Somatic mutational signatures describe where mutations come from 🧬. But do they shape how proteins function? In our new preprint, we show that mutational processes can systematically rewire cellular signaling networks by altering short linear motifs (SLiMs). Preprint: www.biorxiv.org/content/10.6...

First I'm hearing of DOPRA, love it! "Denial of peer review attack" concept by @lpachter.bsky.social

New preprint from the lab: medrxiv.org/cgi/content/... . HNY2026!

Finding the right balance of persistence and letting-it-go

Graduate school interview season is approaching. After ~12 years of interviewing PhD and MD/PhD applicants, I’ve noticed some common interview mistakes that hold otherwise strong candidates back... #GraduateSchool #PhDLife #MDPhD #GradSchoolTips #AcademicBluesky 👇

Merry Christmas, genetic interaction nerds: www.biorxiv.org/content/10.6...

🧬 Protein that unties tangled DNA linked to hotspots of cancer mutations: Research from @reimand.bsky.social and his collaborators associated a chemotherapy-related cellular process with genetic mutations and used it to identify novel cancer driver alterations. https://bit.ly/4iMcV5B

⚠️New study: we mapped DNA-binding of topoisomerase TOP2B in cancer, uncovering surprising hotspots of DNA damage. TOP2B, normally essential for DNA stress relief, can act as a double-edged sword. co-led by @LiisUuskula @ChristianLee, out now @natcomms.nature.com www.nature.com/articles/s41... [1/7]

Better DNA repair machinery protects one of the largest mammals from cancer: www.nature.com/articles/s41... 🐋

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

made my first meme to celebrate the never-boring pathway to publication. #PIlyfe #openaccess

Excited to see this study led by Nick Min & Xi Huang published this week and grateful for a decade of collaborations : www.nature.com/articles/s41...

Congrats to our PhD student Masroor Bayati for his first-author publication out this week. We developed a computational method to map synergistic interactions in omics datasets and studied prognostic signals of co-occurring cancer driver alterations and TME features. aacrjournals.org/mcr/article/...

Hey everybody! @drjuliawester.bsky.social and I have a new paper! We surveyed over 800 scientists, science communicators, and science educators who use social media. Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑 doi.org/10.1093/icb/...

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ

We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95

meticulously delve into intricate this

Another great collaboration with Carolina Nor & Michael Taylor: Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. @abahcheli.bsky.social led our omics integration via pathway analyses. @cp-devcell.bsky.social www.cell.com/developmenta...

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal. We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers 🧪 #AcademicSky www.nature.com/articles/d41...

Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...

very happy to have contributed to this collaboration with the Taylor lab - with integrative pathway analyses & rich network visualizations led by our PhD student @abahcheli.bsky.social

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is” https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

George R. R. Martin on @biorxiv-evobio.bsky.social!

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer - using a spit test www.nejm.org/doi/full/10....

enjoyed this thought-provoking essay: The end of the genetic paradigm of cancer journals.plos.org/plosbiology/...

We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!