Truly beautiful myelin imaging Bobby, Congrats!!

At the myelin-axon interface, axon-glial signaling, paranodal architecture, and β-amyloid aggregation are altered in Alzheimer's disease, implicating myelin-axon disruption in disease progression @jgrutzendler.bsky.social @yifeicai.bsky.social www.nature.com/articles/s41...

very appreciative of this collaboration!! @reimand.bsky.social

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease. 🔗 Read here: www.nature.com/articles/s43...

Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers engineering.stanford.edu/news/future-...

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵

likewise, happy to have contributed to the comprehensive update on this important topic

I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.

What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇 www.science.org/doi/full/10....

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

elegant paper from Robert Hill’s lab www.biorxiv.org/content/10.1...

interesting paper www.nature.com/articles/s41...