We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

@lucksmith.bsky.social @nelson-lau-lab.bsky.social blast from the past (at least for me).

And with this, only one team can still win the #6NationsGrandSlam. Great game #Scotland. 🏉

WTF? The game is 30min in and AFAIK, there are no controversy with the ref. Why are these websites creating such BS (and Google promoting them)? #ScoEng (BTW, great game so far 😂)

I recently got myself a bird cam to observe cute birds in my yard. The last 4 observations:

« The art of the footnote » @matthewcobb.bsky.social . Great book, thanks a lot for writing it!

I get why all NIH grants are under a passcode for reviewers, but please, can we make it such that the text in the PDF can be copied? So frustrating to when one wants to cite a sentence in the review, for instance... Anybody got a fix for that?

LOL. I can’t think of a better way to make sure they get loudly booed! Italian fans, please don’t disappoint

Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases www.nature.com/articles/s41... "We analyzed genetic association data from ~2.9 million genomes..." 🤯🤯🤯

#NYC5amClub wishes you all a good #6Nations Tournament and #AllezLesBleus!

Oh, no! Sunday morning cold plunge "Freeze Against Cancer" by Swim Across America is postponed! If anybody wants to join us on March 15, here is the link: www.swimacrossamerica.org/site/TR/Pool...

The "Friends Don't Let Friends Make Bad Graphs" list is great... BUT I STRONGLY disagree with the suggestion to use log scaled axis on barplots. (the absolute worse being "stacked barplots on logscale") Just don't use barplots if the values are on different orders of magnitude. Who's with me?

Now online! Hallmarks of cancer—Then and now, and beyond

Tom Morello in Minneapolis last night. 🤩 KILLING IN THE NAME

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

This is a paper I am super proud of, long in the making, packed with important concepts. It was old data and n=1 (most stronge claims backed with patients), metastatic clones are endowed with plasticity to adapt to multiple organ environments.

“Monet in Venise” at @brooklynmuseum.org. Inside and outside!

Wisdom graffiti

Any bioinformatics friends out there have a huge load of AI code credits & want to try smth crazy (but amazing if it works)? What if we ask Claude to port STAR to Rust? Current development and maintenance on this central tool has largely stalled, but I think a lang change would reinvigorate it!

Clinical genetic variation across Hispanic populations in the Mexican Biobank www.nature.com/articles/s41...

A transposase-derived gene required for human brain development | Science Advances www.science.org/doi/10.1126/...

Author's contribution: removed all double-space in several versions of the manuscript.

do they realize proteins come from mRNA?

"Illumina Appoints Former NHGRI Director Eric Green as Chief Medical Officer" www.genomeweb.com/sequencing/i...

EcDNA-borne structural variants drive oncogenic fusion transcript amplification www.cell.com/cell/fulltex...

My first day of 2026 will last 38 hours. It should feel pretty weird, I guess.

Where your email did (not) find me.

TIL Rosalind Franklin lived in Paris in 1947-49. A plaque was recently installed on her building at 6 Rue Garancière, Paris VI

Genomic Flexibility Through Extrachromosomal Amplifications: A Leishmania Survival Strategy https://www.biorxiv.org/content/10.64898/2025.12.13.692850v1

I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.

Last night at the local iMax. Kubrick remains the best!

Transcriptomic Plasticity is a Hallmark of Metastatic Pancreatic Cancer, by Christine Iacobuzio-Donahue, @danapeer.bsky.social et al. pubmed.ncbi.nlm.nih.gov/41379552/ introduces a new single-cell method named PICASSO: Phylogenetic Inference of CNA in Single-cell RNA [...] github.com/dpeerlab/pic...

@greally.bsky.social Do yourself a favor and mark your calendar for Feb 5 afternoon. You don't want to be stuck in a meeting that day!

Zena Cardman, currently at the space station, was a poetry double major at UNC. She was chosen as an astronaut partly due to her creative side which would help inspire others to enjoy space. Yes, her other degree was science, but the poetry is what got her "hired".

Looking more and more like his puppet on the French "Guignols de l'Info"

Out now in @natgenet.nature.com, our Comment analyzing uses of the Human Genome Diversity Project (HGDP), a controversial dataset in human genomics research. A 🧵 rdcu.be/eRu65 1/

"Concerns about the legitimacy and integrity of Nucleus Genomics", by X account @sichuan_mala totalhealthoptimization.com/2025/11/21/c...

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

Who you gonna call? Which protein do you want to talk to? Can we talk to noncoding RNA too or will they be nonverbal?

The NHGRI is finally ready to appoint a new director. Deadline = 1 week from today. hr.nih.gov/careers/open...

#Bataclan #13Nov2015

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Look what just arrived @greally.bsky.social

James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97 www.nytimes.com/2025/11/07/s... Complicated legacy obviously, but a towering figure for our field.

Dat you, @stephenturner.us ?

GSholarLens is « not affiliated with Google Scholar » project.iith.ac.in/sharmaglab/g...

Hi everyone! I'm working with Visium spatial transcriptomics data deconvolved with cell2location. Need advice on calculating gene signature scores (e.g., acidosis) from deconvolved expression layers. 🧬🖥️ #spatialtranscriptomics

Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ? Ce stage pourrait vous convenir. www.ebi.ac.uk/about/jobs/i...

trying to find a preprint, stumbled across this concurrent work published just a few weeks ago from an unrelated lab which is also based in new york. weird. www.cell.com/current-biol...