The Menachery Lab
@themenacherylab.bsky.social
📤 1670
📥 301
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A coronavirus lab looking for low hanging pebbles and shiny fruit. Emory University
Great regional conference for virologist in the southeast. Abstract due next week.
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24 days ago
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"This is pitiful. A thousand people freezing their butts off waiting to worship a rat. What a hype. Groundhog Day used to mean something in this town. They used to pull the hog out, and they used to eat it. You're hypocrites, all of you!"
about 1 month ago
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The Menachery Lab
Tim Sheahan
about 2 months ago
Our new preprint on
#SARSCoV2
nsp14
#exonuclease
function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o
#interferon
signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo
www.biorxiv.org/content/10.6...
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Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2
Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...
https://www.biorxiv.org/content/10.64898/2026.01.12.698941v1
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Our paper on the role of
#SARSCoV2
NSP3 in stress granule control is now out in JVI. Reposting our original BioRXIV thread on the summary.
journals.asm.org/doi/10.1128/...
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about 2 months ago
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I-75 Scientist
2 months ago
Excellent news. The NIGMS Building Undergraduate Research Training (BURT) T34 NOFO is published. First due is Feb 25th, for December 26 funding. This condenses previous UG NOFOs so reach out to email/previous PO if you have Qs.
files.simpler.grants.gov/opportunitie...
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PAR-26-033: NIGMS Institutional Biomedical Undergraduate Research Training (BURT) Program (T34)
https://files.simpler.grants.gov/opportunities/d88aea72-290a-4396-83ba-139886a6ffc8/attachments/e59a911d-8bc5-483a-a7e0-0d1ac27bff83/PAR-26-033-Full-Announcement.html
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The Menachery Lab
Yiyang (Tommy) Zhou
3 months ago
The very first
@nanoporetech.com
MinION library of
@themenacherylab.bsky.social
at Emory! So far so good! I've been missing Nanopore for a while! Merry Christmas!
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The Menachery Lab
Mehle Lab
3 months ago
🧵 Thread on our new
@natcomms.nature.com
paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11)
www.nature.com/articles/s41...
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature Communications
Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.
https://www.nature.com/articles/s41467-025-66136-6
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The Menachery Lab
Chris Morran
3 months ago
When Hannah’s pharmacy began filling her tacrolimus prescription with a generic version, the lung transplant patient didn't know something very important: Months earlier, an FDA-commissioned study concluded that this generic was not equivalent to the brand drug -- and that her life was at risk.
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Fighting for Breath: The FDA’s Lax Generic Drug Rules Put Her Life at Risk
Lung transplant patient Hannah Goetz’s life depended on the generic version of the critical drug tacrolimus. It was supposed to be equivalent to the brand-name medication — but the FDA doesn’t always ...
https://www.propublica.org/article/fda-generic-drug-equivalents-tacrolimus
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Ryan Langlois
3 months ago
Put a perspective piece together on how fever may have driven the evolution of antiviral genes:
rupress.org/jem/article/...
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Does fever drive the evolution of antiviral genes? | Journal of Experimental Medicine | Rockefeller University Press
Fever is an evolutionary conserved response to pathogens. In this Perspective, Langlois hypothesizes that antiviral genes are selected for their function a
https://rupress.org/jem/article/223/1/e20251747/278566/Does-fever-drive-the-evolution-of-antiviral-genes
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reposted by
The Menachery Lab
Prof Peter Hotez MD PhD DSc(hon)
3 months ago
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The Menachery Lab
Chris Brooke
3 months ago
Check out
@lizthayer.bsky.social
's new preprint exploring factors that influence cell-to-cell heterogeneity in interferon (IFN) induction potential!
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The Menachery Lab
Priya Shah
3 months ago
Are you an early career researcher applying to faculty positions this cycle? My #1 piece of advice is to keep an open mind about what the right department looks like. You might be surprised.
journals.asm.org/doi/10.1128/...
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On professional mutualism: a blueprint for early-career virologists | Journal of Virology
As virologists, we are constantly studying symbiosis. Viruses are obligate intracellular parasites and symbionts as a result. Symbiotic virus-host relationships can be antagonist, neutral, or mutualistic for the host (1). It is these mutualistic relationships that are perhaps the most curious. How can a virus, which uses cellular resources, benefit a host? It all depends on context and the right conditions for mutualism to emerge. However, we should not stop at understanding virus-host mutualism from a scientific perspective. We should also consider mutualistic symbiotic relationships in our careers. The right conditions for professional mutualism in virology may surprise you.
https://journals.asm.org/doi/10.1128/jvi.01156-24
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New paper from our lab on CoV recombination in
@natcomms.nature.com
:
www.nature.com/articles/s41...
Collaboration w/
@andrewrouth.bsky.social
, the work led by
@tommygottago.bsky.social
& Yani provides insights into
#SARS2
recombination & immune induction. Some takeaways for the TLDR crowd (1/13)
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SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness - Nature Communications
Known to augment host innate immunity, Zhou and Ahearn et al. shows that a SARS-CoV2 NSP15 mutant also increases viral recombination and reduces sub-genomic message. Results articulate a novel role fo...
https://www.nature.com/articles/s41467-025-67001-2
3 months ago
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A new preprint from our group on control of stress granules (SGs) by
#SARSCoV2
. Working with Jakob Nilsson's group, we identified key residues in SARS2 NSP3 critical for binding FMRP proteins & disrupting SGs formation.
www.biorxiv.org/content/10.1...
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Key residues in SARS-CoV-2 NSP3 hyper variable region are necessary to modulate early stress granule activity.
Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and...
https://www.biorxiv.org/content/10.1101/2025.11.22.689758v1
3 months ago
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A nice honor to be named to Clarivate’s Highly Cited Researchers for 2025. The recognition is a testament to all the hard work my research group and our collaborators have done over the years.
news.emory.edu/stories/2025...
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Nine Emory faculty recognized among world’s most influential researchers in 2025 | Emory University | Atlanta GA
Nine Emory faculty members are among the list of the world's most influential and highly cited researchers for 2025, as compiled by the data analytics firm Clarivate.
https://news.emory.edu/stories/2025/11/hs_highly_cited_researchers_11_11_2025/story.html?fbclid=IwY2xjawOC4RRleHRuA2FlbQIxMQBzcnRjBmFwcF9pZBAyMjIwMzkxNzg4MjAwODkyAAEeLhWoQpL_u8TeuvI8r_xfQelJkHfrWbf2W5zNPRS1_0UHGku756I-kJEl1Yk_aem_p6I9M0DORSJEhWq7s4fVag
4 months ago
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Tim Sheahan
4 months ago
New
#coronavirus
#postacute
lung pathogenesis paper from my friend Dr. John Powers is up at
@asm.org
JVI.
journals.asm.org/doi/10.1128/...
Confusing as to why this link shows a rotund blue bird.
#PASC
#SARSCoV2
#Omicron
#LoveVirology
#JVI
#ASM
#virology
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Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology
To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants of concern, the development of effective small animal models is of critical importance. Herein, we describe the de...
https://journals.asm.org/doi/10.1128/jvi.01406-25
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The Menachery Lab
The Lustgarten Foundation
5 months ago
NIH will spend its full $48B budget — but multi-year funding means fewer projects, record-low grant success, and a warning for U.S. science.👉
lfdn.org/3KOs2hT
💜Learn how you can support NIH funding:
www.lustgarten.org/forging-ahead
#ResearchMatters
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Feels like everything has moved slow since restarting here at Emory last year, but glad to have been nominated by my new peers and selected for this recognition.
med.emory.edu/about/facult...
6 months ago
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I wish my all my students labeled their figures as well as my daughter.
6 months ago
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The Menachery Lab
jamelle
6 months ago
there is no question in my mind that rfk jr is the most dangerous person in this administration and that his eugenicist ideology threatens the lives of millions of people
www.advocate.com/politics/dem...
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RFK Jr.’s damage to the CDC is ‘past the point of no return,’ Dr. Demetre Daskalakis warns
“The CDC you knew is over,” the infectious diseases doctor told The Advocate. “Unless someone takes radical action, there is nothing there that can be salvaged.”
https://www.advocate.com/politics/demetre-daskalakis-cdc-resignation-interview
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The Menachery Lab
Marc Veldhoen
6 months ago
What the CDC lost: a closer look at the top-ranking officials who have quit HHS Secretary RFK Jr. says agency suffers from ‘malaise,’ but departed officials had deep expertise Knowledge, experience and talent lost due to political ideology.
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What the CDC lost: a closer look at the top-ranking officials who have quit
Here is a closer look at the top-ranking officials who resigned from the CDC this week.
https://www.statnews.com/2025/08/28/profiles-cdc-officials-who-resigned-in-protest/
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The Menachery Lab
Demetre Daskalakis
6 months ago
Enough is enough. The health of the country is in danger. Read our resignation letters:
insidemedicine.substack.com/p/breaking-n...
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Breaking News: Read three top CDC officials' resignation emails.
The end of an era.
https://insidemedicine.substack.com/p/breaking-news-read-three-top-cdc
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The Menachery Lab
Eric Columbus
6 months ago
Wow
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Journal of Experimental Medicine
7 months ago
#WomenInSTEM
becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher:
rupress.org/jem/article/...
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www.wabe.org/man-fired-18...
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Man fired 180 shots, breaking 150 windows, in CDC attack
The man who attacked the CDC headquarters in Atlanta on Friday fired more than 180 shots into the campus and broke about 150 windows, with bullets piercing “blast-resistant” windows and […]
https://www.wabe.org/man-fired-180-shots-breaking-150-windows-in-cdc-attack/?fbclid=IwY2xjawMIHopleHRuA2FlbQIxMQBicmlkETFGWm9acFlRY0Z6cGRUTWNOAR6_PqAmY24GXd5ADlLaBdnkexmAL7hR4AZdX-L3yASU5hstWNcPRnXfhKmuMA_aem_pYx-UpmoIIfw4NjSw-IQFg
7 months ago
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Spent the weekend here reflecting & reconnecting. A sorrowful few days thinking of what was lost. The CDC is ubiquitous to our community. An attack on us all. Officer David Rose died protecting us. Take a moment to support & share efforts for the family he left.
www.gofundme.com/f/7xahr9-off...
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Donate to Officer Rose's Official GoFundMe, organized by Mrs Rose
Officer David Rose was more than a dedicated public servant - He was a loving father, a dev… Mrs Rose needs your support for Officer Rose's Official GoFundMe
https://www.gofundme.com/f/7xahr9-officer-roses-official-gofundme/cl/s?utm_campaign=fp_sharesheet&utm_content=amp13_c&utm_medium=customer&utm_source=copy_link&lang=en_US&attribution_id=sl%3Ac7288166-b1c9-4a52-9c18-773e663b30e6&ts=1754914468
7 months ago
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Lab members in ATL are all accounted and safe.
7 months ago
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#ASV2025
is where you run into a Nobel Laureate at the bar late at night and they wish you a happy birthday. My birthday is in March. But thanks. Happy birthday
@lakdawalalab.bsky.social
8 months ago
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Recycling an old twitter thread for
#ASV2025
: Heading to
#ASV2023
. One of my favorite meetings in virology. My new students asked me for some tips on how to approach the meeting, so I thought I’d share some thoughts on scientific networking
8 months ago
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The Menachery Lab
Arinjay Banerjee
8 months ago
🚨Second study from the lab. @CellReports SARS-CoV- and SARS-CoV-2-like viruses are found in insectivorous bats, but the antiviral responses in these bats remain less studied. Here we show how bat cells respond to SARS-CoV-2 and shed light on virus entry.
www.cell.com/cell-reports...
#LZCI
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Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells
Baid et al. show that insectivorous E. fuscus bat cells have evolved an advantageous early innate immune response to SARS-CoV-2 infection relative to human cells. Additionally, they extend molecular e...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00700-4
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The Menachery Lab
Dr. Kat Napaaqtuk❄️
9 months ago
A short thread about the people in my lab who will present posters and give rapid talks at
#ASMmicrobe
: 🧵
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The Menachery Lab
9 months ago
Excited for the recipient of the @ASM Elizabeth O. King Lecturer Award at this year’s
#ASMMicrobe
.
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2 in a row in the Journal of Virology. A new paper from our group & the new Johnson lab at UTMB. Here, we find multiple variant mutations in the SR rich domain of N facilitate improved infection with
#SARS2
. A brief thread since this didn't get preprinted
journals.asm.org/doi/10.1128/...
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Convergent evolution in nucleocapsid facilitated SARS-CoV-2 adaptation for human infection | Journal of Virology
After its emergence, SARS-CoV-2 rapidly adapted to human infection, acquiring numerous mutations across its genome. Many of these mutations remain uncharacterized. This study examines a mutational hot...
https://journals.asm.org/doi/10.1128/jvi.02091-24
9 months ago
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Our new paper on SARS-CoV-2 furin cleavage site is now out at JVI. Study examines disruption (rather than deletion) of the FCS & maintains the longer S1/S2 loop found in
#SARS2
. FCS disruption attenuates pathogenesis, but not required (but helps) transmission.
journals.asm.org/doi/10.1128/...
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The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2 | Journal of Virology
The presence of the furin cleavage site (FCS) within the spike protein of SARS-CoV-2 distinguishes it from other sarbecoviruses found in nature. While prior works have deleted the FCS, these mutant viruses also shortened the S1/S2 loop, which is known to ...
https://journals.asm.org/doi/10.1128/jvi.00467-25
9 months ago
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PLOS Biology
10 months ago
Non-spike protein mutations in
#SARSCoV2
, likely to impact viral properties, are understudied.
@brucelab.bsky.social
show that a
#nucleocapsid
protein mutation in Delta variant enhances viral growth in vitro & in vivo by increasing viral genome
#encapsidation
@plosbiology.org
🧪
plos.io/4iBYsaI
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The Menachery Lab
Harmit Singh Malik
11 months ago
I have exhorted others to share positive news even in these uncertain times for US science. I am really excited that
@tamanash.bsky.social
’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online. Follow along here 🧪🧵
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Absolutely. The work by
@tamanash.bsky.social
is a tour de force and an example of clever, beautiful science towards better understanding of alphavirus biology. Based on what I heard, an example of a great post-doc & future star in virology. Read his preprint:
pubmed.ncbi.nlm.nih.gov/39229031/
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11 months ago
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Really interesting talk from
@harmitmalik.bsky.social
on alpha virus evolution and the opal codon. A little rusty and just barely got
#bingo
. Need to get back to it.
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11 months ago
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It these trying time, we need to lean on what we do best. For me, that means
#bingo
for MMG seminar with
@harmitmalik.bsky.social
A good speaker to start this back up at Emory.
11 months ago
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The Menachery Lab
Chris Brooke
12 months ago
Excited to share
@joelrc.bsky.social
's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection:
www.biorxiv.org/content/10.1...
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Intrinsic OASL expression licenses interferon induction during influenza A virus infection
Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ...
https://www.biorxiv.org/content/10.1101/2025.03.14.643375v1
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A new preprint from our group about the importance of the SARS-CoV-2 spike furin cleavage site (FCS) for pathogenesis and possibly transmission.
tinyurl.com/2dya48ky
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The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2
The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecovirues: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop charac...
https://tinyurl.com/2dya48ky
12 months ago
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After an uneasy start to 2025 some good news to start the week: 1) I received tenure once again, now at Emory. A real honor & recognition of the work we have done over the past 8 years. 2) We celebrated the 3 year anniversary of my kidney transplant. Time flies when you aren't on dialysis.
12 months ago
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The Menachery Lab
Andrew (Andy) Broadbent
about 1 year ago
Hi everyone, to counter the doomscrolling, I would like to put out there that I am looking to recruit a postdoc to start this spring/summer- preferably someone with prior virology experience. Please forward. Thank you!
#virologysky
#lovevirology
#sciencesky
umd.wd1.myworkdayjobs.com/UMCP/job/Uni...
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Postdoctoral Associate
Job Description Summary Organization Summary Statement: Andrew Broadbent, DVM, PhD, in the department of Animal and Avian Sciences at the University of Maryland (UMD), College Park, is recruiting a po...
https://umd.wd1.myworkdayjobs.com/UMCP/job/University-of-Maryland-College-Park/Postdoctoral-Associate_JR100990
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The Menachery Lab
Priya Shah
about 1 year ago
Everything is shit but I give you the Joe and Essie Smith Chair in the Joe and Essie Smith Chair!
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The Menachery Lab
Rafael Kroon Campos
about 1 year ago
Come be our colleague at the Department of Microbiology and Immunology at Cornell! It is a highly supportive environment with exciting science. I am extremely inspired by the extraordinary people here. We are located in beautiful Ithaca, NY.
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The Menachery Lab
Ashley Esqueda
about 1 year ago
Kendrick Lamar deserves to win the very first Nobel Hate Prize
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The Menachery Lab
Tim Clancy
about 1 year ago
On changes to
#NIH
indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47)
grants.nih.gov/grants/guide...
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NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-24-110.html
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American Society for Virology
about 1 year ago
Shoutout to all of the exceptional Black scientists who have contributed to and are currently contributing to virology research! Your work is vitally important to understanding basic virology controlling viral diseases worldwide!
#BlackHistoryMonth
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