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Single Cell Genomics Day: A (Virtual) Practical Workshop. June 12, 2026, organized by @nygenome.org's Rahul Satija Free, livestreamed, no registration.

[fr] Je pense que ce traducteur de l’anglais (Américain) n’a jamais foutu les pieds dans un MacDo (in Le Maître des Illusions (The Secret History). Donna Tart 1993)

A multi-agent system for automating scientific discovery www.nature.com/articles/s41... An AI system to help scientists write expert-level empirical software www.nature.com/articles/s41... Accelerating scientific discovery with Co-Scientist www.nature.com/articles/s41...

Accelerating scientific discovery with Co-Scientist: www.nature.com/articles/s41... rdcu.be/fjE3k

I don’t know the details of that particular story and it sounds amazing. But WHY are we giving all the credits to « AI » when it’s the results of a ton of people’s great work (to set up the program, run sequencing and bioinformatics analyses, multi-disciplinary medical boards, etc)?

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

⚠️Preprint alert⚠️: we set up Polyethnic-1000 at @nygenome.org to study the molecular basis of cancer disparities. One striking example is endometrial cancer, with much higher mortality in patients of African ancestry.

[fr] SciencesPo, ENS, HEC

Front row seat at Carnegie Hall with @grimmrad.bsky.social

of many projects Craig Venter led, of personal significance was the fly genome, a unique and i think unexpected collaboration of his company Celera Genomics and the BDGP, led by my pd advisor Gerry Rubin. the power of a shotgun sequenced metazoan, benchmarked to a physical map, transformed genomics.

J. Craig Venter, a scientist and entrepreneur who decoded the human genome, has died at 79.

Our new paper, led by @renatopolimanti.bsky.social and I, and published today in Nature Genetics, is the largest multi-ancestry GWAS of endometriosis to date including 1.4 million women, 105,869 cases, six global ancestry groups. Previous studies were almost exclusively European.

Getting “us” to Mars.

I have an adult kid…

When Einstein developed general relativity the closest thing to a practical application that could even be imagined at the time was a slightly more precise description of where to look for the planet Mercury in the sky, and yet now we’d all be literally lost without it. Anyway: fund basic research.

For me, it was the fact that I misred and misunderstood this ad...

Very interesting read. www.asimov.press/p/bioinforma... (Thanks to @torstenseemann.bsky.social for sharing over on the #ABACBS slack)

📖 My book BEYOND INHERITANCE is out today. tinyurl.com/5yjsr97n This journey started with a fact I couldn’t ignore: Even in otherwise healthy adults, mutant cells can appear in the blood—quietly doubling the risk of heart disease and stroke.

Deep QC should run on every sequencing dataset. In a new post, Fulcrum co-founder @tfenne.bsky.social explains why he built Riker, a modern successor to Picard designed to make rich sequencing QC fast enough to run every time. Blog: shorturl.at/oUTXk Repo: github.com/fulcrumgenom...

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Think about it next time you fill your disclosure of conflict of interests for papers/grants/talks etc.

Here it is: Atera: « High throughput. Whole transcriptome. Single cell sensitivity. » pages.10xgenomics.com/wbr-2026-02-... Thoughts?

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

'Our results support the hypothesis that somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease.' www.nature.com/articles/s41...

THE HUMAN MOSAIC Why to live is to mutate. By Jerome Groopman. www.newyorker.com/magazine/202... A review of Roxanne Khamsi « Beyond Inheritance » www.penguinrandomhouse.com/books/711682...

Jack Szostak "All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."

Maybe it takes them forever to get out of the capsule because they actually look like this:

Where are the wild speculations on what will be announced next week? is it more cells, more precise spatial measurement, or something entirely different?

🚨🚨🚨 AACR abstracts just hit Google Scholar!🚨🚨🚨

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

Kendall Square experience: 2 Bluesky royals in the breakfast room. I hope they'll have a good day here today!

🇫🇷-🇧🇷in ⚽️. I know it’s a friendly but that will always be meaningful for my whole generation #iWillSurvive #BRAFRA

Excited to share our new preprint on gnomAD v4! We present the full analysis of 730,947 exomes — new constraint metrics, improved LoF annotation (LOFTEE-2), LLM-based literature curation, and a unified framework for gene discovery and rare disease diagnosis. www.medrxiv.org/content/10.6...

Congratulations to @tuuliel.bsky.social PhD, Senior Associate Faculty Member at the New York Genome Center, on receiving a prestigious award from the @eshg.bsky.social! Read more about this well-deserved recognition: www.nygenome.org/news-events/...

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

Despite the obvious superiority of fresh-frozen material for genomics, many samples are still stored in FFPE and remain challenging to characterize with Whole-genome sequencing. But here comes our solution:

hey @lemonde.fr je vous offre une capture d’écran pour votre prochain article sur la baisse du niveau scolaire

Polar Plunge this morning with Swin Across America! (rescheduled from early February, because the Sound was frozen back then!)

Despite the obvious superiority of fresh-frozen material for genomics, many samples are still stored in FFPE and remain challenging to characterize with Whole-genome sequencing. But here comes our solution:

An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding https://www.biorxiv.org/content/10.64898/2026.03.10.710815v1

Fast and accurate resolution of ecDNA sequence using Cycle-Extractor https://www.biorxiv.org/content/10.64898/2026.03.10.710955v1

Global Re-Analysis Confirms Absence of the DNAJB1::PRKACA Fusion in Hepatoblastoma. www.mdpi.com/2072-6694/18... Comment on Fleifil et al. ("DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways") www.mdpi.com/2072-6694/17...

And even wilder Italy!!! Grazie Mille!!! Wonderful victory!

Wild wild game by Scotland! Totally amazing. Bravo! #rugby #VINations

Flying back from London, after a wonderful @cancergrand.bsky.social Summit! And very proud that after all those years, I finally got drawn by @atjcagan.bsky.social!

📰 News announcement! www.cancergrandchallenges.org/new-teams-an... We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch. Find out more about the teams and their challenges.

March is #Endometriosis Awareness Month, and this Editorial by Alex Tosun (@atosun.bsky.social) discusses why greater awareness, education, funding and research for this systemic condition is imperative to redefining pain, equity, and investment in women’s health 🧪🌻 #Medsky plos.io/4slvscE

Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...