Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Welcome to the Fascist States of America, where the EiC of a leading journal is forcibly removed by police for passing out his own editorial at the annual meeting of the field’s association…because it’s “too political” (read: it calls on scientists to speak out & stand up). We are here. This is it.

This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution. Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!

On OMB's proposal to make all grants political: "Speak up! Now’s the time! Standing by the side of the room, glancing around nervously and hoping that somebody else does something will lead us to disaster. These are not normal times, so stop acting as if they are." www.science.org/content/blog...

Check out our new review with @mfarjo.bsky.social on what we know about the functional and evolutionary consequences of virus-virus interactions within viral populations, out now in @annualreviews.bsky.social: www.annualreviews.org/content/jour... Hope you like it!

Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...

I'm very excited to share this preprint led by @sorenlouislarsen.bsky.social and Chloe Yand, and made possible by the collaboration with my friend and colleague @ayesha-mahmud.bsky.social. www.medrxiv.org/content/10.6...

If you wish to submit a public comment on this, you can do so at www.regulations.gov/commenton/OM.... Public comments regarding the legality of the rule, how arbitrary and capricious the changes are, negative impacts on cities and states, etc can be used as evidence in subsequent lawsuits.

This is bad. Bad for researchers. Bad for science. Bad for universities. Bad for professional associations. For example: 1. Every award would be vetted by political appointees, who could overrule peer reviewers and deny the award if it doesn't advance the president's priorities. 1/🧵

And, here, in much more detail. This is an absolutely critical read for all federally funded scientists and institutions. Now is not the time to sit in the corner, hoping you won't be noticed - now is the time for action. elizabethginexi.substack.com/p/summary-of...

Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.

Please share widely! Abstract submissions open for the 2026 Jacques Monod conference: Ecology and evolution of host-parasite interactions in a changing world! Held in beautiful Roscoff France from November 2- 6, 2026. Abstracts submission deadline : June 6 cjm.sb-roscoff.fr/en/conferenc...

Absolutely extraordinary work from Hui Gao, John Briggs and co @mpibiochem.bsky.social on the structure of the influenza matrix protein in situ, particularly in filamentous virions. It's beautiful, and answers questions I've been wondering about for twenty years www.biorxiv.org/content/10.6...

Latent endogenous giant viruses drive active infection and inheritance in a multicellular algal host www.nature.com/articles/s41...

Scoop: There has been a massive shakeup at the US National Institute of Allergy and Infectious Diseases (NIAID). Eight of the top ten officials have now been pushed out since President Donald Trump took office. In @nature.com www.nature.com/articles/d41...

Excited to announce that we are moving the lab to Minneapolis to join the University of Minnesota Department of Microbiology & Immunology and Institute on Infectious Diseases this summer!! We will be hiring so please reach out if interested in viral evolution, viral immunology, etc.!!

“HHS is punishing a world-class scientist who was working to protect people against pandemics, and if he had been listened to more thoroughly, we might have been better prepared for SARS-CoV-2” This might be the most insane thing yet. www.science.org/content/arti...

“The message, very clearly, they’re sending is, do not speak out on behalf of Chinese postdocs. If you do, you’re going to pay a penalty...It seems pretty obvious that this is an attempt by the current administration to silence people that question their activities." — Roger Innes, IU AAUP member

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes www.nature.com/articles/s41... @natcomms.nature.com

🚨Faculty job search: University of Illinois Chicago Micro & Immuno department is hiring! Open rank and open area within host-pathogen interactions. Apply by May 31 to join us in UI College of Medicine in the heart of Chicago! uic.csod.com/ux/ats/caree...

I haven't been out here much this year, but we have several cbVG papers out! check them out: 1. Yanling Yang generated several recombinant cbVG-free SeV stocks and studied the populations of cbVG as they were generated ...she found some very interesting population dynamics: doi.org/10.1128/jvi....

This is a straightforward question and deserves a public answer on the NIH website. The simplified review framework cannot also mean using a double-secret probation mechanism operating in the shadows to determine outcomes.

The Department of Molecular Microbiology and Immunology is looking to grow! We opened a position for an assistant or associate professor, please distribute ! facultycareers-ohsu.icims.com/jobs/39006/a...

"Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons " , enjoy a fresh review coming out from our lab (Zoé Denis, an amazing PhD student as first author) www.sciencedirect.com/science/arti...

Thrilled to have my first PhD paper with @mmdesai.bsky.social out! @science.org Link: www.science.org/doi/10.1126/... Thread below: #mevosky #evosky #evobio #popgen #evolsky #ecoevo #molevol

🚨New pre-print!🚨 Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles www.biorxiv.org/content/10.6...

Transient RNA structures play a key role in the emergence of highly pathogenic avian influenza viruses! Great to see this collaboration with Mathis Funk, Mathilde Richard, Stephen Cusack, and others in @science.org www.science.org/doi/10.1126/...

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

1. Numerous transgender people in Kansas are reporting that the state has sent them a letter demanding the immediate surrender of drivers licenses. Those driving could be arrested, charged, and see privileges revoked. Subscribe to support our journalism. www.erininthemorning.com/p/kansas-sen...

Should biology put complexity first? www.sciencedirect.com/science/arti... - excellent essay by @philipcball.bsky.social. I would add epistasis to polygenicity and pleiotropy as a ubiquitous and fundamental phenomenon, not some optional complication that we can try to account for afterwards

Out today in @natecoevo.nature.com! 📝 www.nature.com/articles/s41... We compare the mutational tolerance of enteroviruses A & B across their full proteomes, mapping distinct host interaction strategies 🦠 and identifying mutation-resistant regions that could inform antiviral development 💊

Thank you to @joshuasweitz.bsky.social. The origin of the current assault on science and public health has a direct tie to COVID contrarianism. But Bhattacharya, Prasad and the rest couldn’t rise without help and patronage. 1/ joshuasweitz.substack.com/p/grievance-...

A lot of people, including me, were wondering how an IRB could ever approve this study. The answer is that no IRB did. The person who “signed off” on approval from the only ethics board that reviewed it had resigned three years earlier. His signature was used without his knowledge.

In 2020, we mapped out the danger zones that will close in on Americans over the next 30 years — combining climate data with wildfire projections by US Forest Service researchers and others. See what changes are in store for your county 👇

Scoop: Top FDA official Vinay Prasad overruled the agency’s reviewers when he refused to accept Moderna’s application for a new influenza vaccine, STAT has learned. www.statnews.com/2026/02/11/m...

Integrated single-cell analyses of affinity-tested B cells enable the identification of a gene signature to predict antibody affinity @astrazeneca.bsky.social @angelettilab.bsky.social www.cell.com/cell-systems...

Last week in Minnesota, I watched ordinary people risk their lives to protect their neighbors. In the process, they not only won a significant—though not final—victory against authoritarianism, they proved virtually every MAGA social theory wrong. (gift link) www.theatlantic.com/ideas/2026/0...

This is the chair of ACIP. Experimenting on America's kids. HE'S GOT TO GO. “What we’re going to have is a real-world experience of when unvaccinated people get measles,” he said. “What is the new incidence of hospitalization? What’s the incidence of death?” www.statnews.com/2026/01/22/v....

Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought www.science.org/doi/10.1126/...

🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵

Excited to share: We show that basal IFNλ2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...

I came to Minneapolis to report on what's going on, and one of the main questions I showed up with is "just what is the scale of the resistance?" After all, we're all used to the news calling Portland a "war zone" or whatever when it's just some protests in one part of town.

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

Minnesota: "School officials say the [5-year-old] child was used as bait. They say [ICE] agents made little Liam knock on the door to ask to be let in in order to see if anyone else was home."

Now live! Nearly all human genes contain multiple transcript isoforms - and the genes that predominantly control infection, ISGs, are no different. Using PacBio with analysis help from Yan Guo, Himadri noticed a never-before-seen transcript isoform of ISG15 that potently restricts flu 1/4