This was a lovely read

Had this been a 42-nucleotide ribozyme… Seriously impressive nonetheless, never thought this was possible.

Abstract submission and registration just opened 🤫 #spatial #biology

SanDiegoing #paraglider #blacksbeach

FITdb keeps growing with new #functionalscreens and viz features, now including human screen comparisons and figure-ready plot downloads. We are currently crunching the biggest perturb-seq dataset yet… stay tuned!

Kickstarting the 2026 Reina Lab retreat with a good dose of #nightscience courtesy of Dr. Wayne Beach, an expert (human) Conversation Analyst, under the premise - can we leverage human interaction analysis frameworks to think outside the box in cellular communication? … food for thought

The beneficial effects of vaccines in lowering dementia risk are bigger, better established, and occur for a wider range of vaccines than I had realized. Flu, tdap vax as well as shingles. Gift link: www.nytimes.com/2026/01/03/h...

I’ve been mentoring admissions + fellowship applications for ~6 years (through Científico Latino, Project SHORT, TechDev Academy, and as an NSF mentor via Harvard GSAS), and I finally formalized it into a clear coaching structure with options + pricing. www.yaelcourtney.com/coaching

Hill shenanigans 🎄 #paragliding

-16!! We made it out of Boston alive… jokes aside it was awesome seeing the students get a chance to share their progress in front of a fantastic crowd. #Immgenmaps

How could I miss this study earlier this year? This is wild, so cool. Cell-autonomous innate immunity by proteasome-derived defence peptides

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

Major new release of spatial data today - Take a peek using our #ImmGenMaps Portal or go for a deeper dive using #talktodata powered by BioTuring. New additions include bone marrow, adipose tissue (three different kinds), bladder…

#CancerImmuno speaker list is live!📢 Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research. Early Bird Deadline: 15 Jan 2026 👉 Click here to register: bit.ly/4qZVqmd #FusionImmunology #FusionCancerResearch

@larallbb.bsky.social and colleagues from @salkinstitute.bsky.social report a new #aging paradigm that links systemic infections and aging with astroctyte-dependent control of motor skills in mouse and humans. www.biorxiv.org/content/10.1...

According to the Colorectal Cancer Alliance, more than 50,000 people in the United States will die from colorectal #cancer this year. LJI Assistant Prof. Miguel Reina-Campos (@reinacampos.bsky.social) hopes to help change that statistic. bit.ly/3LJfvwK #CancerResearch #Immunology #Health #Medicine

Finally got to visit the birthplace of spatial biology to meet my heroes pushing the field at @ki.se, lovely campus full of wicked smart trainees - thanks for the invite @ejvillablanca.bsky.social

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

If Kathy Nguyen is ever your eye surgeon, you’ll be in good hands! This brilliant undergrad spent her summer training in LJI's Reina Lab (@reinacampos.bsky.social). Now she's poised to pursue a career in medical science: www.lji.org/blog/a-pivot... #SanDiego #medicine @ucsandiego.bsky.social

Maps have powered human discovery for centuries. At @immgen.bsky.social, we are creating the first spatial omics atlas of the mouse immune system **ImmGenMaps** to help connect the dots. Powered by Bioturing, we are now making these data available to all. Happy Exploring!

If you think I'm not alarmed, read this. www.theatlantic.com/newsletters/...

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is SMC (structural maintenance of chromosomes) protein 1A! 🧬🛠️ Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery. 📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social

#Spatialtranscriptomics breakthrough with RAEFISH - Impressive work

Hang in there

Important well-explained summary: “NIH has awarded nearly 3,000 fewer research project grants than it did the previous year”.

Link to HHMI preprint mandate hhmicdn.blob.core.windows.net/policies/Imm...

Forget the Turing test, will #AGI be able to pass the ultimate test? Embed Figures on a Microsoft Word. Seriously, @billgates.bsky.social - what is going to take?

Impressive list of breakthroughs underlie Colossal’s #deextinction dodo program, just proves injecting (lots) of $ on a problem does have a return… certainly an interesting model

Long-term high-altitude exposure adaption drives: 🔼 neutrophil maturation, NK cell killing, DC responsiveness, steroid hormone synthesis, UFA & AA metabolism 🔻plasmablast maturation, T cell response via enhanced aerobic oxidation efficiency papers.ssrn.com/sol3/papers.... preprint

This is a hack of epic proportions if true, and I am sure it has an equally interesting back story I hope to hear one day

Violante's project at @lji.org seeks to unlock prostate cancer immunotherapies - take a peek by yourself @cancerresearchinst.bsky.social

The closest evidence for #extraterrestrial signs of (past) life was revealed today in Nature by Hurowitz et al. This is incredibly exciting.

🗓️Join us for the 4th Stanford.Berkeley.UCSF Next Generation Faculty Symposium on 9/10/25! We highlight the work of 18 exceptional early-career scientists across biomedical sciences. Register and more information below: www.berkeleystanfordnextgensymposium.com/speakersalumni

If you need a pick me up today, this might do it! love hearing mRNA discussed so profusely! wait until they hear about spatial :D

A federal judge in Boston said she found it "difficult to conclude anything other than that [the Trump administration] used antisemitism as a smokescreen for a targeted, ideologically-motivated assault on this country's premier universities, and did so in a way that runs afoul of [federal law]."

Our paper made the cover of Nature Immunology’s September issue! 🎉 Aren’t dendritic cells beautiful? 😍 SEM shows pDCs as they switch identity into cDC2-like cells. Congrats to the whole team! 👏 🔗 www.nature.com/ni/volumes/2...

Lofty goals for this week | Blossom Valley

A stunning first look at the viruses inside us by the Saphire lab

Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social

Current and former members of the NIH community have valuable personal perspectives to share about the devastation that is happening to US biomedical research, our federal agencies, and our democracy. This starter pack is a great way to hear what they have to say and what you can do about it. 🧪🧬🧠🥼🇺🇸

Data access coming up soon... stay tuned!

Be in a place where they value your ideas | The #SPARK program ignites high risk high reward projects for rising stars at @lji.org | So proud of all the finalists including our very own Dr. Olivari

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

cell typing is an unsolved and unexpectedly difficult bottleneck that is critical for single cell spatial analysis | a handy resource by @10xgenomics.bsky.social

Nothing seems to work for #advanced #prostatecancer, luckily Violante is thinking outside the box to unlock immunotherapies in this pesky organ @lji.org - We won't know unless we try it!

Brand New #FITdb (fitdb.lji.org) tool now LIVE! Do you have a list of genes? You can use "Compare My Geneset" to test if these are overly-represented among functional regulators of T cells across more than 60 conditions! @lji.org supported and developed by Kevin Kim, Xinjian Cen and Harrison Ma.

A heads up for trainees looking to get their feet wet on bioinformatics > "Introduction to Computational Immunology Course" from @aai.org is worth checking out