Exercise clearly improves health and longevity, but the molecular signals behind it are hard to measure. This recent study uses multi-platform plasma proteomics to track how proteins change after exercise and with long-term training.

Many drugs for bowel disease fail because they target the wrong cells in the human gut. To address this, researchers built an atlas of ~1 million human intestinal cells and used machine learning to identify the specific gene programs driving disease in each cell type.

You can now fund research or tip content on ResearchHub with a credit card.

In this new preprint, Basecamp Research in collaboration with NVIDIA Health introduce EDEN. EDEN is a foundation AI model that enables AI-Programmable Gene Insertion (aiPGI) by learning how gene insertion works across evolution.

At SciCon 2025, brianarmstrong.bsky.social shared bold predictions on AI’s role in driving future scientific breakthroughs.

Submit a research proposal. Get funded to carry it out. Apply for open Requests for Proposals (RFPs) on ResearchHub.

New Request for Proposals (RFP): AI for Drug Discovery CerebrumDAO has opened a new RFP to fund early-stage research using AI for drug discovery, with a focus on neurodegenerative disorders. 💵 Funding: $5,000 🗓 Deadline: Feb 27, 2026

Most people only associate microglia with brain inflammation and disease. This study shows that cortical microglia also play a role in maintaining sleep-wake balance, by supporting noradrenergic signaling that maintains wakefulness in the healthy brain.

"Motivated reasoning in sustainable consumption: A partisan environmental framing experiment", a Research Plan published in Lifecycle Journal, is under review with @researchhubf.bsky.social. Check it out if you'd like to be part of the evaluation process! www.researchhub.com/paper/105997... @cos.io

"Consciousness and emotions in non-human animals: Are laypeople more or less skeptical than experts?", a Research Plan in @cos.io Lifecycle Journal, is under review at @researchhubf.bsky.social. You can be part of the evlauation process, bounty closes in 3 days: www.researchhub.com/paper/105979...

Lifecycle Journal pub "Reversal or no reversal, that is the question – A conceptual replication of cross-cultural spatial-numerical associations" is under review at @researchhubf.bsky.social 2 days left on the bounty if you want to be part of the evaluation! www.researchhub.com/paper/105961...

We’ve opened 5 new Requests for Proposals to fund research across key areas in biomedicine. Open RFPs: • AI Tools & AI Agents in Biomedical Research — $5k • Genomics & Proteomics — $5k • Aging & Longevity — $10k • Vascular Biology — $10k • Neuroscience — $10k 🗓 Deadline: Feb 15, 2026

Anyone can fund, govern, and support science on ResearchHub with ResearchCoin.

HIV has been incurable for over 40 years. New research suggests this may no longer be the case. Scientists found that rejuvenating CD4 T cells can eliminate hidden HIV reservoirs, pointing toward a possible functional cure without lifelong treatment.

Leading funders discuss where science is headed in the next ten years as it becomes open and AI-driven.

~30% of IVF cycles fail even with healthy embryos. Researchers recreated implantation in the lab using patient-derived uterine organoids and stem cell blastoids. By measuring hormone release and invasion, they showed that IVF success can be predicted by directly testing how the uterus behaves.

Connect with our community supporting ResearchHub in building the future of science, powered by $RSC. Join the ResearchHub community on Discord. 🔗 discord.gg/researchhub

Humans eat small, frequent meals (1-2% body weight). But Burmese pythons can fast for months and then eat their entire body weight in one sitting. By studying what happens after these extreme meals, researchers identify a gut-derived molecule that signals the brain to reduce appetite.

Millions of papers are published every year, yet only a small fraction translate into products and services people actually benefit from.

Scientists share what it’s like to get funded through preregistrations on ResearchHub. ✅ Paid, constructive peer review ✅ Open and faster funding

📹 @itchdoctor shares why negative results and failed trials are some of the most valuable data in science.

ResearchHub Wrapped 2025.

A team of 28 researchers, including @fabiantheis.bsky.social, built the first single-cell map of how human immune cells respond to cytokines. It provides a reference for decoding immune signaling in health and disease and for guiding therapeutic discovery.

We're realigning financial incentives in science with crypto (ResearchCoin).

SciCon 2025 was an invite-only, full day of dialogue on open science, publishing, and research funding. Watch the full day or jump straight to what matters most to you. 👇 youtube.com/playlist?li...

ResearchHub co-founders Brian Armstrong and Patrick Joyce discuss the core problems in science today and and what real progress should look like. Watch the full conversation 👇 youtu.be/is1tzDZWJmY

How could we spotlight groundbreaking work that isn’t getting attention elsewhere?

A full day of discussions and networking left everyone energized and aligned on building better, faster and more open science. Thank you to everyone who joined us for SciCon 2025. See you at the next edition!

SciCon 2025 brought scientists, funders and founders together in one room for a full day of discussions. Here are the highlights from an event that left everyone energized. 1/8

We’re looking forward to a candid conversation with major science funders about how they allocate capital and measure impact. Speakers: • Jordan Dworkin, PhD | Coefficient Giving • Kumar Garg | Renaissance Philanthropy • Bishakha Mona, PhD | Science Philanthropy Alliance

Faster and more transparent science funding isn’t just theoretical, we’ve seen it work. We’re bringing researchers and funders together to discuss practical alternatives to traditional grants.

Can (and should) academia be decentralized? Our panel of experts will assess the feasibility of decentralization in academia and what it would mean for science.

We’re honored to announce Professor John Ioannidis will deliver a keynote at SciCon 2025. Dr. Ioannidis is Stanford professor and one of the most-cited scientists. He has delivered ~700 invited and honorary lectures and is globally recognized as a leading voice in reproducibility and meta-research.

Do you have a question for our founders? Submit it for the Fireside Chat. We’ll ask selected questions live on stage during the Fireside Chat with Brian Armstrong and Patrick Joyce. 🗓️ Deadline: Nov 28, 2025 📩 Submit here: docs.google.com/forms/d/e/1...

SciCon 2025 will kickoff with a Fireside Chat featuring ResearchHub co-founders Brian Armstrong and Patrick Joyce. They will discuss ResearchHub’s vision for enabling faster, more open, incentive-aligned science.

We are convening top leaders in open science, publishing, and research funding for a full day of dialogue and open networking. Explore the speaker lineup below.

Researchers have developed the first 3D human brain-on-a-chip with all major cell types and a working blood-brain barrier. This makes it possible to test whether specific drugs can cross the barrier and work as treatments.

Modern proteins are built from a set of 20 amino acids, but “early Earth” likely had only about 10 of them. Using AI-based protein design tools, researchers show it is possible to build stable, well-folded proteins from just this simpler set.

New research shows that stress biases the hippocampus toward spotting patterns rather than storing detailed memories. This shift helps the brain anticipate what’s coming next, but at the cost of recalling precise details.

Researchers report the first evidence that immune cells from the blood and skull can enter the brain without a clear blood-brain barrier leak while remaining molecularly distinct from microglia. This hints at gentler brain immune therapies compared to irradiation or heavy chemo.

The 3 best-performing peer reviewers on ResearchHub in Q3 2025.

30 days until SciCon 2025. ResearchHub’s 4th annual conference bringing top scientists, founders, and funders together for a full day of discussion and open networking.

A new preprint shows that a common enzyme can “unzip” polyurethane foams (used in furniture and insulation) into its original components to remake fresh foam. If this scales, it points to true closed-loop foam recycling, less landfill, and less need for new petrochemicals.

A new preprint establishes the theoretical foundation for photonic extreme learning machines that compute by propagating light through diffusive media.

What are the highest-potential areas of research that are underfunded today? We asked AI to imagine the answers discussed by researchers on ResearchHub.

Intermittent fasting leads to changes in metabolism, immunity, epigenetics, and the microbiome. This preprint followed 114 women for 6 months, providing molecular evidence behind this popular practice. Iron balance and immune remodeling are key to its health benefits.

$5000 Bioinformatics and Genomics Proposal Spotlight 📅 Sept 25| 🕒 1 PM PDT | 📍 LinkedIn Live You’ll hear 3-min pitches, ask questions, and help decide who gets the $5K grant.

$5000 Bioinformatics and Genomics Proposal Spotlight 📅 Sept 25| 🕒 1 PM PDT | 📍 LinkedIn Live You’ll hear 3-min pitches, ask questions, and help decide who gets the $5K grant.

Our 4th annual conference, SciCon, takes place on December 4, 2025 with the leading minds in science and tech. 🎥 It’s invite-only, with limited seats. But the conversations matter to everyone, so recordings will be shared publicly. Speaker lineup coming soon.

We’ve paid out over $890,000 to peer reviewers. • 10-day avg. turnaround • 9010 reviews completed We’re celebrating #PeerReviewWeek by rethinking incentives in peer review. On ResearchHub, peer review is fast, open, and paid.