Welcome!

#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…

Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...

Fierce Biotech story about the "priorities" memo www.fiercebiotech.com/research/nih... 1/4

Some say you either have "it" or you don't, and that creativity cannot be learned, but that really misses the point. Creativity is lost in the wrong environment. We need to recognize the "night science" aspect of our work and that we need to nurture it in our training. www.nature.com/articles/d41...

New Notice about No-Cost Extensions... grants.nih.gov/grants/guide...

Check out our new preprint on a novel neuro-immune niche that underpins touch in the cornea

Beautiful spatial transcriptomics of developing meninges and meningiomas. Hints into the origins of meningiomas arising from the dural border 🤩🧐

You don’t see #VisionResearch. But it sees you. Most of us don’t think about vision research. But millions live every day with the impact of it—when it’s there, and when it’s not. Vision research changes lives. bit.ly/3GXVIaZ #SeeWhatMatters #FundFederalVisionResearch

Previously unknown prenatally derived macrophage is uniquely involved in lipid metabolism and vascular maintenance and is decreased and dysfunctional in age-related macular degeneration @jem.org rupress.org/jem/article/...

Fortmann, Grant et al. show that prenatally derived #macrophages support choroidal health and decline in age-related #maculardegeneration rupress.org/jem/article/... 📘 In our Clinical #Immunology Collection: rupress.org/jem/collecti... #FOCIS2025

Wow.. this cover!! 😍 @jem.org looking jazzy this month! Take a look at the July issue here 👉 rupress.org/jem/issue/22...

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.

Organoids don’t have immune systems

Excited to see this collection out! Thank you to all the authors and reviewers who contributed!

Assistant prof opening for Immunology umc.edu/som/Departme...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now [email protected] #macrophages

Reimbursement

Sejiro Littleton takes home the coveted #GliaCamp best talk award 🥇. “Neuroimmune niche underpins touch.” He’s on the market for a postdoc position, for those who are asking! @MosemanLab @FilianoLab and students organized another wonderful camp ⛺️. @LongJun_Wu killer keynote@ - who can ask for more

More great content from @preprintclub.bsky.social @epelmanlab.bsky.social. This @biorxiv-immuno.bsky.social preprint from Liu et al. reports that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure.

Thank you @natrevimmunol.bsky.social and Preprint Club, University of Toronto, Alex Lac & ⁦‪Slava Epelman‬⁩ for reviewing our preprint! www.nature.com/articles/s41...

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Res…

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

Another Orwellial this morning But with some good news...

Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis https://www.biorxiv.org/content/10.1101/2025.01.25.634888v1

Our new #immunology collection highlights recent studies on barrier immunity, microbiota, molecular immunology, neuroimmunology, and stem cells and regeneration. Explore new research from JEM to accompany the @midwinter-immun.bsky.social Conference! 📚👉 https://buff.ly/4geAP6W

🔥Today's new episode of the Night Science Podcast is super cool: A hypothesis is a liability! We talk about the interplay between hypothesis-driven and exploratory research, and discuss the insights of previous guests of the podcast. I'm really curious to know what you'll think!

Haha!

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)

likewise, happy to have contributed to the comprehensive update on this important topic

Lots of things should scale with GDP. In 1963, we spend 2.5% of GDP on science and research in America. In 2024, we are spending 0.5% GPD on science and research in America.

Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Looking forward to seeing how CAFE projected our spectral flow dataset from 2021, "Mucosal-associated invariant T cell responses differ by sex in COVID-19: Med www.cell.com/med/fulltext... www.biorxiv.org/content/10.1...

Spatial Proteomics is the Method of the Year 2024!

Hot off the press. We observed elevated levels of G-CSF in AMD human donor RPE-Choroid tissue and identified c-reactive protein as an AMD associated stressor responsible for increased G-CSF levels. @choroidlab.bsky.social @adnankhan.bsky.social @stemcellseh.bsky.social.

Macrophages excite muscle spindles with glutamate to bolster locomotion www.nature.com/articles/s41...

As teams get larger for many life sciences projects, it is important to recognise a range of contributions. When I spoke with Cori Bargmann for the EMBO podcast, she highlighted how in physics, it is the team leader's obligation to make sure credit is distributed fairly.

A lesson I had reinforced by Mike that has benefitted me TREMENDOUSLY in my future endeavors is: When you are surrounded by smart and capable people, guide them, but empower them and let them show their stuff. They will do things better than you could and will surprise you with new ideas. 22/n

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact. A must read for PhD students: Problem choice and decision trees in science and engineering. pubmed.ncbi.nlm.nih.gov/38608651/

The goal is not to have a zero risk project; those are generally not worth working on. People with a good relationship with risk are definitely not avoiding it. They are super honest about it and they basically make it their goal to slowly chip away at it. nightscience.buzzsprout.com/1744020/epis...

I haz two: go.bsky.app/3EWSGiv

"Culturing microglia induces rapidly increased growth, protein content, and inflammatory protein expression. These changes are restored by engrafting in vitro cells into the brain, with xenografted human embryonic stem cell (hESC)-derived microglia closely resembling microglia from the human brain."

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. www.nature.com/articles/d41...

Following a question from @dabiophysicist.bsky.social , I want to share some analyses and thoughts about indirect cost rates. This follows on from a #datahound post about indirect costs some years ago. datahound.scientopia.org/2014/05/10/i... Here goes, starting with some background... 1/n

Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns www.fiercebiotech.com/research/rep...

I'm an immunologist who is trying to understand why not everyone recovers from an infection, and why the infection-associated chronic illnesses skew female. I run a lab @mitdeptofbe.bsky.social, the clinical study MIT MAESTRO, and am building a mouse model of #chronicLyme. Will pin threads here.