The detectCores() apocalypse is creeping up on us 👻🐛 As more people are getting access to 128+ CPU cores, code spinning up parallel cluster with detectCores() workers fails - not enough #RStats connections available Friends, do *not* default to detectCores(), bc www.jottr.org/2022/12/05/a...

🚀 philentropy v0.10.0 is on CRAN! Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown. Compute 50+ distances/divergences in R faster than ever. 📦 CRAN: cran.r-project.org/web/packages... 💻 Code: github.com/drostlab/phi...

DIAMOND v2.1.15 now supports all taxonomy features for BLAST databases, and support for using BLAST databases has also been added to the Bioconda version github.com/bbuchfink/di...

What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵

Tomorrow wednesday 22nd at 11am, lesson #2 of Neil Shubin, Guest Prof @college-de-france.fr ‘Discovering how fish evolved to walk’. Wonderful first lesson @ www.youtube.com/watch?v=0B6y... Fish friends in Paris, please RT🤘 Swim the Seine till St Michel, then get out and walk left. Free access

It has been a true honour and pleasure to be able to brainstorm about what it means to apply the comparative method to detect common patterns of multicellularity aggregation across the trees of life. This was a marvelous EMBO Workshop, excetionally well organised and held at a breathtaking venue! 😌

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Thrilled to share what we learned from re-annotating the mobilome of the brown algae model [Ectocarpus] 🌊🌿🏖️ genomebiology.biomedcentral.com/articles/10.... A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉

In memory of Jane Goodall, English primatologist and anthropologist and the world's foremost expert on chimpanzees. Take a look at her 1985 article published in #PhilTransB 'Conditions of innovative behaviour in primates': royalsocietypublishing.org/doi/10.1098/...

So happy to see my first first-author paper published! 🎈 A short thread on how Ectocarpus and its TE secrets have kept me busy lately: rdcu.be/eITQH

🚀 Jalview 2.11.5 is here! New features include: ✅ Tree visualisation for enhanced protein secondary structure analysis ✅ Consensus colouring for alignments and subgroups ✅ Improved command line options for 3D structure visualisation Plus, key bug fixes and performance improvements.

Hot damn "The settlement is largest payout in the history of U.S. copyright cases. Anthropic will pay $3,000 per work to 500,000 authors."

Out after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis! www.nature.com/articles/s41...

Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate. It is an honour to have contributed to this 20y struggle ⛰️.

'Hoods are out!!! Big thank you to @plantevolution.bsky.social for the support throughout. Luisa, @kdm9.bsky.social , @aconga.bsky.social , @hajkdrost.bsky.social it was intellectually stimulating ride with you, so congratulations!!!! #diversity #NLR #immune #pan-genome #graphs #networktheory

Out after peer review now, follow up from our 2019 pna-NLRome paper (which was based on enrichment and long-read sequencing). It is remarkable how much more can be learned with complete genome sequences. Next. pan-NLRome from hundreds of A. thaliana long-read genomes! Big thanks to the entire team!

Happy to be able to finally share our NLR pangenome paper, out now in CHM. "Pangenomic context reveals the extent of intraspecific plant NLR evolution" www.cell.com/cell-host-mi... #plantscience #plantimmunity #pangenomes #science #nlr

Deadline was just extended to 30th March! :)

Kind reminder that if you would like to learn more about the fundamental principles of embryo formation, please apply for this PhD post by 21st March :)

Please spread the word🙏: [PhD Position in Computational Evolutionary Transcriptomics] If you are interested in doing a PhD in gorgeous Scotland on 'Why embryo development goes wrong sometimes?', please consider applying and join our wonderful team in Dundee! www.dundee.ac.uk/phds/opportu...

I sometimes wonder what a world would look like in which each incremental post was 1% better or more considered than the previous. Starting to populate yet another social network seams like a good way to test this for me personally. Happy to be here now :)