Multivariate genome-wide association study of suicidal behaviors in >1.7 million individuals of diverse population descents https://www.medrxiv.org/content/10.64898/2025.12.15.25342298v1

With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG

What we discovered during the #ASHG25 Featured Plenary Abstract Session III—the complexity of the human genome can be studied through many innovative approaches/tools, and there’s a need for more globally representative genomes and cohorts. #ASHG

Day three of #ASHG25 is complete! ✔️ For today’s highlights we: 💡Soaked up insights from today’s scientific sessions 🏅Celebrated the excellence of our outstanding awardees 🔗Connected & collaborated with fellow attendees See you tomorrow for day four!

“We must keep going with this ability to sample genomes, not just in the convenient places we started out with.” - former Director of the National Institutes of Health, Francis Collins, MD, PhD, during his recognition speech at #ASHG25

Thanks to @geneticssociety.bsky.social, if you are coming early to #ASHG25 you can show your badge at the Boston Museum of Science and get in free! Stop by for your badge first and then head over if you are not going to any of the workshops, before Sarah Tishkoff’s presidential address at 4:30pm.

⏰ TODAY at NOON ET, we’re giving you all the details you'll need to make your #ASHG25 experience in Boston one to beat! Join our webinar for: ✅Pro tips on navigating the event ✅Live Q&A ✅Must-have resources Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG

Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...

🚨It’s now or never! Today’s your last chance to save on the event bringing human genetics and genomics professionals together. Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25... #ASHG

"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com) Link: www.nature.com/articles/s41...

‪Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:

‪Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:

Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti... Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.

🚨Our new study, led by Jun He, is out on ‪@alzdemjournals.bsky.social‬‬! Leveraging @ukbiobank.bsky.social and #AllofUs, we uncovered sex-specific effects of socioeconomic and cognitive factors on the assessment of #alzheimers family history. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Submitting an abstract for the first time or needing a refresher on the process? We've got you covered! When you submit an abstract to #ASHG25, you'll go from preparation to notification in just 6 steps. 📌Save this post for later 🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG

That's right – registration is open for #ASHG25!🧬Follow the link below to secure your spot and join us in Boston, MA for five days of scientific and industry excellence. We can't wait to see you there! 🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics

Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis 👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social 

Join "Mendelian Randomization for Causal Inference: Genetically Informed Causal Inference Through #MendelianRandomization and Other Approaches" with @renatopolimanti.bsky.social on April 9-11! Discover how genetic variation can uncover #causal relationships in large-scale datasets.

I love this photo that @melissabender.bsky.social captured of me at the #standupforscience rally yesterday in NYC. I wonder if I could make this my official faculty photo lol @jackiantonovich.bsky.social @kimberlywheiman.bsky.social @archaeoscape.bsky.social @sarahruncie.bsky.social

Transgenic mice are widely used in cancer research to study tumor development, genetic mutations, and potential treatments. TRANSGENIC

Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses https://www.medrxiv.org/content/10.1101/2025.02.28.25323099v1

🔥Some Predictions about the NIH situation, NIH budget cuts 🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14. 🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)

🚨PA colleagues: "Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania." "If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC Get out your Other Support and share that info!

Women with endometriosis are more likely to experience childhood and adulthood traumas, independently of genetic predisposition. by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky 📖 read the article:

Genetically defined population descriptors can reduce inaccuracies in research, but should they completely replace more conventional descriptors in the [email protected] latest article provides perspectives on this important genomic medicine topic: www.cell.com/ajhg/fulltex... #ASHG

So happy to see this article out now and have gotten to contribute to it! Please go give it a read!

I am so excited to share our new study published in @jama.com Psychiatry! Including >240,000 women (>8,000 patients with endometriosis), we found that patients reported more childhood and adulthood traumatic experiences. @renatopolimanti.bsky.social @lokhammer.bsky.social

New findings indicate a significant link between traumatic experiences and endometriosis, suggesting trauma may influence the disease's development independently of genetic predisposition. doi.org/g834rn

Happy to share the preprint of our GWAS of DSM-defined nicotine dependence! Thanks to all my coauthors for their hard work on this, especially co-first author Dongbing Lai & my fellow PGC SUD analysts for their many helpful suggestions.

Also joining our roster of courses is “Mendelian Randomization for Causal Inference” taught by @renatopolimanti.bsky.social. Explore the fundamental principles of genetically informed #causalinference analyses in this hands-on seminar! bit.ly/40UcUoO

⏳The deadline is just over 2 weeks away! Propose bold ideas for #ASHG25 Featured Symposium and Interactive Workshops! ✅ Share diverse perspectives ✅ Highlight innovative topics ✅ Inspire the #humangenetics community Don’t wait—submit today 🔗https://www.ashg.org/meetings/2025meeting/present/ #ASHG

Looking for more great content on #statistics, coding, and related topics? Follow our expert instructors, many of whom are on Bluesky! Check out our new Starter Pack for the list.

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

Don't miss our new episode w/ @renatopolimanti.bsky.social, a human geneticist who identified 100+ genes associated w/ anxiety! He discussed how he got his start in #science, overcoming the toughest period of his career, life outside the lab, & more. 🧬 www.peoplebehindthescience.com/dr-renato-po...

If you are into science podcasts and #genetics, I highly recommend this episode! @renatopolimanti.bsky.social is doing some really cool research, and he gives a candid, down-to-earth look into his life and career as a scientist.

Really enjoyed talking with @phdmarie.bsky.social about the work my group is doing and my own experience as a scientist! Thanks again for the invite!

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

So excited that this publication is finally out in the world. Congratulations @alussier.bsky.social & the whole team on this formidable accomplishment. I’m so proud of you!

@renatopolimanti.bsky.social in conversation w/ @ceciletamura.bsky.social at the Quantum Photonics Club www.clubhouse.com/invite/0dvuR...

Updated #PolimanTEAM picture! Potluck with delicious dishes from around the 🌎. Very thankful to an amazing group advancing #science by bringing together their different perspectives! #ThisIsWhatScientistsLookLike

Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses https://www.medrxiv.org/content/10.1101/2024.10.08.24315111v1

Our new study led by Eleni Friligkou is out on Molecular Psychiatry! Leveraging #AllofUsResearchProgram #fitbit data, we investigated how #anxiety polygenic risk and #antidepressants independently affect pulse rate variability, also when accounting for comorbidities. www.nature.com/articles/s41...

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

Just added the 106th amazing statistical/psychiatric geneticist! Even if you have seen this starter pack before have a look, find the new people filtering in!