Built by CATH, TÜM and NVIDIA, ProFam-1 is our new open-source protein family language model (pfLM) designed to generate functional protein variants and predict fitness using in-context example sequences.

It was lovely to speak at the CATH 30 symposium, celebrating 30 years of the @cathgene3d.bsky.social protein structure classification database. I was presenting recent work on our new generative protein-family language model: preprint coming soon.

Kickstarting our symposium “Protein Annotations in the age of AI” at UCL!

Congratulations @judewells.bsky.social!

CATH turns 30 years old this year! We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses. www.eventbrite.co.uk/e/protein-an...

Another CATH outing at Greenwich Park after a lovely cruise along the Thames and a pub lunch!

Our latest preprint is out on bioRxiv! A collaboration between the groups of @martinsteinegger.bsky.social , David Jones and Christine Orengo, we clustered AlphaFold Database and ESMatlas, a whopping 821 million proteins! We reveal biome-specific groups & over 11k novel domain combinations.

TED is a collaborative project between the structural bioinformatics groups of Professor David Jones & Professor Christine Orengo @cathgene3d.bsky.social at @ucl.ac.uk. The TED integration is set to enhance the interpretability and usability of #AlphaFold predictions. Is this useful in your work?

🚀 #AlphaFold Database update AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures. www.ebi.ac.uk/about/news/u... @pdbeurope.bsky.social

CATHmas lunch 2024!

A new version of CATH, v4.4, is out! 🎉 Here’s a link to the manuscript in NAR.

Hi TED! 👋 Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all! A joint effort with the Jones group at UCL Computer Science, here's a link to the article www.science.org/doi/10.1126/... 1/6 🧵⤵️

Hello 🦋! We are CATH! We classify protein domains in homologous superfamilies from the Protein Data Bank and AlphaFold Database! Follow us for our latest research!