Some diseases show up together. Others rarely appear in the same person This study looked into whether gene activity (from RNA data) can help explain why The answer: yes - more than we thought Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth Breakdown:

💻🧬'Los vínculos secretos que existen entre enfermedades. El estudio del BSC representa el mayor esfuerzo hasta la fecha para explicar científicamente las asociaciones clínicas entre enfermedades' 🗞En @innovaspain.bsky.social ➡ www.bsc.es/4kD @alfonsovalencia.bsky.social @beatrizurda.bsky.social

Excited to see our PNAS paper highlighted on Kudos, with an accessible take on the findings. Disease links are not random—they can be predicted from the expression of our genes. www.growkudos.com/publications... @pnas.org @alfonsovalencia.bsky.social 📄 doi.org/10.1073/pnas...

🧬 New research in PNAS shows how gene expression patterns reveal why some diseases occur together while others don’t. Scientists uncovered hidden links — with immune pathways playing a major role. #GeneExpression #Comorbidity #PrecisionHealth 🔗 www.news-medical.net/news/2025090...

Great #networkmedicine work by @alfonsovalencia.bsky.social's team on deriving comorbidity networks from RNA-seq data to study complex disease relationships. Thy show that molecular mechanisms are behind many of the known comorbidities (often via immune response). doi.org/10.1073/pnas...

No le habéis hecho mucho caso a esto, pero es muy, muy bonito. Y parece revolucionario. Seguro que volveremos a oír hablar de esto.

Totally! In our case it wasn’t even about sample size, but a basic textbook statistical concept 🤖. We even increased the sample size to show the results still held under the reviewer’s definition—and still, they wouldn’t budge.

Brutal. Investigadores usando el Centro Nacional de Supercomputación (BSC-CNS) han encontrado conexiones clínicas desconocidas (p.e. entre la enfermedad de Crohn y el desarrollo de úlceras), cosa que permitirá mejorar el tratamiento/medicación. Además, todos podemos ya ver toda esa (sigue 🧵)

Un nuevo método computacional, creado en el @bsc-cns.bsky.social y basado en datos de más de 4 000 pacientes y 45 patologías, identifica conexiones clínicas conocidas y sugiere asociaciones inéditas con posibles aplicaciones en el diagnóstico y los tratamientos. www.agenciasinc.es/Noticias/El-...

She explains part of the fight over 2 years with an absurd referee (can happen) and an incompetent profesional editor unable to understand even basic statistics - or worse unable to take a decision by him/her self. But never mind: Beatriz won and the paper is now published in a better journal.

Very happy to get it out. For scientific & personal reasons this one is special. Beatriz has done more work and endured the most difficult - and absurd - publications battles I can remember. Thanks to PNAS for being "normal" and congratulations to Beatriz. (Beatriz: next one will be easier!)

1/ Everything that could go wrong in paper publishing… did. A story of patience, absurdity, and persistence 🌀 <1min From Alfonso Valencia’s lab and a very stubborn PhD student (me).

🚨 New in PNAS! 🧬 64% of disease co-occurrences can be explained by transcriptomic similarities. Comorbidities aren’t random—they have a molecular basis. Here’s how we found it 👇 (1/n) 🔗 doi.org/10.1073/pnas.2421060122 @alfonsovalencia.bsky.social

🧬💻El BSC crea un método computacional que revela conexiones hasta ahora ocultas entre enfermedades. ℹMás info: www.bsc.es/4ke 💻 Acceder a la plataforma interactiva: disease-perception.bsc.es/rgenexcom/ 📄 Publicado en @pnas.org #supercomputación #IA #enfermedades

👏🏆 Congrats to our #NetBio2025 prize winners: - Best Talk: Beatriz Urda-García - Best Poster Method: Arne Wehling - Best Poster Application: Sebastian Urquiza-Zurich - Best Poster Tool: Estefania Torrejon Thanks to all the (poster) presenters!!! It's amazing to have you in our community!!

🎤 Next talk at #NetBio: @beatrizurda.bsky.social: Disentangling the genetic and non-genetic origin of disease co-occurrences #ISMBECCB2025 #NetworkBiology

🌐BSC is a proud partner of EU CIP project, that aims to create a #CancerInfoPortal to improve health literacy, empower patients, and reduce inequalities in access to cancer care information across Europe.

I’m really curious: what else will we need to act? Enter your location and be moved. showyourstripes.info/c/europe/spa...

🚬The molecular impact of cigarette smoking resembles aging across tissues ⭕This is the 1st comprehensive, multi-tissue analysis to show that smoking doesn’t just harm specific organs like the lungs 🫁 📄By BSC & Universidade do Porto researchers, published in Genome Medicine: bsc.es/Zt2

New research alert 📝❗❗❗ In our latest pre-print, 2nd of my PhD, we performed a Systematic Literature Review on the use of Deep Representational Learning (DRL), especially the Variational Autoencoder (VAE), in cancer progression research. This thread explains our main findings. (1 minute read)

The first year of school is when a maths gap between boys & girls emerges, according to a 4-year longitudinal assessment of language & mathematical performance of all French first and second graders (2,653,082 children!) We now know when to focus interventions 🧪 www.nature.com/articles/s41...

New Insights into Medulloblastoma! 🧠 I am very happy to announce the first paper in my Ph.D. thesis journey: Exploring the Boundaries of Medulloblastoma Subgroups with synthetic Data Generation -> www.biorxiv.org/content/10.1... Let’s dive in into our findings with this thread! 🧵⤵️