Scientists engineered “helper” immune T cells to recognise Alzheimer plaque in mice. The cells piled up where plaque builds up around the brain. A short-lived version was linked to fewer brain plaques and lower inflammation signals. Early mouse proof of concept.

Long COVID blood signal in this study: Many more tiny “microclots” plus higher markers of some overactive white blood cells. The two also often show up stuck together in the same clumps. This pattern may help with measurement and subgrouping.

Some immunosuppressed blood cancer or blood disorder patients stayed COVID PCR positive for weeks to months after single antivirals. In this hospital cohort, 2 to 3 antivirals together was followed by PCR clearance in 13 of 15 followable episodes.

Brain scans in Long COVID found a brain fluid structure that was larger and had lower blood flow. These scan changes were linked to higher Alzheimer’s-related blood markers and small differences on thinking tests.

A 6-month randomised trial tested whether a Fitbit + pacing app could reduce post-exertional malaise (PEM) in long COVID. It was safe and well run, but it did not improve PEM more than usual care.

Replication update in mostly moderate, non-PEM sampling: the 2016 “ME/CFS serum changes muscle cell respiration” signal wasn’t reproduced in this assay. Useful to narrow focus, but it doesn’t cover severe ME/CFS or blood drawn during PEM.

New study: People with ME/CFS and Long COVID show a clear drop in how their bodies make energy after exertion. This drop appears on repeat testing, and not just from being unfit.

Viruses appear to play a meaningful role in aging. Across a lifetime, infections may speed up immune aging, increase long-term inflammation, and raise the risk of age-related diseases.

Many diseases were once called “psychological” or “all in the mind”. Again and again, biology later proved otherwise. This thread shows clear cases where medicine got it wrong, then changed its mind once real mechanisms were found.

A blood protein often found elevated in Alzheimer’s patients rose ~59% after COVID, but only in people with long-lasting neurological symptoms. This study tracked people before and after COVID and found the signal wasn’t there before infection.

Brain scans in ME/CFS and Long COVID have found changes in glutamate and GABA, the chemicals that control brain activity. Multiple studies now suggest disrupted excitation and inhibition may be linked to brain fog, fatigue, and sensory symptoms. Let’s breakdown in simple terms.

New Google DeepMind AlphaGenome paper: an AI reads 1,000,000 DNA letters at once and predicts lab-style genome signals down to single letters. What this means: it may help turn “unknown” non-coding variants into testable guesses about which genes or processes they affect.

New ME/CFS + fibromyalgia study: Patients had higher “OPRM1” DNA methylation (a gene control tag that can reduce gene activity, how on or off genes are). This supports the idea the body’s own opioid pain-control system may be altered in these illnesses.

Long COVID blood clue: tiny “packages” in serum (extracellular vesicles, EVs) contained fragments of SARS-CoV-2 proteins in many samples, even long after infection. This could help explain why symptoms can persist and may offer a biomarker.

Scientists just mapped tiny veins across the entire living human brain in under 7 minutes using ultra-high resolution MRI. Previously this kind of detailed view was mainly built from postmortem (after death) methods. Here’s what they did and why it matters.

ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) is a serious, chronic, multi-system disease. It is not “just being tired” The hallmark problem is exertion intolerance: activity can trigger a delayed worsening of symptoms, known as PEM Breakdown in simple language 🧵

Breakdown of our Health Rising interview: we’re building one of the biggest Long COVID + ME/CFS biology datasets yet, using a blood test that reads ~20,000 gene activity signals plus a 350-question symptom map. The aim is to find subgroups and speed up treatments that may actually fit.

Long COVID brain fog may have a measurable brain energy signal. A whole brain scan found lower ATP/PCr (ATP = main energy molecule in cells, PCr = fast energy backup) in the cingulate cortex, and in the anterior cingulate, lower values lined up with worse cognitive test scores.

EBV and MS: a shared T cell target (ANO2). This study finds about 57% of people with MS have CD4 T cells that react to ANO2. Some of those T cells also react to EBV EBNA1. In mice, ANO2-focused T cells were linked to worse MS-like disease.

ME/CFS immune cell lines show unusual fat buildup. One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls. Many triglycerides, diglycerides, and fatty acids are higher. A lipid enzyme PTDSS1 is higher too. Paper by @DanMissailidis & Co

New research on ME/CFS finds unusual cell signals after exercise. Tiny packages released by cells (extracellular vesicles) show problems with energy production, an overactive immune system, and cell stress. Let’s break it down in simple terms.

New analysis suggests treating COVID-19 right at its entry point (nose & throat) can slow or stop the virus early. Using simple nasal sprays or gargles (like iodine solution or salt water) early on might lower the risk of severe illness.

For the first time, scientists have reversed advanced Alzheimer’s disease in mice - fully restoring memory and repairing brain damage by targeting the brain’s energy supply.

Microclots and protein chemical changes: separating pre-COVID POTS, Long COVID, and Long COVID POTS. Microclot counts were not clearly different after strict stats. Protein amounts barely changed. But PTMs (chemical changes on proteins) inside microclots differed a lot.

Lab-grown mini muscles showed that blood from people with chronic fatigue syndrome (ME/CFS) and Long COVID can directly weaken and damage muscle cells. The muscles first tried to adapt their energy use, then became fragile and lost strength.

New research finds people with ME/CFS have a striking deficiency in vasopressin - a hormone that helps the body retain water. This could explain common symptoms like constant thirst and dizziness upon standing. Let's break down the findings.

Long COVID immune findings from a large clinical trial (STOP-PASC). Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms. Across many studies, Long COVID shows a shared pattern of ongoing immune activation.

2025 brought big new clues about Long COVID and ME/CFS: Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes. Here is an end of year round up in plain language.

New research shows major damage in the brain stress system of people with very severe ME/CFS. The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms. Let’s break it down in simple language.

New ME genetics study: using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes. Let’s break it down in simplified language. precisionlife.com/news-and-eve...

Mild COVID in monkeys caused long lasting changes in brain and body. Months later they still had problems with smell and taste, thinking, sleep and heart control. This looks similar to long COVID in people.

Whole blood RNA sequencing can identify which high risk COVID 19 patients are most likely to worsen and which ones respond best to sotrovimab. A similar method to what we aim to do in Long COVID and ME at @amaticahealth Paper breakdown 🧵

Anktiva is probably one of the most interesting drugs in trial for Long COVID. It works by raising key immune cells that seem low or poorly functioning in LC condition. This thread explains what the drug does and why researchers are testing it.

Igg autoimmunity in Long COVID & ME/CFS: Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.

Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule. This may allow a device called a GNA lectin filter to remove them. 🧵

We will be speaking tonight at 5pm GMT at the Renegade Research roundtable. We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more Everyone welcome - sign up: us06web.zoom.us/webinar/regi...

Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy A similar method to what we aim to do in Long COVID and ME at @amaticahealth Paper breakdown 🧵

New paper links EBV to Lupus. In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process Breakdown 🧵

Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later. A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join: amaticahealth.com Paper breakdown 🧵

New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.

New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths. Let’s break it down🧵

1/ New study tested blood from ME/CFS patients for 185 human viruses. Result: healthy controls had more viral DNA than patients (Unexpected). Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup. Let’s break it down🧵

🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A. Research shows these genes can help distinguish bacterial from viral infections. Let’s break down which clusters likely fall into each category.

🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw? According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function Here’s how it works and how it’s been done in research 🧵

How do mitochondria produce energy - and what happens when this process breaks down in disease? This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵

The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury. It's theorised as how your body begins healing. But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵

🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog. It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵

🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain. Let’s break it down 🧵 You can also test your RNA in blood here: amaticahealth.com/me-cfs-long-...

🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS. And into DecodeME findings. Simplified breakdown 🧵

🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw? According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function Here’s how it works and how it’s been done in research 🧵