Brain
@brain1878.bsky.social
📤 457
📥 15
📝 273
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878.
Defining neurological disease is less objective than often assumed. Simon Shorvon considers how confusion between symptoms and disease, shifting criteria, unstable classifications, and complex aetiology can undermine the medical model.
tinyurl.com/5n8anfsc
14 days ago
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Although new Alzheimer's disease therapies reduce amyloid plaques, they have not led to major clinical improvements. Pini et al. suggest that changes in brain connectivity may offer a more sensitive and biologically meaningful marker of disease modification.
tinyurl.com/32975se3
16 days ago
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Thalamic highways as a bridge to neuromodulation New scientific commentary by David Burdette, Bahram Sarvi Zargar & Paul Ferrari
tinyurl.com/bdhh28dn
21 days ago
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White matter changes in Alzheimer's disease: contributor, consequence or co-pathology? New scientific commentary by Julia Neitzel
tinyurl.com/3x5ezsrc
21 days ago
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December's issue of Brain is now online!
academic.oup.com/brain/issue/...
23 days ago
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One third of stroke survivors experience vision loss. Raffin et al. present a non-invasive brain stimulation technique targeting visual pathways and show that it improves perception and expands visual fields.
tinyurl.com/yhppvzkv
26 days ago
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De Marchi et al. used FDG-PET and machine learning to examine neuropsychological and metabolic differences across the ALS-FTD spectrum, revealing distinct cognitive profiles and patterns of brain hypometabolism.
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Profiling cognition and brain metabolism in amyotrophic lateral sclerosis and frontotemporal dementia
De Marchi et al. used [18F]FDG-PET and machine learning to examine neuropsychological and metabolic differences across the ALS-FTD spectrum. Their findings
https://tinyurl.com/yvjwcfd6
27 days ago
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Koch et al. review motor skill learning and sensorimotor adaptation after stroke, highlighting ways in which lesion location, recovery stage, and individual differences affect learning, and offering recommendations for future research.
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Motor learning after stroke: what we’ve learned and what lies ahead
Many stroke survivors experience motor impairments that limit their daily activities. Koch et al. review motor skill learning and sensorimotor adaptation a
https://tinyurl.com/yssp4w92
29 days ago
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Weisman et al. critically examine the claim that pain can exist purely in the mind, without any physical trigger in the body, arguing instead that nociception is necessary – but not sufficient – for pain.
tinyurl.com/yw88waba
30 days ago
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reposted by
Brain
AJ Lees
about 1 month ago
To commemorate the bicentenary of Jean-Martin Charcot's life. Without him Neurology would be a different speciality.
@uclqsion.bsky.social
@brain1878.bsky.social
@masudhusain.bsky.social
academic.oup.com/brain/articl...
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Charcot redux
Jean-Martin Charcot was born in Paris on 29 November 1825. To mark the bicentenary of his birth, the International Society for the History of the Neuroscie
https://academic.oup.com/brain/article/doi/10.1093/brain/awaf386/8286256
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Cortical cerebral microinfarcts spark cognitive decline New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw:
tinyurl.com/nhrr7fek
about 1 month ago
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reposted by
Brain
Pain Research Forum
about 1 month ago
Are you familiar with immunoglobulin G’s pathophysiological role in fibromyalgia? Check out Israel et al.’s article in @brain1878.bsky.social, and Allan Basbaum’s comment on his view of this paper to find out!
bit.ly/47B1fii
#PRF
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Choo et al. show that damage to the medial temporal lobe – particularly the hippocampus – reduces the precision of memory for fine visual details, underscoring the role of this region in maintaining the fidelity of visual working memory representations.
tinyurl.com/t2jxztz7
about 2 months ago
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November's issue of Brain is now online!
academic.oup.com/brain/issue/...
about 2 months ago
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Mukherjee et al. review how ageing affects remyelination in MS. While most studies suggest remyelination capacity decreases with age, findings are sometimes inconsistent, and remyelination remains possible at any age.
tinyurl.com/c2ynpfrj
2 months ago
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Togo et al. show strong electrophysiological links between the hippocampus and both the anterior and posterior thalamus, along with robust connections between thalamic subregions.
tinyurl.com/5c6n23xj
2 months ago
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Kollenburg et al. review the molecular mechanisms and regional activity patterns underlying headache disorders including migraine, cluster headache, and paroxysmal hemicrania.
tinyurl.com/46aafjxu
3 months ago
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reposted by
Brain
Masud Husain
3 months ago
The current environment is making it near impossible to run clinical trials in the UK. One key issue discussed in
@brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities. My views on how to change the system
academic.oup.com/brain/articl...
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Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI.
tinyurl.com/a6rxvbey
3 months ago
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New issue of Brain now online!
tinyurl.com/mwxp6x24
3 months ago
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Avalos-Alais et al. present a high-resolution probabilistic map of bidirectional effective connectivity between the human lateral PFC and widespread cortical and subcortical regions, based on analysis of intracranial evoked potentials.
tinyurl.com/br7htec9
3 months ago
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Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD.
tinyurl.com/3sz8ayup
3 months ago
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Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach.
tinyurl.com/n2k3md9e
3 months ago
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Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance.
tinyurl.com/ybv5e9ft
4 months ago
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Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres.
tinyurl.com/bdfprjcn
4 months ago
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reposted by
Brain
Katrin Pape
4 months ago
Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in
#MultipleSclerosis
out in
@brain1878.bsky.social
today. Thanks to everyone involved in this great team work!
@neurologymainz.bsky.social
@toszkabohn.bsky.social
#ImmunoSky
academic.oup.com/brain/advanc...
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Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis
Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf268/8240838?searchresult=1
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September's issue of Brain is now online!
academic.oup.com/brain/issue/...
4 months ago
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Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND.
tinyurl.com/fcjpywx2
4 months ago
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reposted by
Brain
Jacob Vorstman
5 months ago
Super stoked to share our paper just out in Brain
@brain1878.bsky.social
LoF variants in DENND2B give rise to an autosomal dominant neurodevelopmental condition characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia.
tinyurl.com/4k8hr3bj
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Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia
Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characte
https://tinyurl.com/4k8hr3bj
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From signal to senescence: IFNÎł drives muscle atrophy in myositis New scientific commentary by Werner Stenzel et al.
tinyurl.com/33hwhd8f
5 months ago
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Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy.
tinyurl.com/h658b3f2
5 months ago
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August's issue of Brain is now online!
academic.oup.com/brain/issue/...
5 months ago
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Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms.
tinyurl.com/3u4ufv2z
5 months ago
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Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions.
tinyurl.com/3a2auah5
5 months ago
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Disentangling epilepsy and dementia: more to do, together New scientific commentary by Arjune Sen
tinyurl.com/mr44jt9b
5 months ago
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reposted by
Brain
Rimona Weil
6 months ago
I’m delighted to share my editorial for the July issue
@brain1878.bsky.social
academic.oup.com/brain/articl...
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Seeing the trees in the wood: the importance of co-pathologies in Alzheimer’s disease and dementia with Lewy bodies
Our understanding of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) owes a debt to pioneering work by Emil Kraepelin, Franz Nissl, Alois Alzh
https://academic.oup.com/brain/article/148/7/2233/8191311
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Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance.
tinyurl.com/3b7msy45
5 months ago
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Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide New scientific commentary by Laura Wisse and Renaud La Joie
tinyurl.com/345u5r3w
5 months ago
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The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease New scientific commentary by Ryan Coburn and Hugo Botha
tinyurl.com/3ffhrkm7
5 months ago
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Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis.
tinyurl.com/bddyanm4
6 months ago
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reposted by
Brain
The Pasinetti Lab
6 months ago
In a NEW STUDY, researchers Chaitali Anand, Justin Torok,, Ashish Raj, et al. at UCSF reveal how genes influence where & how
#Alzheimers
- related tau protein spreads in the brain. Learn More
@brain1878.bsky.social
academic.oup.com/brain/advanc...
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Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome
Anand et al. show that Alzheimer's disease risk genes confer vulnerability or resilience to tau pathology through both network-dependent and independent me
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf179/8189045
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Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance.
tinyurl.com/3b7msy45
6 months ago
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Proelss et al. describe the mapping of human genital representations by electrical stimulation of somatosensory cortex. Males but not females report genital sensations in response to stimulation of the postcentral gyrus.
tinyurl.com/2xptrtfs
6 months ago
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Moschovaki-Filippidou et al. show that an exon skipping morpholino targeting Dnm2 splicing reduces intact Dmn2 mRNA and protein levels in muscle, and restores muscle force, in a centronuclear myopathy mouse model.
tinyurl.com/3hth9csf
6 months ago
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Graham et al. used biomarkers to investigate the effects of TBI in mid-life former elite rugby players. Compared to unexposed controls, these individuals showed elevated plasma p-tau217 levels and reduced volumes in frontal and anterior cingulate cortex.
tinyurl.com/j8emw6d3
6 months ago
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Pathogenic variants in CLCN3 and CLCN4—which encode the 2Cl-/H+ exchangers ClC-3 and ClC-4—cause rare neurodevelopmental disorders. Qi et al. show that ClC-3/ClC-4 regulate neuronal excitability and firing patterns by fine-tuning Kv7/KCNQ channel density.
tinyurl.com/2tbpdevh
6 months ago
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July's issue of Brain is now online!
academic.oup.com/brain/issue/...
6 months ago
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TDP-43 aggregates play a key role in nerve cell loss in ALS and FTD. Ervilha Pereira et al. highlight new genetic data showing that TDP-43 also plays a role in muscle function and disease.
tinyurl.com/2uy95axn
6 months ago
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Sun et al. generate a transcriptomic map of the developing human leptomeninges by analysing more than 27 000 single-cell transcriptomes from tissues spanning different fetal stages.
tinyurl.com/3z7cj7pc
6 months ago
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Bellanti et al. have developed an ultrasensitive assay for periaxin, a biomarker of peripheral nerve demyelination. When used alongside existing tests, the assay has the potential to improve the clinical management of peripheral neuropathy.
tinyurl.com/4rbwjh67
6 months ago
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