New research finds people with ME/CFS have a striking deficiency in vasopressin - a hormone that helps the body retain water. This could explain common symptoms like constant thirst and dizziness upon standing. Let's break down the findings.

Long COVID immune findings from a large clinical trial (STOP-PASC). Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms. Across many studies, Long COVID shows a shared pattern of ongoing immune activation.

2025 brought big new clues about Long COVID and ME/CFS: Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes. Here is an end of year round up in plain language.

New research shows major damage in the brain stress system of people with very severe ME/CFS. The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms. Let’s break it down in simple language.

New ME genetics study: using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes. Let’s break it down in simplified language. precisionlife.com/news-and-eve...

Mild COVID in monkeys caused long lasting changes in brain and body. Months later they still had problems with smell and taste, thinking, sleep and heart control. This looks similar to long COVID in people.

Whole blood RNA sequencing can identify which high risk COVID 19 patients are most likely to worsen and which ones respond best to sotrovimab. A similar method to what we aim to do in Long COVID and ME at @amaticahealth Paper breakdown 🧵

Anktiva is probably one of the most interesting drugs in trial for Long COVID. It works by raising key immune cells that seem low or poorly functioning in LC condition. This thread explains what the drug does and why researchers are testing it.

Igg autoimmunity in Long COVID & ME/CFS: Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.

Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule. This may allow a device called a GNA lectin filter to remove them. 🧵

We will be speaking tonight at 5pm GMT at the Renegade Research roundtable. We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more Everyone welcome - sign up: us06web.zoom.us/webinar/regi...

Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy A similar method to what we aim to do in Long COVID and ME at @amaticahealth Paper breakdown 🧵

New paper links EBV to Lupus. In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process Breakdown 🧵

Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later. A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join: amaticahealth.com Paper breakdown 🧵

New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.

New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths. Let’s break it down🧵

1/ New study tested blood from ME/CFS patients for 185 human viruses. Result: healthy controls had more viral DNA than patients (Unexpected). Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup. Let’s break it down🧵

🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A. Research shows these genes can help distinguish bacterial from viral infections. Let’s break down which clusters likely fall into each category.

🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw? According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function Here’s how it works and how it’s been done in research 🧵

How do mitochondria produce energy - and what happens when this process breaks down in disease? This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵

The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury. It's theorised as how your body begins healing. But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵

🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog. It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵

🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain. Let’s break it down 🧵 You can also test your RNA in blood here: amaticahealth.com/me-cfs-long-...

🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS. And into DecodeME findings. Simplified breakdown 🧵

🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw? According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function Here’s how it works and how it’s been done in research 🧵

Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream. This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself: amaticahealth.com/me-cfs-long-...

New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS TIGIT is found on immune cells like T & NK cells It helps regulate the immune system by acting as a "immune system brake" This can prevent the body from fighting cancer or infections effectively

A new study just showed that gut bacteria from people with fibromyalgia can cause pain when transplanted into mice. This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia. Here's a full breakdown of what they found

Some diseases show up together. Others rarely appear in the same person This study looked into whether gene activity (from RNA data) can help explain why The answer: yes - more than we thought Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth Breakdown:

New @amaticahealth preliminary findings: elevated NKG2A in Long COVID & ME/CFS NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses

New research shows Long COVID and chronic fatigue syndrome (ME/CFS) share the same biological problem: their bodies struggle to use oxygen properly during exercise. Here's a full breakdown - and what it means.

Reposting as important: 🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy. Surprisingly, we can track how this is going using blood RNA. Here’s what recent research has found in humans 🧵

🧵 T cell exhaustion - possibly one of the drivers of chronic infections in Long COVID & ME/CFS. What is it, what genes are involved, and how we can gain insights with available testing. Let’s break it down. 🧵

🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS. Importantly - patients separated into subgroups, a focus by us @amaticahealth Let’s break it down in simple language 🧵

🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS. Importantly - patients separated into subgroups, a focus by us @amaticahealth Let’s break it down in simple language 🧵

🔬Viruses don’t just cause short-term illness. Many stay in your body for life. They speed up the aging process - in your immune system, organs, and even your DNA. Here’s some examples, and why stopping them could help extend lifespan🧵

🔬Interesting aging study - removing a single protein (FTL1) from the brain of old mice restores memory and brain function. It also improves how brain cells use iron and energy. Aging reversal is hope for me losing years to chronic illness - let’s break it down.🧵

Natural Killer (NK) cells are an integral part of your immune system. They help get rid of infected or abnormal cells. Having been found altered in ME/CFS and Long COVID and predictive for treatments like Daratumumab. We can gain insights into NK cells through RNA sequencing🧵

🔬Most people think mast cells are only involved in allergies or rare conditions like MCAS or mastocytosis. That’s incorrect. Research shows mast cells are active in many diseases, including neurodegenerative, autoimmune, infectious, heart, gut, and mental health conditions🧵

🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy. Surprisingly, we can track how this is going using blood RNA - no need for tissue biopsies. Here’s what recent research has found in humans 🧵

A new study identifies a protein called SMPDL3B as a possible key factor in Myalgic Encephalomyelitis (ME/CFS). It could explain immune problems, symptom severity, and even point to new treatments. Here’s a full breakdown - our preliminary RNA data supports this finding: 🧵

🔬 A major international study looked at what COVID-19 does to your blood vessels over time. It found that people who had COVID - especially women - had “older” and stiffer arteries, even months later. Here’s a simplified breakdown of what they found 🧵

Chronic diseases face structural and clinical challenges that delay progress. Some of the most pressing: - Lack of research funding - Lack of large cohorts in research - Broad variation in symptoms and biology - Poor or harmful responses to many treatments

🔬 How can blood RNA hint if someone has an ongoing bacterial infection? Certain RNA patterns can indicate whether bacteria are present and how the immune system is responding Potentially useful for identifying bacterial persistence in Long COVID & ME/CFS 🧵

🔬Interesting new brainstem and cerebellum study in Long COVID - new imaging findings A new brain imaging study of Long COVID patients reveals major damage in key parts of the brain responsible for movement, balance, and automatic body functions like heart rate and sleep Let’s break it down🧵

Will make a effort to cross post now on threads, X, and bluesky If there are any other locations you would like me to post breakdowns and our research. Let me know!

Will make a effort to cross post now on threads and bluesky for everyone who doesn’t use X If there are any other locations you would like me to post breakdowns and our research. Let me know!

3 Biological Neuroimmune Subtypes in Post-COVID & ME/CFS 🔬❕ We mapped our @amaticahealth post-COVID + ME patients into three distinct biological clusters using Neuroimmune markers Cluster 1; mitochondrial stress Cluster 2; Non inflammatory Cluster 3; Neuro inflammatory 🧵 👇🏻

🧵We clustered our patients based on metabolic / O₂-sensing / mitochondrial markers. Two distinct subgroups appeared, showing potential differences in underlying metabolic function. We also looked at which other markers separated them. Here’s what we found 👇

Just sent in the initial contact to pursue Arginase 1 & HIF1a inhibitor compassionate use in #longcovid #mecfs for one of the patients in the Amatica study Very thankful we have physicians willing to pursue this Will provide updates as the process evolves!