New Correspondence: "Rethinking the need for field trials" rdcu.be/eM96P

2/2 Our lab pioneered the use of genome graphs already 16 years ago! Read this oldie-but-goldie from @labschneeberger.bsky.social and Jörg Hagmann: Simultaneous alignment of short reads against multiple genomes genomebiology.biomedcentral.com/articles/10....

1/2 Want to become up to date with pangenomes and genome graphs and their history? Check out this fantastic review by @zbao.bsky.social! Complexity welcome: Pangenome graphs for comprehensive population genomics #pangenomes #plantscience #genomegraphs www.cambridge.org/core/journal...

@annaliisalaine.bsky.social Does this look familiar to you? From Cherokee National Forest

Out after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis! www.nature.com/articles/s41...

Plant NLR evolution Annotated, divergent A. thaliana genomes &pangenome graph approaches describe genomic neighborhoods of NLRs, revealing evolutionary footprints in form of “diversity in diversity” at these loci Weigel @mpi-bio-fml.bsky.social @coevolution.bsky.social‬ www.cell.com/cell-host-mi...

~ 5 and 1/2 years ago, my then postdoc advisor @plantevolution.bsky.social gave me complete freedom to assemble a team and interrogate NLR diversity in pangenomic context. We used @pacbio.bsky.social CCS and Iso-Seq, to annotate genomes with pathogen-challenged transcriptome. We then manually.....

Out after peer review now, follow up from our 2019 pna-NLRome paper (which was based on enrichment and long-read sequencing). It is remarkable how much more can be learned with complete genome sequences. Next. pan-NLRome from hundreds of A. thaliana long-read genomes! Big thanks to the entire team!

1/2 What's best: a field-first or lab-first approach? No easy answers but differences between lab and field should not be seen as failure but motivate further inquiry and allow complementary discovery. Read our thoughts on this here: www.sciencedirect.com/science/arti...

Feel free to ask any q's here

We show that pangenome graphs provide a flexible way to define the context within which NLR evolution occurs, and that graph metrics capture diversity in both sequence and structure, and show that such diversity is centered on NLRs themselves

Long story short: we assemble 17 representative Arabidopsis thaliana genomes, exhaustively annotate NLRs with long read evidence & manual curation, and assay many measures of NLR diversity.

'Hoods are out!!! Big thank you to @plantevolution.bsky.social for the support throughout. Luisa, @kdm9.bsky.social , @aconga.bsky.social , @hajkdrost.bsky.social it was intellectually stimulating ride with you, so congratulations!!!! #diversity #NLR #immune #pan-genome #graphs #networktheory

Come join EEB at the University of Tennessee at Knoxville. Evolutionary Genomics, Assistant Professor, Ecology & Evolutionary Biology, Fall 2026 apply.interfolio.com/170735 functional and evolutionary genomics in any system 🌱, 🦠, or 🦌 (including 👫)

I am Grape!

#MemPanG25 @thinks.lol

In the Smokies, on a wild grape hunt

1/6 Today is Labor Day in USA and we decided to release the results of our labor and rigor on NLR evolution as a preprint. www.biorxiv.org/content/10.1...

Wild Flower Festival, Frozen Head State Park, #TN #statepark #TNPS, Tennessee Native Plant Society #naturalist

Wild Flower Festival, Frozen Head State Park, #TN #statepark #TNPS, Tennessee Native Plant Society #naturalist

Wild Flower Festival, Frozen Head State Park, #TN #statepark #TNPS, Tennessee Native Plant Society #naturalist