Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup

Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach. tinyurl.com/n2k3md9e

Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance. tinyurl.com/ybv5e9ft

Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres. tinyurl.com/bdfprjcn

Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky academic.oup.com/brain/advanc...

September's issue of Brain is now online! academic.oup.com/brain/issue/...

Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2

Super stoked to share our paper just out in Brain @brain1878.bsky.social LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. tinyurl.com/4k8hr3bj

From signal to senescence: IFNγ drives muscle atrophy in myositis New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f

Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy. tinyurl.com/h658b3f2

August's issue of Brain is now online! academic.oup.com/brain/issue/...

Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5

Disentangling epilepsy and dementia: more to do, together New scientific commentary by Arjune Sen tinyurl.com/mr44jt9b

I’m delighted to share my editorial for the July issue @brain1878.bsky.social academic.oup.com/brain/articl...

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45

Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide New scientific commentary by Laura Wisse and Renaud La Joie tinyurl.com/345u5r3w

The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease New scientific commentary by Ryan Coburn and Hugo Botha tinyurl.com/3ffhrkm7

Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis. tinyurl.com/bddyanm4

In a NEW STUDY, researchers Chaitali Anand, Justin Torok,, Ashish Raj, et al. at UCSF reveal how genes influence where & how #Alzheimers - related tau protein spreads in the brain. Learn More @brain1878.bsky.social academic.oup.com/brain/advanc...

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45

Proelss et al. describe the mapping of human genital representations by electrical stimulation of somatosensory cortex. Males but not females report genital sensations in response to stimulation of the postcentral gyrus. tinyurl.com/2xptrtfs

Moschovaki-Filippidou et al. show that an exon skipping morpholino targeting Dnm2 splicing reduces intact Dmn2 mRNA and protein levels in muscle, and restores muscle force, in a centronuclear myopathy mouse model. tinyurl.com/3hth9csf

Graham et al. used biomarkers to investigate the effects of TBI in mid-life former elite rugby players. Compared to unexposed controls, these individuals showed elevated plasma p-tau217 levels and reduced volumes in frontal and anterior cingulate cortex. tinyurl.com/j8emw6d3

Pathogenic variants in CLCN3 and CLCN4—which encode the 2Cl-/H+ exchangers ClC-3 and ClC-4—cause rare neurodevelopmental disorders. Qi et al. show that ClC-3/ClC-4 regulate neuronal excitability and firing patterns by fine-tuning Kv7/KCNQ channel density. tinyurl.com/2tbpdevh

July's issue of Brain is now online! academic.oup.com/brain/issue/...

TDP-43 aggregates play a key role in nerve cell loss in ALS and FTD. Ervilha Pereira et al. highlight new genetic data showing that TDP-43 also plays a role in muscle function and disease. tinyurl.com/2uy95axn

Sun et al. generate a transcriptomic map of the developing human leptomeninges by analysing more than 27 000 single-cell transcriptomes from tissues spanning different fetal stages. tinyurl.com/3z7cj7pc

Bellanti et al. have developed an ultrasensitive assay for periaxin, a biomarker of peripheral nerve demyelination. When used alongside existing tests, the assay has the potential to improve the clinical management of peripheral neuropathy. tinyurl.com/4rbwjh67

Chen et al. present a composite model that uses genetic and microRNA markers to differentiate patients with migraine from controls, and to distinguish between the ictal and interictal phases of migraine. tinyurl.com/4dd8e5vv

Ketamine can alleviate depressive symptoms within hours, with the effects of a single dose lasting for days. Costi et al. review the mechanisms underlying the rapid antidepressant effects of ketamine in humans and animal models. tinyurl.com/mtwy2s4f

Using cellular models of human brain development, Benoit et al. show that POU3F2 – a transcription factor implicated in neurodevelopmental disorders – enhances canonical Wnt signalling. tinyurl.com/3s94ra2u

The dystonin gene encodes three major isoforms: DST-a, -b, and -e. Jacob et al. report that variants exclusively affecting DST-b cause an autosomal recessive congenital myopathy, while variants that also affect DST-a cause a lethal contracture syndrome. tinyurl.com/3p99pu9j

Maroni et al. show that partial loss of the histone lysine methyltransferase DOT1L disrupts synaptic gene transcription, alters neuronal morphology, and leads to sex-specific deficits in social behaviour. tinyurl.com/3ub4krn6

Benacom et al. show that transient disruption of perineuronal nets in primary motor cortex temporarily impairs motor function in healthy mice, but facilitates motor recovery in a Parkinson’s disease model. tinyurl.com/b7kaba4t

Hvingelby et al. show that reduced cholinergic activity in locomotor-related areas of the brainstem is associated with more severe freezing of gait in people with Parkinson’s disease, but only when they are in the ON motor state. tinyurl.com/yjwrmkjc

He et al. recorded neural activity from the motor cortex and thalamus, along with hand tremor signals, in people with essential tremor. Their findings provide new insights into the cortico-thalamic network involved in tremor generation. tinyurl.com/4b3ppah2

Using post-mortem in situ MRI, Wesseling et al. show that brain donors with LATE-NC have lower amygdalar and hippocampal volumes than non-LATE-NC donors, even when correcting for regional phosphorylated tau, amyloid-beta, and alpha-synuclein. tinyurl.com/34p435bd

Yang et al. propose that psychedelics hold untapped potential for improving stroke recovery through their ability to modulate neuroplasticity, reduce neuroinflammation, and enhance cognitive and psychological resilience. tinyurl.com/mzcvjyn

Drawing on two decades of clinical experience with affective disorders, Jesús Ramírez-Bermúdez— runner up in the Brain Essay Competition—explores the cultural significance of melancholy. tinyurl.com/4tmw6buk

Othman et al. studied the impact of apomorphine and methylphenidate on consciousness biomarkers and clinical arousal in ICU patients with brain injury, in a randomized placebo-controlled trial. tinyurl.com/5w3j58pt

Scarmeas & Noriega De La Colina use the ancient Greek concepts of nosos (biological disease) and asthenia (functional decline) to frame the shift in AD diagnosis from clinical symptoms to biomarkers. tinyurl.com/fyj2zumk

Fernández-Eulate et al. describe the clinical and genetic spectrum, along with the natural history, of BAG3-related neuromuscular diseases in Europe. tinyurl.com/mthk3hwm

By analysing functional connectivity within medial temporal lobe networks, Chauveau et al. provide evidence that hyperconnectivity within the anterior-temporal network is key to the pathophysiology and progression of Alzheimer's disease. tinyurl.com/3h6m5mfw

Jiang et al. find that proteasome dysfunction occurs early in Alzheimer’s disease and worsens with disease progression, impairing the ability of neurons to clear harmful proteins. tinyurl.com/4zbeprjf

Zhang et al. show that in cerebral small vessel disease, the oxygen extraction fraction first increases and then decreases, suggesting an initial compensatory response that gradually fails with disease progression. tinyurl.com/3ckfnmdh

Based on an analysis of 24 PMP22 variants in 50 patients with CMT1E, Ward et al. show that disease severity correlates with the extent to which the variants impair trafficking of PMP22 to the plasma membrane. tinyurl.com/3amj7aed

RVCL is a rare genetic disease of small blood vessels that can cause blindness, dementia, and organ failure. McGlasson et al. show that RVCL arises when mutations cause the enzyme TREX1 to mislocalize to the nucleus of endothelial cells, where it causes DNA damage. tinyurl.com/jdh9wpre

Hecht et al. performed side-by-side monitoring of spreading depolarizations and brain tissue oxygen in ischaemic stroke, and concluded that an absent or reduced brain tissue oxygen response to spreading depolarization signals tissue-at-risk. tinyurl.com/y8wesu2c

Matt Butler, runner up in the Brain Essay Competition, considers what happens when memories fragment and certainties fade in this fictional tale of a professor of literature who loses her grasp on time. tinyurl.com/2kpdwvcm