The NHGRI is finally ready to appoint a new director. Deadline = 1 week from today. hr.nih.gov/careers/open...

#Bataclan #13Nov2015

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Look what just arrived @greally.bsky.social

James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97 www.nytimes.com/2025/11/07/s... Complicated legacy obviously, but a towering figure for our field.

Dat you, @stephenturner.us ?

GSholarLens is « not affiliated with Google Scholar » project.iith.ac.in/sharmaglab/g...

Hi everyone! I'm working with Visium spatial transcriptomics data deconvolved with cell2location. Need advice on calculating gene signature scores (e.g., acidosis) from deconvolved expression layers. 🧬🖥️ #spatialtranscriptomics

Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ? Ce stage pourrait vous convenir. www.ebi.ac.uk/about/jobs/i...

trying to find a preprint, stumbled across this concurrent work published just a few weeks ago from an unrelated lab which is also based in new york. weird. www.cell.com/current-biol...

Transcriptional interferences ensure one olfactory receptor per ant neuron www.nature.com/articles/s41... Caviar for RNA-Seq nerds! Check this out

We investigated Constellation from Illumina @bcmhgsc.bsky.social for rare disease cases @gregor-research.bsky.social from @bcmhouston.bsky.social. We tested HG002-4 & sequenced 21 families. We could detangle complex SV & other interesting findings described here: www.medrxiv.org/content/10.1...

#NoKings. Or else? 01-21-1793 [ref needed?]

Finally saw a job offer that's compliant with New York state laws, but in a pretty useless way: Pay Range: $0.00 - $10,000,000.00

Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic www.nature.com/articles/s41... (read free: rdcu.be/eLny0) github.com/google/deeps...

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. www.biorxiv.org/content/10.1...

9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!

Still awesome. And here is my new favorite sequencing machine:

I found a doctor to get a second opinion for my dad 6000km away and it let to a dramatic improvement in the health condition that was plaguing his (and my mother's) life. Hard to tell if it would have happened without Twitter.

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

« I drive a Lambo and publish in Nature (Publishing Group) »

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Pretty bold to call a startup "Soufflé Therapeutics". I am not saying we're in a bubble, but as we say in the French "c'est gonflé" www.souffletx.com endpoints.news/souffle-ther...

One more Nobel for Google? Michel Devoret is « is the Chief Scientist at Google Quantum AI » (en.m.wikipedia.org/wiki/Michel_...)

Chaplin was spot on in 1940: youtu.be/isLNLpxpndA?...

Friday night Tennis Grand Challenge with @andreaventura.bsky.social! @cancergrand.bsky.social Team SAMBAI vs Team eDyNAmiC! Lots of fun!

New York 1951: "Where do the Central Park ducks go in winter?" New York 2025: "Where do the luxury black cars go when the UN General Assembly is over?"

That was awesome

colorSV: Long-range Somatic Structural Variation Calling from Matched Tumor-normal Co-assembly Graphs. #SomaticStructuralVariants #SV #CoassemblyGraphs #Bioinformatics #Genomics #GenomicsProteomicsBioinformatics academic.oup.com/gpb/advance-...

Steve Silberman is not here to shout it — so it’s up to all of us. Vaccines don’t cause autism. Neither does Tylenol. (I mean seriously WTF?!?!) The “epidemic” of autism is the result of increased testing, broader definitions, and raised awareness. LOUDER.

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

First day of fall, feeling colder in the house, put on my hoodie and found the car keys I looked for all summer (and blame my daughter for losing). I am pretty sure I'll hear about that one for many years...

“Comprehensive benchmarking of somatic structural variant detection at ultra-low allele fractions” by @smahtnetwrk.bsky.social, led by @sedlazeck.bsky.social www.biorxiv.org/content/10.1...

The Non-Coding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions aacrjournals.org/cancerrescom...

"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance" Congrats Vincent Colot and team! www.science.org/doi/10.1126/...

We're writing a piece involving the "University of Paris-Saclay in Orsay", can you find a nice illustration, quick quick... www.nature.com/articles/d41...

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

Anyone? Bueller? The best rough estimates I can find so far are in the low Exabyte range.

Great for the @newyorker.com to do a whole piece dedicated to their famous fact-checking department www.newyorker.com/magazine/202... Too bad a couple of pages later, they got the name of a Sotheby's employee spelled incorrectly 😂 www.newyorker.com/magazine/202... www.sothebys.com/en/about/tea...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

I started in @lucksmith.bsky.social's lab exactly 17 years ago, my daughter welcomed his as a Senior in the same High School this morning, and I am proud to count him and his family as friends, neighbors and mentors!

Interesting preprint by the @owkin.bsky.social team: OwkinZero: Accelerating Biological Discovery with AI arxiv.org/abs/2508.16315

Mutational landscape of triple-negative breast cancer in African American women www.nature.com/articles/s41...

🎉 scverse conference 2025 Registration & Call for Abstracts NOW OPEN! 🎉 We're excited to announce that registration and the call for abstracts are officially open for the scverse Conference 2025! Details in thread! 🧵 1/3

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

The videos and slides from the @cshlmeetings.bsky.social "Cancer Genetics. History & Consequences" organized in March 2025 are now available at library.cshl.edu/Meetings/Can...

The videos and slides from the @cshlmeetings.bsky.social "Cancer Genetics. History & Consequences" organized in March 2025 are now available at library.cshl.edu/Meetings/Can...

#science 🧪

This Parisian in NYC really loved the @newyorker.com “Critics at Large” podcast episode on “Americans in Paris” with the brilliant Alexandra Schwartz and Lauren Collins. Such a delight! podcasts.apple.com/us/podcast/c...