Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome. We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social

Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social! Download our code and try it yourself. 🥳

Important insights into FCoV-23 cell entry from the @veeslerlab.bsky.social Freely available: www.nature.com/articles/s41...

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics pubmed.ncbi.nlm.nih.gov/40634609/ #cryoem

Our paper describing how in-host evolution of a recently emerged, highly pathogenic coronavirus modulates entry into cells, membrane fusion and likely pathogenicity has now been published in its peer-reviewed form! Led by Ale Tortorici! @hhmi.org www.nature.com/articles/s41...

Our effort to try to do something for [cystic fibrosis (CF)] started as a basic science enterprise. That was a hard slog back in the 1980s. Nobody would have supported except NIH. Now, 30 years after that discovery, young people with CF get to plan for retirement instead of an early funeral.

Congratulations @stanford-chemh.bsky.social Institute Scholar @cobarnes27.bsky.social on being named a 2025 Freeman Hrabowski Scholar @hhmi.org 🎉 🍾 www.hhmi.org/programs/fre...

I have exhorted others to share positive news even in these uncertain times for US science. I am really excited that @tamanash.bsky.social’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online. Follow along here 🧪🧵

Outbreaks of Marburg virus (MARV) disease have been increasingly more frequent recently. Here we describe a prefusion-stabilized MARV GP and a best-in-class MARV neutralizing antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses. Led by @aminaddetia.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines https://www.biorxiv.org/content/10.1101/2025.05.11.652904v1

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife: elifesciences.org/articles/101...

Excited to be giving this webinar soon. Hope to see you then!

Congrats to Jeremy Hollis on receiving the Weintraub Award! A well-deserved recognition to a person who exemplifies (and resembles?) Hal.

#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

We show that the HKU25 clade of merbecoviruses utilizes the ACE2 receptor with a binding mode sharing similarity to HKU5, suggesting a common evolutionary origin of ACE2 utilization. Led by Young-Jun Park on our side. Collab with Huan Yan's lab! @hhmi.bsky.social www.biorxiv.org/content/10.1...

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

In these 2 papers, we show that two merbecovirus clades (HKU5 & MOW15-22, distantly related to MERS-CoV) independently evolved ACE2 receptor utilization, reshaping our understanding of coronavirus evolution Led by Young-Jun Park on our side! @hhmi.bsky.social www.cell.com/cell/fulltex...

Calling all structural enthusiasts! An accurate depiction of the structure of DNA in #Lego is under 2000 supporters away from being considered to become a real set! It even has Franklin, Watson, and Crick minifigures and a Lego photgraph 51 and Bragg's law! ideas.lego.com/projects/c92...

Here, we show that SARS-CoV-2 nsp1 inhibits translation in a wide range of mammalian cells from known hosts (deer, mink, cat, dog,...) & unveils the architecture of a Rhinolophus bat ribosome with mRNA channel obstructed by nsp1! Led by Risako Gen @hhmi.bsky.social www.biorxiv.org/content/10.1...

We sequenced the anti-RSV-F antibody 131-2a by mass spec, then mapped its epitope by cryoEM. It's widely used to study the antigenic landscape of F, but its sequence wasn't known. Check it out in our new preprint and find it on Addgene: www.biorxiv.org/content/10.1... www.addgene.org/Joost_Snijder/

Thrilled to share that I have been selected as one of this year's new EMBO Young Investigators. I look forward to meeting many of the other Young Investigators in the coming years, and I am most grateful to the members of my laboratory at the ICR who made this possible. www.embo.org/press-releas...

Our latest work stabilizing the gB fusion protein. This paves the way for next-gen vaccines against Herpesviruses implicated in cancer, MS, and dementia. 🔗 www.biorxiv.org/content/10.1... #herpesvirus #EBV #HSV #CMV #proteindesign #virology #immunology