Saini et al. report no evidence of genetic interaction between SNCA and APOE in 8855 synucleinopathy patients and 11 067 controls. The authors found no evidence of genetic epistasis between these genes 👉 buff.ly/PER2aEq

Albanese et al. report on a peculiar and rare phenotype observed in a tertiary movement disorders centre. The patients presented a functional movement disorder with sustained shoulder elevation posture, frequent pain, and no identifiable cause 👉 buff.ly/hCd1juP

Jiang et al. showed that 5-year follow-up data from 102 children with 5q-spinal muscular atrophy who received disease-modifying therapy revealed improvements in motor function, growth status and frequency of complications 👉 buff.ly/ZYR1KhD #neuroscience

Proitsi et al. report that lipidomic network analysis of post-mortem brain tissue reveals increased levels of phospholipids and sphingomyelins in Alzheimer’s disease brain donors, especially in carriers of rare TREM2 risk variants 👉 buff.ly/8v361eW

Jayasekera et al. report that peri-tumoural regions harbouring ex vivo evidence of epileptogenicity in the form of interictal discharges have excess cortical glutamate as measured by magnetic resonance spectroscopy 👉 buff.ly/IZoWpbA

Özbay et al. demonstrated that intranasal administration of peptides targeting melanocortin 4 and ghrelin receptors can modulate food intake in mice. Their study shows that selected peptides successfully reach the hypothalamus 👉 buff.ly/w5Rnixy

Cody, et al., use temporal modelling to show that Alzpath and Lilly plasma p-tau217 can provide individualized estimates of p-tau217 positive age and time 👉 buff.ly/1XxoCFl #Alzhimers

Perivascular space dysfunction has been proposed to be a pathogenic mechanism in amyotrophic lateral sclerosis (ALS). Hsueh et al. reported that changes and dysfunction in imaging parameters may contribute to the clinical manifestations of ALS 👉 buff.ly/eaS1Pkv

Cabello Fernandez et al. report that two psychoeducation interventions (cognitive versus affective) tailored to cognitive, functional and psychological difficulties in Long COVID were well-received and beneficial 👉 buff.ly/GWe7HMg #COVID

Serum glial fibrillary acidic protein, neurofilament light chain and Growth/differentiation factor-15s were increased in the chronic stage of Leber hereditary optic neuropathy and autosomal-dominant optic atrophy 👉 buff.ly/1a3qEpb

Nestor et al. deployed a portable, handheld neuronavigation-guided low-intensity ultrasound system in a single-arm safety and feasibility study involving 12 Alzheimer’s participants treated 4× with 30–100 sonications at a 1.95 MPa dose 👉 buff.ly/ryCPeLd #Alzhimers

Helena Verhelst and Emma M. Karlsson report that developmental dyslexia is associated with inconsistent and regionally atypical hemispheric lateralization for language, rather than weaker or absent asymmetry 👉 buff.ly/APFl1WX #dyslexia

Diachenko et al. report an electroencephalography-based marker for tracking early-stage hyperexcitability in Alzheimer's disease. In an Alzheimer's mouse model, recordings revealed early-stage frequency-specific shifts towards excitatory dominance 👉 buff.ly/dpxqHbZ

Pisano et al. show neurite orientation dispersion and density imaging diffusion magnetic resonance imaging reveals distinct microstructural patterns in dementia variants, developing a machine-learning model that classified subtypes with 97.3% accuracy 👉 buff.ly/S0tDJBn

Vidinopoulos et al. (2025) report that mechanical ventilation for 24 h preceded by intratracheal endotoxin exposure amplifies inflammatory proteins systemically and causes inflammation of brainstem respiratory-related centres in preterm foetal sheep 👉 buff.ly/928YYNy

This study demonstrates that former American football players showed localized shape alterations in the hippocampal, amygdala and selective thalamic changes relative to controls. Read at 👉 buff.ly/4NDfN6B

Toker and Monti report that rare causes of disorders of consciousness, including infections, autoimmune conditions and neurodegenerative diseases, target the same brain circuits as common causes. Read at 👉 buff.ly/pyeQKIJ

Capitani et al. review the relationship between the Human Leukocyte Antigen system and Alzheimer’s disease, presenting five perspectives; genetic association, HLA class I in the brain, infection hypothesis, antigen presentation and T-cell responses 👉 buff.ly/6iytQ4N #Alzhimers

Zhu et al. report that in cognitively unimpaired adults, sleep architecture is differentially associated with CSF and plasma biomarkers. These associations were moderated by APOE ε4 status 👉 buff.ly/2QP8Npb #Alzhimers

Rasmussen et al. report that riociguat, a soluble guanylate cyclase stimulator, induces cranial vasodilation and headache in healthy adults. These findings suggest that guanylate cyclase signalling may play a role in headache pathogenesis 👉 buff.ly/2KVbAxS

Okochi et al., found that female SLC9A6 heterozygotes cause novel Parkinsonian syndrome and tauopathy. This finding was recognised by OMIM and registered as a novel degenerative disease: NDPACS. This review outlines the disease concept of NDPACX 👉 buff.ly/hqzz67A

Garvey et al. report that in a cohort of patients with sensory predominant axonal neuropathies, the presence of chronic cough with either small nerves on ultrasound was associated with the RFC1 gene expansion found in CANVAS 👉 buff.ly/eZ4b9dH

The Early Career Researcher Paper Prize nominations close today! Submissions after 11:59 pm GMT will not be accepted. #ecr #braincommunications Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

Bennett et al. discovered hidden complex repeat expansions in the gene MARCHF6 in two families with rare forms of epilepsy. These expansions were missed by current repeat expansion testing but were revealed by a new analysis approach 👉 buff.ly/OCDxeYs #epilepsy

The Early Career Researcher Paper Prize nominations close in less than 3 days! Submissions after 11:59 pm GMT on the 31st will not be accepted. #ecr #braincommunications Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

Rasgado-Toledo, et al. reported sex-dependent and region-specific effects of combined ethanol exposure and chronic stress on both the rat brain volume and functional networks, affecting its plasticity during neurodevelopment. Read at 👉 buff.ly/EOqLUwf @jalilrt.bsky.social @dangeles.bsky.social

Have you read an outstanding paper published in Brain Communications during 2025? Nominate it for the Early Career Researcher Paper Prize! Less than a week left! 🧠 #ecr Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

We are excited to Introduce the new co-editors in chief Professor David Belin and Professor Tara Spires-Jones! Looking forward to the next chapter in the brain communications family! 🧠 #neuroscience #braincommunications

We have landed on LinkedIn! 🧠 Click the link to get directed to our profile 👉 buff.ly/J7DgSyv #neuroscience #braincommunications

Di Gaetano et al. investigate brain network organization in epilepsy-surgery patients. They show that pathological hubs extend beyond the resection area into its neighbourhood, with substantial patient-specific variability 👉 buff.ly/OyU4adZ #epilepsy

Have you read an outstanding paper published in Brain Communications during 2025? Nominate it for the Early Career Researcher Paper Prize! Nominations open till end of January! 🧠 #ecr Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

De Las Heras et al. report that associations between measures of cortico-spinal excitability and the performance of an upper-limb visuomotor task are diametrically opposed in patients with cortical and subcortical brain lesions 👉 buff.ly/tBN11RA

Howe et al. report that extended formalin fixation of central nervous system tissues hinders gene expression analysis and that common RNA quality metrics do not reliably indicate archived sample quality 👉 buff.ly/XnKIlYd

Mu et al. report that white matter hyperintensities trigger grey matter atrophy. This degeneration propagates through cortico-subcortical structural networks, mediating declines in executive function and processing speed 👉 buff.ly/cJbwzTI

Akbarian et al. report that texture analysis of MRI detects subtle microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia. Observed even when volumetric differences are absent 👉 buff.ly/MLusTEe #dementia

Reilly et al. model brain structural connectivity in Niemann–Pick disease type C using diffusion-weighted MRI. They demonstrate the extent and distribution of connection loss that particularly affects the frontal, temporal and subcortical regions 👉 buff.ly/Knntc2M

Selvadurai et al. report that individuals with spinocerebellar ataxias (SCAs) 2, 3, and 6 have reduced average cognitive screening performance relative to controls 👉 buff.ly/jbfYdso

Have you read an outstanding paper published in Brain Communications during 2025? Nominate it for the Early Career Researcher Paper Prize! Nominations open till end of January! 🧠 #ecr Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

Futamura et al. report that the progression of temporal cognitive dysfunction in Alzheimer’s disease is associated with cerebral blood flow in the bilateral pericallosal regions, as measured by responses to verbal tense and temporal adverb stimuli 👉 buff.ly/QmWTTyk #alzhimers

Novakova et al. report that patients with mild cognitive impairment with Lewy bodies demonstrated impaired comprehension of syntactically complex sentences as compared to healthy controls 👉 buff.ly/EJOTC5N

Lemmik et al. report that genetic deletion of C3ar1 in mice does not result in behavioural or brain changes as measured by structural and functional MRI, despite capturing well known sexually dimorphic and developmental effects in their datasets 👉 buff.ly/aEGusvM @kingscollegelondon.bsky.social

Check out our latest editorial! David Belin and Tara Spires-Jones discuss the importance of fair and constructive peer review while extending thanks to all those who have contributed their expertise in reviewing manuscripts for #braincommunications👉https://buff.ly/pcSwy7p

Soskic et al. investigated the involvement of thalamic subregions in genetic frontotemporal dementia using MRI data. They found thalamic subregions to be affected at presymptomatic and symptomatic stages 👉 buff.ly/1vaxKPm #dementia

Our newest editorial is live! 🧠 Our Guest Editor, Jon Stone, introduces a special collection of articles focusing on functional neurological disorder. Read now 👉 buff.ly/nBe1LxH #braincommunications #neuroscience #neurologicaldisorders

Have you read an outstanding paper published in Brain Communications during 2025? Take note of it for the Early Career Researcher Paper Prize! Nominations are Open! #ecr #paperprize #neuroscience Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

Eisenstein et al. used diffusion MRI to examine central cholinergic white matter pathways in isolated REM sleep behaviour disorder and early PD. Higher pathways integrity is associated with slower cognitive decline 👉 buff.ly/a0pIpJT

MRI shows corticospinal tract (CST) truncation in some amyotrophic lateral sclerosis patients with CST hyperintensity. This disruption appears unrelated to axonal degeneration or edema, but rather may reflect dysfunction in glymphatic drainage 👉 buff.ly/p5wG7AD

Velicky Buecheler et al. have studied accelerated growth or shrinkage of the hippocampus in people with epilepsy and concluded that there is progressive growth of the hippocampus on the side opposite to the epileptic focus 👉 buff.ly/bGljLIr #epilepsy

Yongzhong et al. have studied the risk factors for cerebral echinococcosis in Ganzi and developed a predictive model to help identify high-risk individuals 👉 buff.ly/30Wgltl #echinococcosis

Jakuszyk et al. report that patients with neuromyelitis optica spectrum disorder associated with aquaporin-4 antibodies and a history of transverse myelitis show neurodegeneration in sensory pathways 👉 buff.ly/xGT6Md9