Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to #influenza. New study from Nimitha R. Mathew, Davide Angeletti @angelettilab.bsky.social and colleagues (University of Gothenburg): rupress.org/jem/article/... #Virology #MucosalImmunology #InfectiousDisease #HostDefense

New @jem.org study from Mathew et al. @angelettilab.bsky.social (rupress.org/jem/article/...) shows that nasal tissue harbours T cells that ‘remember’ a pathogen long after infection is past. See @nature.com research highlight: www.nature.com/articles/d41...

Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza @jem.org rupress.org/jem/article/... @angelettilab.bsky.social

CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/... #Virology #MucosalImmunology #InfectiousDisease

CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study in @jem.org by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/... #Virology #MucosalImmunology

Happy to share this paper led by super talented postdoc Michele Chirichella at @astrazeneca.bsky.social Published in @cp-cellsystems.bsky.social All kudos to him. Glad to have contributed as academic advisor and with some experiments and data. Hopefully first of many !

I’m excited to recruit a postdoc to join my lab at NIAID (Rocky Mountain Labs). We study mucosal immunity and vaccine responses to respiratory viruses in a collaborative, supportive environment. Details & apply: www.training.nih.gov/jobs/pdf-miv... #Postdoc #Immunology #Virology #NIHJobs

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals https://www.biorxiv.org/content/10.1101/2025.10.13.682194v1

I am really excited to see this article on basic experimental design principles published. Definitely will be mandatory reading for incoming graduate students in my lab. Maggie Wagner who led this article did an amazing job with the illustrations of basic principles www.nature.com/articles/s41...

New review paper from the influenza group @utrechtvirology.bsky.social together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com doi.org/10.1038/s442...

Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social www.biorxiv.org/content/10.1...

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

Last chance TODAY - to register and submit abstracts for #EMBObarrierTissues in Basel 🇨🇭🇨🇭🇨🇭! We've hit our registration goal 🥳, but there's always room for more. Join @maurogaya.bsky.social and me to explore the latest in lymphocyte and mucosal immunology. Details: meetings.embo.org/event/25-bar...

Very proud of Danica Besavilla, PhD student in the lab, receiving the Poster award at the #Antibodies & Complement meeting, taking place in Catania. She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses www.nature.com/articles/s44...

Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: www.biorxiv.org/content/10.1... 1/9

Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...

Postdoctoral position in Computational Biology open ! Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases More info 👇 : lnkd.in/dQZq55nv lnkd.in/d6sbw59P

The American Society for Microbiology is committed to ensuring that scientific research is conducted adhering to strict standards for biosafety and biosecurity, but pausing research is not the path forward. Read our statement: asm.org/press-releas...

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues

In @jem.org, Conlon, Huang, and Gerner show that immunization generates concentration gradients of antigens and #inflammation across interconnected chains of lymph nodes that regulate the magnitude and heterogeneity of adaptive immunity. rupress.org/jem/article/...

Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination @angelettilab.bsky.social www.pnas.org/doi/10.1073/...

Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue. The work has just been published in @pnas.org (1/N) www.pnas.org/doi/10.1073/...

Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection: www.biorxiv.org/content/10.1...

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

Very excited to share our new review in @embomolmed.org @embopress.org on human tonsil/adenoid-based immune organoid cultures for drug and vaccine testing in a human-first approach! With @maximilianmoll.bsky.social at @immunosens.bsky.social and @unibonn.bsky.social www.embopress.org/doi/full/10....

This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA. Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection www.nature.com/articles/s41...

Excited to share our first paper of 2025, just published in @naturecomms.bsky.social 🧪🦠 Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute. Short thread below 🧵 rdcu.be/d5JEL #ViroSky

As a first #ImmunoSky post, I’m excited to share our latest pre-print, by the fantastic Mitchell Zheng! www.biorxiv.org/content/10.1... Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. 🧵 1/9

Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem–specific human B cells www.science.org/doi/10.1126/...

Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection @cp-immunity.bsky.social www.cell.com/immunity/ful...

Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence www.cell.com/immunity/ful... @cp-immunity.bsky.social

@joelrc.bsky.social 's paper on differences between the seasonal H1N1 and H3N2 lineages in their relative capacity to antagonize IFN induction and signaling at the single cell level is out now in PLOS Pathogens: journals.plos.org/plospathogen...

Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.

It's an #immunology triple feature this week in #ScienceTranslationalMedicine! @science.org

I'm excited to share the first paper from our flu "human challenge" study at Emory University. 6/8 of those exposed became infected. We enumerated infectious virus and/or RNA in nasal swabs, saliva, respiratory particles, stool, environmental surfaces. journals.asm.org/doi/10.1128/...

📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...

To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick. We find that B cells take bites out of parasites to obtain antigens for presentation to T cells. www.biorxiv.org/content/10.1...

Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025

🌟 Exciting News! 🌟 The Society for Mucosal Immunology is now on Bluesky! Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬 👉 Find us here: socmucimm.org @mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity

Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!

Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."

🦠🧬🧫 Reminder that mBio publishes review articles and perspectives. If you have an idea in any area of microbiology or infection immunology, message me. No publication charge. Support Amer Soc Micro rather than a for-profit publisher! 📑💰 journals.asm.org/journal/mbio...

Very excited to share the most recent work from #theonlylabever out in @jexpmed.bsky.social We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis. Hope you will find this interesting: doi.org/10.1084/jem....

The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/

Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!