Jack Szostak "All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."

Maybe it takes them forever to get out of the capsule because they actually look like this:

Where are the wild speculations on what will be announced next week? is it more cells, more precise spatial measurement, or something entirely different?

🚨🚨🚨 AACR abstracts just hit Google Scholar!🚨🚨🚨

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

Kendall Square experience: 2 Bluesky royals in the breakfast room. I hope they'll have a good day here today!

🇫🇷-🇧🇷in ⚽️. I know it’s a friendly but that will always be meaningful for my whole generation #iWillSurvive #BRAFRA

Excited to share our new preprint on gnomAD v4! We present the full analysis of 730,947 exomes — new constraint metrics, improved LoF annotation (LOFTEE-2), LLM-based literature curation, and a unified framework for gene discovery and rare disease diagnosis. www.medrxiv.org/content/10.6...

Congratulations to @tuuliel.bsky.social PhD, Senior Associate Faculty Member at the New York Genome Center, on receiving a prestigious award from the @eshg.bsky.social! Read more about this well-deserved recognition: www.nygenome.org/news-events/...

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

Despite the obvious superiority of fresh-frozen material for genomics, many samples are still stored in FFPE and remain challenging to characterize with Whole-genome sequencing. But here comes our solution:

hey @lemonde.fr je vous offre une capture d’écran pour votre prochain article sur la baisse du niveau scolaire

Polar Plunge this morning with Swin Across America! (rescheduled from early February, because the Sound was frozen back then!)

Despite the obvious superiority of fresh-frozen material for genomics, many samples are still stored in FFPE and remain challenging to characterize with Whole-genome sequencing. But here comes our solution:

An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding https://www.biorxiv.org/content/10.64898/2026.03.10.710815v1

Fast and accurate resolution of ecDNA sequence using Cycle-Extractor https://www.biorxiv.org/content/10.64898/2026.03.10.710955v1

Global Re-Analysis Confirms Absence of the DNAJB1::PRKACA Fusion in Hepatoblastoma. www.mdpi.com/2072-6694/18... Comment on Fleifil et al. ("DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways") www.mdpi.com/2072-6694/17...

And even wilder Italy!!! Grazie Mille!!! Wonderful victory!

Wild wild game by Scotland! Totally amazing. Bravo! #rugby #VINations

Flying back from London, after a wonderful @cancergrand.bsky.social Summit! And very proud that after all those years, I finally got drawn by @atjcagan.bsky.social!

📰 News announcement! www.cancergrandchallenges.org/new-teams-an... We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch. Find out more about the teams and their challenges.

March is #Endometriosis Awareness Month, and this Editorial by Alex Tosun (@atosun.bsky.social) discusses why greater awareness, education, funding and research for this systemic condition is imperative to redefining pain, equity, and investment in women’s health 🧪🌻 #Medsky plos.io/4slvscE

Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...

Entirely unrelated but I’m excited to be in London next week!

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. #BioNTech www.nature.com/articles/s41...

Not sure I’ll find a lot of people to talk #rugby next week in London… what a game, Ireland! 🏉 #6nations

"Tempus AI Sued For Breach of Genetic Information Privacy Act" 🤔 www.genomeweb.com/cancer/tempu...

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

@lucksmith.bsky.social @nelson-lau-lab.bsky.social blast from the past (at least for me).

And with this, only one team can still win the #6NationsGrandSlam. Great game #Scotland. 🏉

WTF? The game is 30min in and AFAIK, there are no controversy with the ref. Why are these websites creating such BS (and Google promoting them)? #ScoEng (BTW, great game so far 😂)

I recently got myself a bird cam to observe cute birds in my yard. The last 4 observations:

« The art of the footnote » @matthewcobb.bsky.social . Great book, thanks a lot for writing it!

I get why all NIH grants are under a passcode for reviewers, but please, can we make it such that the text in the PDF can be copied? So frustrating to when one wants to cite a sentence in the review, for instance... Anybody got a fix for that?

LOL. I can’t think of a better way to make sure they get loudly booed! Italian fans, please don’t disappoint

Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases www.nature.com/articles/s41... "We analyzed genetic association data from ~2.9 million genomes..." 🤯🤯🤯

#NYC5amClub wishes you all a good #6Nations Tournament and #AllezLesBleus!

Oh, no! Sunday morning cold plunge "Freeze Against Cancer" by Swim Across America is postponed! If anybody wants to join us on March 15, here is the link: www.swimacrossamerica.org/site/TR/Pool...

The "Friends Don't Let Friends Make Bad Graphs" list is great... BUT I STRONGLY disagree with the suggestion to use log scaled axis on barplots. (the absolute worse being "stacked barplots on logscale") Just don't use barplots if the values are on different orders of magnitude. Who's with me?

Now online! Hallmarks of cancer—Then and now, and beyond

Tom Morello in Minneapolis last night. 🤩 KILLING IN THE NAME

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

This is a paper I am super proud of, long in the making, packed with important concepts. It was old data and n=1 (most stronge claims backed with patients), metastatic clones are endowed with plasticity to adapt to multiple organ environments.

“Monet in Venise” at @brooklynmuseum.org. Inside and outside!

Wisdom graffiti

Any bioinformatics friends out there have a huge load of AI code credits & want to try smth crazy (but amazing if it works)? What if we ask Claude to port STAR to Rust? Current development and maintenance on this central tool has largely stalled, but I think a lang change would reinvigorate it!

Clinical genetic variation across Hispanic populations in the Mexican Biobank www.nature.com/articles/s41...

A transposase-derived gene required for human brain development | Science Advances www.science.org/doi/10.1126/...

Author's contribution: removed all double-space in several versions of the manuscript.