Alcatraz Coyote vs Alameda raccoon?

The trainees when you're at the GRC:

Great video (and voice over)! Missing sound effects though 😉

Quote with a movie that's 10/10? Mitsuo Yanagimachi's "Who's Camus anyway?" (Kamyu nante shiranai) doesn't even have a Wiki entry, but is as close to filmically perfect as anything

Very much so, but for every kind of lysate! Also start with most highly cited Abs (check citeab.com), more likely to work but if they don't at least you'll know which papers are affected...

The return of "water memory," ironically at one time a (partial) motivator of serious science... "liquid water essentially loses the memory of persistent correlations in its structure within 50 fs."

NEW article by me! We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before. We're living through a golden age of vaccine development, but only if we continue to invest in them.

My old Sherpa/Free Radical had been sitting around for a few years until my 2nd oldest friend and I tracked down possibly the last surviving kid-carrier hardware (thanks @xtracycle.bsky.social!) and now he's *safely* taking his kids everywhere with it 🤩 (1st oldest is his wife btw)

I'm really excited to break up the holiday relaxation time with a new preprint that benchmarks AlphaFold3 (AF3)/“co-folding” methods with 2 new stringent performance tests. Thread below - but first some links: A longer take: fraserlab.com/2025/12/29/k... Preprint: www.biorxiv.org/content/10.6...

Sprained an ankle and broke my glasses, separate shows at 924 ❤️😈

Wildcat soap dispenser ("environmental powder") 🤔

Can't sleep, thinking about molecular puppetry again

I could actually hear the sound garden today!

Dans la plaine naît un bruit. C'est l'haleine de la nuit. Elle brame comme une âme qu'une flamme toujours suit!

"so far as anything is wrong" 💀

What have we here?

Posts about Cherry Blossoms have me wondering what folks think about Aplets & Cotlets, Washington state's own controversial candy.

Sad to hear...his F'05 Physics 5A (kinematics) was one of my first classes at UCSC. The cold dark matter co-discoverer was an engaged & engaging lecturer & his course was a warm welcome before the difficulty ramped up later in the series (David Dorfan taught 5B that year)

Makes a quiet thunderclap in my brain

King County ballot tracker

I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA! In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.

An obituary any scientist would be proud of imo

The Seattle Times paywalling their editorial argument against the measure that hikes their own taxes is very funny. The art of persuasion indeed @theneedling.com

People are confused about the title. It's only the first entry of a 10-part, 36-hour immortalization of Frank's journey

Evenin', guv

To any editor having trouble finding reviewers - try asking postdocs! We are available, we take it seriously, we know exactly what we're asking from the authors

Is this a pin cherry? Location is Seattle, WA on a residential property developed in the last 20 years or so...asking because my dog tastes the fallen berries #plants #trees #species

Javanese anaerobic via Sweet Maria's. Lighter than expected; it's cold this afternoon

Another undergraduate paper discussion today! This time we are doing Ron Vale's 1985 kinesin trifecta. Focusing on [1] & [3]. 🧪🔬 [1] www.sciencedirect.com/science/arti... [2] www.sciencedirect.com/science/arti... [3] www.sciencedirect.com/science/arti... [4] www.ibiology.org/cell-biology...

Honestly pretty GD sick of Google's search chatbot telling me specific, and very real, terms don't exist or "likely derive from lorem ipsum" 🤬

The real harm to #LongCovid patients isn’t coming from most doctors or scientists; it’s coming from activists spreading false claims about COVID-19, twisting science, and vilifying experts. Misrepresentation doesn’t help patients; it isolates them from real care. 1/10

Difference in kind when nothing distinguishes the marginal funded proposal, or when funding is so risk averse that many safe projects are passed over too

Lol

Discussed this classic paper with my undergrad reading group today. Still great 😎 🧪🔬

Gough maps.app.goo.gl/L7V61wxjJcSH...

I'm only surprised Kan selection was classified as "gain of function" before pseudotyping

Is it normal for SimpleFold to leave a bunch of stuff tangled in a knot right on top of the packed core of the rest of the structure (clashing terribly)? Alpha would loop it around the outside, maybe feed the active site its own tail...definitely less jarring #alphafold

What is this step 😂

Pretty excellent demo in the first two minutes #TeamTomo #CryoET

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Henriette taught me how to work efficiently and have fun doing it... and so, so much about membrane protein biochemistry. Truly incomparable mentor to have for a whole PhD! 🧪🎓 I bet the commute would be nice too 🚲🚲

Trespassing in the temple

Hey #microscopy 🧪 folks. Have you all noticed similar dark current patterns with cameras where you have a nonlinear response to exposure time? 100ms and 1s exposures are extremely quiet but once I do a 60s exposure, certain pixels just get super bright.

Sir, aren't you a little young to have your contractor license

Aha, a Ms. Pacman/Galaga arcade cabinet! They have a secret "feature"

"It's an older code but it checks out" - killer work from my friend and mentor DR. AMBER SMITH shows how HIV RNPs hijack host machinery to build their own nuclear export complexes 🦠🔬🧪

Don't taunt me, Micro$oft

Is anyone using a nitrogen gas generator instead of a high-pressure liquid cylinder to feed a cryo-FIB heat exchanger? Just wondering - seems like commercial generators (e.g. for LC-MS) can make ~3-5x the needed flow with a slightly smaller footprint #TeamTomo

Our latest preprint on peroxisomal fatty-acid transport is live!! @ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

It all makes sense once you know lizard 🤌 ↪️ eats paper and Spock 🖖 disproves it (Lizard poisons Spock, scissors decapitates/rock crushes lizard, Spock smashes scissors, Pon Far I guess, and vaporizes rock w/ phaser)