New paper! Specific PilA and PilY1 sequences make PilU dispensable for T4P-dependent twitching motility in P. aeruginosa. However, most suppressors still had high cAMP levels from loss of PilU, showing that motility and surface sensing responses can be uncoupled.🧐 ⏩ journals.asm.org/doi/10.1128/...

Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing. journals.asm.org/doi/10.1128/... @asm.org

Outbreaks of Marburg virus (MARV) disease have been increasingly more frequent recently. Here we describe a prefusion-stabilized MARV GP and a best-in-class MARV neutralizing antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses. Led by @aminaddetia.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly. www.nature.com/articles/s41...

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...

Deconvolution to restore cryo-EM maps with anisotropic resolution https://www.biorxiv.org/content/10.1101/2025.02.23.639707v1

Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine pubmed.ncbi.nlm.nih.gov/39970181/ #cryoem

With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr www.cell.com/cell/fulltex...

Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM www.science.org/doi/10.1126/...

Here, we show that SARS-CoV-2 nsp1 inhibits translation in a wide range of mammalian cells from known hosts (deer, mink, cat, dog,...) & unveils the architecture of a Rhinolophus bat ribosome with mRNA channel obstructed by nsp1! Led by Risako Gen @hhmi.bsky.social www.biorxiv.org/content/10.1...

Indeed - thank you David Goodsell for bringing science to life with art! Seeing the pilus motor featured is still my favourite grad school memory doi.org/10.2210/rcsb...

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social journals.plos.org/plospathogen...

Our latest work stabilizing the gB fusion protein. This paves the way for next-gen vaccines against Herpesviruses implicated in cancer, MS, and dementia. 🔗 www.biorxiv.org/content/10.1... #herpesvirus #EBV #HSV #CMV #proteindesign #virology #immunology