* in your field. Help us get orientated in the summary with an analogy/sketch and go back to analogy / sketch throughout.

GPC: Deep generative model of genetic variation data improves imputation accuracy in private populations openreview.net/forum?id=B0H... ICLR 2026 Workshop Gen2

Should we measure trait evolution in unit of time or in unit of substitutions? Our new paper in @evolletters.bsky.social looks at this from a theoretical perspective. #Evolution #Phylogenetics DOI: doi.org/10.1093/evle... 🧵 thread below 🧵

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

Panmap: Scalable phylogeny-guided alignment, genotyping, and placement on pangenomes www.biorxiv.org/content/10.6...

🧬 Join the VESS Organizing Committee! We are looking for early-career scientists to help shape our global, community-driven seminar program. 📅 Deadline to apply: April 30, 2026 ℹ️ Learn more and apply👇 forms.gle/vdLh3mu9Fuid... #VESS #VariantEffects #Seminar #Genomics #EarlyCareer

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That’s a gem! I use these for my K99 and faculty job applications. Thanks to all contributors!

This is from 7 years ago (merenlab.org/2019/02/24/f...). We are talking about the same things today. We will be talking about the same things 7 years from now. There is no one to blame for this apart from ourselves. I find it very depressing.

Appeals: what, why, when, how www.nature.com/articles/s41... "By an appeal, we mean the formal process of reconsidering a manuscript that has been previously rejected by a journal, either before or after peer review."

Genomic LLMs in practice 🧬🤖 Train and apply transformer models to DNA sequences. Tutorial organized by: Megha Hegde, Shashank Ravichandran, Jean-Christophe Nebel, Ragothaman Yennamalli and Farzana Rahman Register here: 👉 eccb2026.org/registration... #ECCB2026 #Genomics

Interested in predicting the dynamics of antibiotic resistance? Come work with us! We're looking for two postdocs to develop predictive models of resistance. We're interested in a range of approaches (mathematical & statistical modelling, causal inference, machine learning). tinyurl.com/6c4y3jke

(1/2) Interested in plant evolution? We are opening two PhD positions in my lab at QGG - Aarhus University, where you will combine comparative genomics and machine learning to better understand and improve crop traits. #PlantSciJobs #evolution #genomics

From DNA to discovery: what are the steps of HiFi sequencing? 🧬 This blog breaks down the 5-step PacBio workflow, covering everything from Nanobind sample prep to real-time data analysis on the Revio and Vega systems. See how it all comes together: bit.ly/4vDRhGW #PacBio #HiFisequencing #Genomics

blog post - State of the lab 13, part of yearly series, tracking our lab's progress in academia. This year I am mostly reflecting back on our slow adoption of DL methods, FOMO of new technologies and anxiety about the use of AI for research www.evocellnet.com/2026/04/stat...

Nature Language Model: Deciphering the Language of Nature for Scientific Discovery arxiv.org/abs/2502.07527 Design a heme-binding protein sequence. ⟨protein⟩MSAAEGAVVFSEEKEALVLK· · · ⟨/protein⟩ Generate a molecule with four hydrogen bond donors. ⟨mol⟩C(C[C@@H](C(=O)O)N)CN=C(N)N⟨/mol⟩

Join us for the Celebrating Women in Data Science and AI Symposium on April 14 from 10 a.m. to 4 p.m. Register now to hear from leading women in data science and AI through dynamic talks, panel discussions, and a poster session. ai.jhu.edu/event/celebr...

To simplify, we began hosting a web page to index and simplify tracking RECOMB papers and their preprints and journal versions at recomb.org/proceedings/ This page serves as a central directory for all RECOMB publications.

📢 MicroRNA folks : We are looking for RNA-seq data comparing transcriptomes of mutants in which one particular miRNA locus of the genome was inactivated (by e.g. a tDNA insertion or by CRISPR) with their wt controls. Any hint ?

Please, don't write cover letters with AI when applying to jobs. Selection committees see so many of them in a short time window and artificial constructions become too evident. I prefer an honest cover letter with grammar errors, made with effort, rather than a fake one.

In July, we will teach the 3rd biodiversity genomics course in Latin America, this time in Bogotá, following the COLEVOL meeting. We invite applications from students, postdocs and PIs from Latin America interested in learning how to analyse genomic data. biodiversitygenomicslatam.weebly.com

A run-length-compressed skiplist data structure for dynamic GBWTs supports time and space efficient pangenome operations over syncmers doi.org/10.64898/202...

Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj

I am looking for short papers using phylogenetic trees to test alternative hypotheses regarding evolution that can easily be grasped by undergraduate students in biochemistry. Please RT and share your ideas.

Congratulations to 3rd-year undergrad Steven Tan (first author!!), @benlangmead.bsky.social, @mohsenzakeri.bsky.social, & @sinamajidian.bsky.social on their Best Paper Award at @acm-bcb.bsky.social 2025! 🏆

How much protein diversity can Life on Earth actually generate? With DIAMOND DeepClust, we show how billions of proteins across the tree of life can be clustered at low-identity for downstream analytics tasks. 📚Paper: www.nature.com/articles/s41... 💻Code: github.com/bbuchfink/di...