Whole brain dynamics in the ~10s regime shows synchronized propagation of topographically organized rotating waves, driving behavior, calcium fluxes, band-limited power, metabolism, blood flow, etc. All can be predicted from time-lagged embedding of pupil size alone! www.nature.com/articles/s41...

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

LinkedIn just notified about my 4th year annyversary working at the @bsc-cns.bsky.social, time flies!!! It's been a great chapter so far in my scientific journey!! A lot of projects on the list! #ILoveScience

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳 📖 Preprint: www.biorxiv.org/content/10.1... 🔍 Explorer: explore.omnipathdb.org OmniPath integrates 160+ resources for multi-omics analysis & modeling. 🧶⬇️

New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴 doi.org/10.48550/arX...

Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...

It was lovely to speak at the CATH 30 symposium, celebrating 30 years of the @cathgene3d.bsky.social protein structure classification database. I was presenting recent work on our new generative protein-family language model: preprint coming soon.

Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail nature.com/articles/s41467-025-63463-6

Dear Colleagues. We are in need of a molecular dynamics trajectory of a "folding upon binding event" where a protein with an IDR folds into its partner. Do you know of any published and available trajectory that we could use?? Thanksss a lot!

Spacedust: a tool for de novo identification of conserved gene clusters from metagenomic data. @ruoshiz.bsky.social @milot.bsky.social www.nature.com/articles/s41...

Rob Finn on MGnify, everything bacteria and functions in different environments

Now Maria Martín from UniProt is telling us how AI-based tools are shaping the future of one of the key resources for protein sequences and function.

From structures to sequences, now Alex Bateman and the quest to annotate and classify all proteins!

Starting our afternoon session with a talk by Sameer Velankar, of PDBe and AFDB fame among other endeavours!

And now @gonzaparra.bsky.social on his first talk on protein frustration as a PI! Well done!

David Jones, on novel folds in AFDB and CATH’s founding being celebrated at a now-closed Pizza place in Euston Station

From CATH to Computational Enzymology, Dame Janet Thornton on the birth of CATH and beyond!

First Keynote by Burkhard Rost, on the impact of protein language models on the field of structural biology

Kickstarting our symposium “Protein Annotations in the age of AI” at UCL!

Stephen Jay Gould was born OTD in 1941. “Organisms are not billiard balls, propelled by simple and measurable external forces to predictable new positions on life's pool table.... Organisms have a history that constrains their future in myriad, subtle ways.” 🦫🦋🐋🌱🧠🗃️🧪#HistSTM #PhilSci #EvoBio

In the face of climate change, the race to understand life on Earth is on. @ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035. At EMBL-EBI, we annotate these genomes, making them openly available for the global research community. www.ebi.ac.uk/about/news/a...

🚨 New in PNAS! 🧬 64% of disease co-occurrences can be explained by transcriptomic similarities. Comorbidities aren’t random—they have a molecular basis. Here’s how we found it 👇 (1/n) 🔗 doi.org/10.1073/pnas.2421060122 @alfonsovalencia.bsky.social

Repeated heatwaves can age you as much as smoking or drinking "Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing." www.nature.com/articles/s41...

CATH turns 30 years old 🥳 They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families" Unbelievable selection of speakers! So if you are around London, you can register to attend: tinyurl.com/2pnk8hj5

Congratulations @judewells.bsky.social!

FANTASIA's paper is finally out! Check it out if you're interested in alternative methods to homology for functional annotation in nonmodel organisms 🦐🐙🪱🧬🐝🪲 @gemmaeling.bsky.social @amrojasm.bsky.social @ibe-barcelona.bsky.social @cabd-upo-csic.bsky.social @csic.es www.nature.com/articles/s42...

If you'd like to showcase your research with a poster, details are included in the registration page. We hope to see you there!

We have a stellar lineup of speakers! Christine Orengo Burkhard Rost Janet Thornton David Jones Gonzalo Parra @gonzaparra.bsky.social Sameer Velankar Alex Bateman Maria Martin Rob Finn Gerardo Tauriello Alexey Murzin

There will be talks from world leaders in structural bioinfomatics on various themes including pioneering protein language models and key international resources including: PDBe, InterPro, UniProt, MGnify, SWISS-MODEL, FrustraEvo and CATH.

CATH turns 30 years old this year! We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses. www.eventbrite.co.uk/e/protein-an...

Our latest preprint is out on bioRxiv! A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins! We reveal biome-specific groups & over 11k novel domain combinations.

Todo es ciclico, lamentablemente... Hay anticuerpos culturales que tienen a diluirse y permiten que las viejas ideas vuelvan a ejecturarse... para bien o para mal.. Esperemos pronto volvamos a politicas progresistas e inclusivas.. Por el momento queda resistir.

Hey everybody! @drjuliawester.bsky.social and I have a new paper! We surveyed over 800 scientists, science communicators, and science educators who use social media. Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑 doi.org/10.1093/icb/...

🧬 Today starts the most relevant event in evolutionary biology: the European Society for Evolutionary Biology (ESEB) Congress (@eseb2025.bsky.social @eseb.bsky.social). 🔝 #IRBBarcelona's group leader @tonigabaldon.bsky.social is the chair of this major event that will gather +1900 participants. 👇

❗New Preprint w/ C Bueno (‪@cabb99.bsky.social‬), IE Sánchez (@nachoquique.bsky.social‬), PG Wolynes & DU Ferreiro (@diegulise.bsky.social‬) We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins arxiv.org/abs/2508.08109

Can't believe IUCr is only a year away! How many structures will be in the PDB in August 2026?

Finally online: my 1st current opinion article & my 1st article with only 2 authors, small dreams I had since my PhD student years! I hope you enjoy reading it! "Frustration, dynamics, and catalysis" together with my mentor Diego Ferreiro ⭐️ link: t.co/q0K2g61F13

Many Europeans had the dark skin and eyes of their African ancestors well into the Bronze and Iron ages, according to estimates of genotype likelihoods for 348 ancient genomes from Eurasia. In PNAS: www.pnas.org/doi/10.1073/...

MMseqs2 v18 is out - SIMD FW/BW alignment (preprint soon!) - Sub. Mat. λ calculator by Eric Dawson - Faster ARM SW by Alexander Nesterovskiy - MSA-Pairformer’s proximity-based pairing for multimer prediction (www.biorxiv.org/content/10.1...; avail. in ColabFold API) 💾 github.com/soedinglab/M... & 🐍

Finally online: my 1st current opinion article & my 1st article with only 2 authors, small dreams I had since my PhD student years! I hope you enjoy reading it! "Frustration, dynamics, and catalysis" together with my mentor Diego Ferreiro ⭐️ link: t.co/q0K2g61F13

One month remaining to register for our conference! Have a look at the outstanding speakers and programme, and use the link to join the 2nd edition of the Computational Structural Biology Conference in Heidelberg!

Every assessment or metric looking at AI in drug development suffers from the Who's Line is it Anyway law where everything is made up and the points don't matter. Here, "AI readiness", a composite of several proxy metrics measuring spending, rather than outcomes www.cbinsights.com/research/ai-...

Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome www.genengnews.com/t...

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

Happy that our proposal "MEGA-scale Frustration Analysis of the Protein Universe: Evolution, Dynamics, and SNV Impact (MEGAFrustratEDS)" got selected to be funded by @ageinves.bsky.social! This is the 1st research grant to fund my team at @bsc-cns.bsky.social as a Ramon y Cajal Researcher! Thankful⭐️

Great to speak in excellent #3DSIG meeting at #ISMBECCB2025 on physics-based simulations in the Age of AlphaFold

There are @iscb.bsky.social President elections at ISMB this year. All candidates are great but I wanna call votes for Francisco de la Vega who could become the first President coming from Latin America!! Remember to vote if you're an ISCB member! ⭐️

Molecular cat tweezers? 😺

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...