Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.nature.com/articles/s41...

Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...

Outbreaks of Marburg virus (MARV) disease have been increasingly more frequent recently. Here we describe a prefusion-stabilized MARV GP and a best-in-class MARV neutralizing antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses. Led by @aminaddetia.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

In these 2 papers, we show that two merbecovirus clades (HKU5 & MOW15-22, distantly related to MERS-CoV) independently evolved ACE2 receptor utilization, reshaping our understanding of coronavirus evolution Led by Young-Jun Park on our side! @hhmi.bsky.social www.cell.com/cell/fulltex...

Here, we show that SARS-CoV-2 nsp1 inhibits translation in a wide range of mammalian cells from known hosts (deer, mink, cat, dog,...) & unveils the architecture of a Rhinolophus bat ribosome with mRNA channel obstructed by nsp1! Led by Risako Gen @hhmi.bsky.social www.biorxiv.org/content/10.1...