GPU-accelerated MMseqs2 offers tremendous speedup for homology retrieval, protein structure prediction with ColabFold, and protein structure search with Foldseek. @martinsteinegger.bsky.social @milot.bsky.social @machine.learning.bio www.nature.com/articles/s41...

And now @gonzaparra.bsky.social on his first talk on protein frustration as a PI! Well done!

Great #networkmedicine work by @alfonsovalencia.bsky.social's team on deriving comorbidity networks from RNA-seq data to study complex disease relationships. Thy show that molecular mechanisms are behind many of the known comorbidities (often via immune response). doi.org/10.1073/pnas...

💻🧬'Los vínculos secretos que existen entre enfermedades. El estudio del BSC representa el mayor esfuerzo hasta la fecha para explicar científicamente las asociaciones clínicas entre enfermedades' 🗞En @innovaspain.bsky.social ➡ www.bsc.es/4kD @alfonsovalencia.bsky.social @beatrizurda.bsky.social

Excited to see our PNAS paper highlighted on Kudos, with an accessible take on the findings. Disease links are not random—they can be predicted from the expression of our genes. www.growkudos.com/publications... @pnas.org @alfonsovalencia.bsky.social 📄 doi.org/10.1073/pnas...

7/ Huge thanks to @alfonsovalencia.bsky.social for his continued support and excitement in this wild, fascinating project, and to all co-authors (Jon,Alba) & funding agencies. To the @bsc-cns.bsky.social for indispensable comput. resources, and to all patients & teams who made omic data available.

She explains part of the fight over 2 years with an absurd referee (can happen) and an incompetent profesional editor unable to understand even basic statistics - or worse unable to take a decision by him/her self. But never mind: Beatriz won and the paper is now published in a better journal.

1/ Everything that could go wrong in paper publishing… did. A story of patience, absurdity, and persistence 🌀 <1min From Alfonso Valencia’s lab and a very stubborn PhD student (me).

Very happy to get it out. For scientific & personal reasons this one is special. Beatriz has done more work and endured the most difficult - and absurd - publications battles I can remember. Thanks to PNAS for being "normal" and congratulations to Beatriz. (Beatriz: next one will be easier!)

🚨 New in PNAS! 🧬 64% of disease co-occurrences can be explained by transcriptomic similarities. Comorbidities aren’t random—they have a molecular basis. Here’s how we found it 👇 (1/n) 🔗 doi.org/10.1073/pnas.2421060122 @alfonsovalencia.bsky.social

elpais.com/espana/2025-... No estaría mal llegar también en ciencia, no? (sector empresarial,,, financiando el 0,72% del gasto en I+D sobre PIB y ejecutando el 0,84%. … sector público ha financiado el 0,63% del gasto en I+D sobre PIB y ha ejecutado el 0,65%) informe del ministerio - julio 2025

Quoting Miguel Ponce de Leon main author of the paper: “our work provides a novel approach to study the effect of interregional mobility on epidemic spread & to uncover spatio-temporal patterns of mobility-driven transmission, with insights to inform the timing and regional targeting of NPI”

📢 New Publication Alert! The study uses an advanced method called Transfer Entropy on massive phone mobility datasets to map the influence of travel on COVID-19 spread across Spain Find the full open-access paper here: crexdata.eu/publication/... @alfonsovalencia.bsky.social @bsc-cns.bsky.social

I wonder why this book - and not only this one- is more expensive in Spanish than in Italian in the Apple Store?

¿Cuánto cuesta en términos energéticos cada pregunta que le hacemos a la IA? Google ha presentado un dato inicial sobre su propio servicio: “Es el equivalente a la electricidad necesaria para veer la televisión nueve segundos” social.elpais.com/8lzid15

The grave risks for science as the whole of leaving fundamental scientific infrastructure in the hands of for-profit capitalist company. Essential scholarly services should be internationally curated by value-based societies/orders/colleges. 🧪

La Junta de Castilla y León descartó ante la Unesco que el cambio climático supusiera un peligro para Las Médulas

I’m truly honored to be elected Vice President of ISCB, and heartfelt thank all ISCB members for your trust and support. I’m excited to work alongside Bonnie and the rest of the EC to keep building a strong, sustainable, inclusive, and forward-looking community for computational biologists worldwide

This week in Geneve the ocean health on the spot: New extra round of UN talks to reach international deal on plastic pollution. Best wishes of success!! We need it!

Un nuevo informe de #ISGlobal revisa la evidencia científica y plantea recomendaciones para un #TratadoGlobal sobre #plásticos más ambicioso y centrado en la salud. 🟠 https://f.mtr.cool/gwepejkair #SaludPlanetaria

El día de la humillación www.lavanguardia.com/opinion/2025... “Se puede” recobrar la autonomia estratégica Europea por Andreu Mas-Colell

This is depressing. I have had conversations with @alfonsovalencia.bsky.social on this for > 25 yr. Computation is not just a tool to organize & analyze data, but a genuine source of new knowledge—something that old-school molecular biologists fail to grasp ☹️

Pretty sure this is not only a Spanish problem. I've been told I shouldn't do those expensive computations but use NMR instead. Or, when partnering with cristallographers, that I wasn't an expert in crystallography. And of course anything structural biology that doesn't include X-ray/NMR/cryo-EM...

We are being crushed between people that tell us to do experiments and the ones that tell us to use AI for the models...

I was told by them "La hipótesis es sólida y el enfoque original. Sin embargo, no se explica con claridad cómo se validarán experimentalmente las simulaciones, lo que debilita en parte la consistencia del planteamiento." There was no validation intended... One more thing to fix in Spanish science!

It is widespread. Proposals solving biological problems w/computational methods are rejected because they are seen as less valuable than those generating new data, and told to apply to computer science calls, where they would be reviewed by panels of people doing cryptography and quantum computing.

The research project of one of my collaborators was rejected by the Spanish agency because the COMPUTATIONAL project is NOT experimental ("El proyecto se queda en el ámbito computacional pero sin una validación biológica, aunque sea sencilla se queda un poco corta la validez.") Really? in 2025?

Wonderful launch of our new ERA Chair project with a kind, insightful, and stellar group of scientists. Thank you Claudi Bockting, Søren Brunak, Ana Teresa Freitas, John Krakauer, Francisca Leite, Pedro Lima, Jörg Menche, Isabel Rocha, @alfonsovalencia.bsky.social Susana Vinga, and many others!

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

At the end of the year, Luis Serrano will be stepping down as @crg.eu  Director, after 14 years in the role.  The CRG's Board of Trustees has appointed Prof Monica Bettencourt-Dias as his successor.  Congratulations❗ ℹ️https://tuit.cat/ufMdp

🟢 The emission of certain particles, such as iron, when deposited in the ocean, acts as a fertilizer and stimulates the growth of phytoplankton, which absorbs CO2 from the atmosphere. This increase could have a significant impact on the North Atlantic

🌊🔥 New study on the link between wildfires and marine ecosystems 🌍 The increase in wildfires due to #climatechange could alter the ocean’s absorption of CO2, according to a study by BSC published in @NatureClimate ➡ www.bsc.es/ZtF

🧬 Emilio Muñoz rememora su vínculo de más de 60 años con Federico Mayor Zaragoza. Un relato personal que encontrarás en nuestro último nº de @SEBBM_Revista  🔗 https://f.mtr.cool/etaucvdqtc

Study showing that the global “plastosphere” contains more than 16,000 chemicals, much more than previously expected. Importantly, at least 4,200 plastic chemicals are of concern because of the hazards they pose to health and the environment. #empa www.empa.ch/web/s604/bed...

🧵 1/9 I want to share some (inconclusive) thoughts about the generalization capabilities of protein language models under this main question: ¿what does it mean IN distribution generalization and what does it mean OUT of distribution generalization in (protein) biology?

🔴 El Papa llama a la “conversión de quienes aún niegan la urgencia” del calentamiento global elpais.com/clima-y-medio-a...

Very nice preprint on the importance of #FAIR data resources in the life sciences, for AI and generally for science, by a great @sib.swiss team led by @dessimoz.bsky.social. With @bgee.org inside ;) zenodo.org/records/1572...

📣 ELIXIR has awarded €124,000 in infrastructure service funding to support the Beacon network. The funding will support 💪 operational activities at ELIXIR Spain, ELIXIR Switzerland & ELIXIR Finland. @ga4gh.org Read the news: https://loom.ly/HZeATDA

This is great! Thank you. Can the SIB help to keep the CASP challenge running?

Pedro Simas opening words for the presentation of the CBeRa chair (@cberaproject.eu) lead by @lmrocha.bsky.social Happy to see this complex systems initiative flying

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

🚨 Last day for early bird registration to the Barcelona Blood-Brain Barrier Conference #B4Conference2025! We're kicking things off by introducing our amazing Chairs! Don’t miss out 👉 premc.org/blood-brain-...

Quines són les professions de la Biologia⁉️ Els #Biòlegs i #Biòlogues #CuidemLaVida, per això ens trobareu en la #Recerca i #desenvolupament i en tots els estudis d'organismes vius  1️⃣   #microbiologia #biomedicina #biologiaanimal  🔗 https://cbiolegs.cat/sortides-professionals-dels-biolegs/ 

¿Puede el cine espiritual ser también político? ¿Qué paisaje construye la cámara cuando decide borrar la historia? Una crítica demoledora a Sirât y a la deriva reaccionaria de la imagen en los festivales ✍🏼 Guillermo Martínez Valdunquillo ctxt.es/es/20250601/...

. + @bsc-cns.bsky.social

I wrote a short piece on how becoming an IgA Nephropathy patient has changed my perspective on biomedical research, developing an appreciation for the challenges in data interpretability & availability and the importance of patient engagement www.nature.com/articles/s41...

🌐BSC is a proud partner of EU CIP project, that aims to create a #CancerInfoPortal to improve health literacy, empower patients, and reduce inequalities in access to cancer care information across Europe.

Next July 4th in Lisbon come to this public event (please register in link provided). There will be a talk by Søren Brunak, discussion with @alfonsovalencia.bsky.social, Claudi Bockting, Jörg Menche, myself, and others. #ComplexSystems, #NetworkScience, #NetworkMedicine, #AI, #DigitalMedicine.

El algoritmo del Servicio Vasco de Salud para agilizar el diagnóstico del cáncer de piel, Quantus Skin, se equivoca en uno de cada tres melanomas y obvia a los pacientes con la piel oscura