Hello/goodbye C-17 low-level over Keechelus Lake, WA, seen from I-90

It's a common misconception that Reed College (in Portland, Oregon) has the only nuclear reactor operated by undergraduate students. In fact, though, the Idaho State and UNM reactors are also student-run

Good opportunity to adopt a quarter system!

I cannot believe this is a real thing. If you are in Laurelhurst and are bothered by the helicopter noise from Seattle Children's Hospital to the degree that you think signing this petition is in anything other than unconscionable, move. You can afford it.

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Can we use #proteindesign to develop countermeasures before viruses cause pandemics? We describe the computational design of an ultrapotent and broadly neutralizing deltacoronavirus miniprotein in our latest work led by Nathan Avery @hhmi-science.bsky.social 1/12 www.pnas.org/doi/10.1073/...

How are host proteases promoting coronavirus entry into cells? Find out by reading our latest manuscript led by @mattmccallum.bsky.social Brett Case Jack Brown & @youngjunpark.bsky.social in collaboration with @msdiamondlab.bsky.social 1/19 www.nature.com/articles/s41...

Yay proportional editing is now available in the Coot 1 API (in the daily)! This alters the sphere of influence of dragged refinement, which helps a lot when making large adjustments - register shifts of helices, domain movements, etc. I've added in a little widget to set it in coot1-trimmings.

"Something about the air hits different today" - student getting off the bus (1st year?) It's Springtime in Seattle, welcome to the other side! 🌇

NASA solution: superparamagnetic resin dice (zero residual magnetism), electromagnetic game table activates when photodiodes occluded by dice CCCP solution: dice cup

Fresh (after resting), Javanese anaerobic fermentation

The proteina-complexa paper is the 2nd this month suggesting that high K+E content, a staple of ProteinMPNN designs, is predictive of poor expression (the bits in bio benchmark paper showed a few weeks ago). In their case, they measure poor sequence recovery in phage display

I <3 you too King County Metro

"Submitting the AAM to PMC does not require payment to the publisher or publishing open access. Federal agencies have, by law, certain rights to products resulting from federal funding under the “Government Use License”... 1/2

🤘

I'm waiting for the bus, bunch of kids just drove through campus in an open top Model A, bumping music, no headlights (Actual Model A, a really fly restoration, all blue, historical plates)

There are right and left handed tubes in this bag and it's mildly disturbing 😨

Wave Interference, Ink on Yupo, 2026

Good to see the PhD lab is still following the rules

The new ChimeraX CubeNTube plugin allows erasing parts of maps using cube, cylinder, and custom shapes and has undo. Created by Tamino Cairoli. Available from ChimeraX menu Tools / More Tools....

Share a movie you incorrectly think no one else remembers 😇

I really like these

What speaks all languages, but has no voice? Would be silent, but has no choice? As old as the air, it spoke only when we did.

Pacific chorus frogs aptly named 🐸

The most important command IMO: help ChimeraX includes the online documentation in a built-in viewer. Guarantee you'll learn something useful if you read these three... help alias help functionkey help view

priviliged to be witnessing these amazing cellular vistas! makes you wonder about all the unknownwhat biology is being captured here!

My god man what's happened to you

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered. This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red. 1/

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

holy shit PR from an ‘agent’ gets closed so it writes a blog post with a personal takedown Some interesting comments from the maintainers too Slop machine go brr, dead internet theory x1000 github.com/matplotlib/m...

The striped HSB Silverfish. Lives in the basement of UWMC on a diet of hematology journal backissues from the 1950s. Much faster than regular silverfish, and camouflaged to match the floor.

I can see the lab from up here! 🔬 #cryoem

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

Alcatraz Coyote vs Alameda raccoon?

The trainees when you're at the GRC:

Great video (and voice over)! Missing sound effects though 😉

Quote with a movie that's 10/10? Mitsuo Yanagimachi's "Who's Camus anyway?" (Kamyu nante shiranai) doesn't even have a Wiki entry, but is as close to filmically perfect as anything

Very much so, but for every kind of lysate! Also start with most highly cited Abs (check citeab.com), more likely to work but if they don't at least you'll know which papers are affected...

The return of "water memory," ironically at one time a (partial) motivator of serious science... "liquid water essentially loses the memory of persistent correlations in its structure within 50 fs."

NEW article by me! We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before. We're living through a golden age of vaccine development, but only if we continue to invest in them.

My old Sherpa/Free Radical had been sitting around for a few years until my 2nd oldest friend and I tracked down possibly the last surviving kid-carrier hardware (thanks @xtracycle.bsky.social!) and now he's *safely* taking his kids everywhere with it 🤩 (1st oldest is his wife btw)

I'm really excited to break up the holiday relaxation time with a new preprint that benchmarks AlphaFold3 (AF3)/“co-folding” methods with 2 new stringent performance tests. Thread below - but first some links: A longer take: fraserlab.com/2025/12/29/k... Preprint: www.biorxiv.org/content/10.6...

Sprained an ankle and broke my glasses, separate shows at 924 ❤️😈

Wildcat soap dispenser ("environmental powder") 🤔

Can't sleep, thinking about molecular puppetry again

I could actually hear the sound garden today!

Dans la plaine naît un bruit. C'est l'haleine de la nuit. Elle brame comme une âme qu'une flamme toujours suit!

"so far as anything is wrong" 💀

What have we here?