This is the chair of ACIP. Experimenting on America's kids. HE'S GOT TO GO. “What we’re going to have is a real-world experience of when unvaccinated people get measles,” he said. “What is the new incidence of hospitalization? What’s the incidence of death?” www.statnews.com/2026/01/22/v....

Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought www.science.org/doi/10.1126/...

🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵

Excited to share: We show that basal IFNλ2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...

I came to Minneapolis to report on what's going on, and one of the main questions I showed up with is "just what is the scale of the resistance?" After all, we're all used to the news calling Portland a "war zone" or whatever when it's just some protests in one part of town.

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

Minnesota: "School officials say the [5-year-old] child was used as bait. They say [ICE] agents made little Liam knock on the door to ask to be let in in order to see if anyone else was home."

Now live! Nearly all human genes contain multiple transcript isoforms - and the genes that predominantly control infection, ISGs, are no different. Using PacBio with analysis help from Yan Guo, Himadri noticed a never-before-seen transcript isoform of ISG15 that potently restricts flu 1/4

The thing I always come back to is how many people never despaired against longer odds, and how arrogant it would be to put myself above them.

We find that subclade K viruses are antigenically advanced; however, this year's flu vaccine surprisingly elicited antibodies in many individuals that efficiently recognized these viruses. The implications are clear: go get this year’s vaccine if you haven’t already! www.medrxiv.org/content/10.6...

If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch. IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE. Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.

Three weeks ago I explained in @statnews.com why adopting Denmark’s vaccine schedule would leave American children unprotected. Today HHS did it anyway. www.statnews.com/2025/12/19/d...

Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form: www.pnas.org/doi/10.1073/... Happy new year, hope everyone's 2026 is better than 2025!

Macedo and Lee misrepresent what happened during the pandemic and are unable to confront Covid's actual toll, presumably because it undermines their premise. A longer take here w/my colleague Greg Gibson: joshuasweitz.substack.com/p/revisionis...

🧵 Thread on our new @natcomms.nature.com paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11) www.nature.com/articles/s41...

Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...

Check out @lizthayer.bsky.social's new preprint exploring factors that influence cell-to-cell heterogeneity in interferon (IFN) induction potential!

My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)

A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...

Meet the head of a federal panel expected to upend the childhood vaccine schedule later this week. Dr. Kirk Milhoan believes that Covid was made in North Carolina and deployed to China as a bioweapon ... among other conspiracy theories. www.ms.now/news/rfk-jr-...

Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...

Amazing example of influenza cheat/cooperator cycles in this recent paper - the repeatability of the oscillatory cycles is so striking Congrats to @alnajifg.bsky.social , @christopherbrooke.bsky.social , @vignuzzilab.bsky.social & friends www.biorxiv.org/content/10.1... 🧪 #socialviruses

This is wild. Remember the NJ crytic lineage? I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out. Some colleagues took me up on it. Guess what they found? 1/

Evolution of Ab cross-reactivity to influenza H5N1 NA: Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social www.cell.com/cell-host-mi...

Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...

Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social www.biorxiv.org/content/10.1...

Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research

New in ‘Virus Evolution’ from #QVEU! PhD student Jack Dorman used deep mutational scanning to measure evolutionary constraints on the Envelope protein of West Nile Virus in human, mosquito, and bird cell lines, doing a lot of work to put it into a structural context #VirEvol

Excited to announce that we have a new faculty search opening in the Department of Microbiology and Immunology at the University of Minnesota for a tenure track Assistant Professor in RNA Virology. More info can be found here: hr.myu.umn.edu/jobs/ext/365...

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

Evolution of Ab cross-reactivity to influenza H5N1 NA New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social www.cell.com/cell-host-mi...

Our paper on the phenomenon of persistence and latency in Ebola virus in an unobserved reservoir is finally out in preprint: www.biorxiv.org/content/10.1...

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells www.nature.com/articles/s41... @natimmunol.nature.com @idoyagalab.bsky.social

RFK fired the CDC official (w/decades of experience) leading the measles outbreak response. It's been decades since we've had such a large outbreak. And just to ensure they they can spread the measles outbreak even farther, they also fired the leadership for the center focused on immunization.

NEW: @CDCgov hit hard by massive firings that several staff describe to me as a “bloodbath.” Among those RIFd: —leadership of the center for immunization and respiratory diseases; —leadership of global health center —leadership of the measles outbreak response; 1/4

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

A large (2.5M+) sibling control analysis that found "no evidence of increased risk of autism, ADHD, or intellectual disability associated with acetaminophen use" seems to be the kind of data that requires serious consideration before declaring mission accomplished. jamanetwork.com/journals/jam...

Reporters on the ground in Chicago are screaming to be heard over the false narrative that Pritzker defeated Trump there. PLEASE listen to them.

New preprint! 🥳🎉 We looked at viral coinfection patterns at the largest scale ever in wildlife. We found a strong association among CoVs, PMVs, and influenza A, and higher coinfection rates in wildlife trade; plus, evidence that bats accumulate persistent infections. www.biorxiv.org/content/10.1...

Check the latest publication from our group! rdcu.be/ey1Fj @i2sysbio.es @csic.es

I'm thrilled to share that the oPool⁺ display is on the cover of this week's #ScienceTranslationalMedicine! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.

What causes viral transmission bottlenecks? This study uses barcoded virions to show that in the case of #influenza A #virus, early within-host replication dynamics (rather than a reduced inoculum population) drive loss of diversity during transmission @plosbiology.org 🧪 plos.io/4ngicDK

I took this picture myself at the CDC protest today. These are among the hundreds of bullet holes in CDC headquarters windows, visible from the street. I heard today that the admin has no urgent plan to fix these windows. Imagine being a CDC employee going to work under these conditions

Full resignation letter from Demetre C. Daskalakis, a CDC leader, does not hold back. "The recent shooting at CDC is not why I am resigning. My grandfather, who I am named after, stood up to fascist forces in Greece and lost his life doing so. I am resigning to make him and his legacy proud."

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

Anti-vaccine myths surged on social media ahead of the CDC shooting. “On X, for example, verified accounts with hundreds of thousands of followers openly claimed in recent weeks that Covid vaccines act like ‘chemical lobotomies,’ which is false.” www.nbcnews.com/tech/interne...

A terrorist targeted federal workers last week. There wasn’t much reporting on it. But I’m not finished thinking about it! 🧵 An anti-vaxxer fired more than 500 gunshots into CDC Atlanta, shattering 150 “blast-proof” windows on 6 buildings. Employees were pinned down in terror.