Why does the cerebellum age earlier than other brain regions? Why are cerebellar astrocytes so profoundly altered in advanced age? How do these changes affect motor coordination? Check out my postdoc work here: www.biorxiv.org/content/10.1...

Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke. www.sciencedirect.com/science/arti...

This is the way www.nytimes.com/2025/10/10/u...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems www.nytimes.com/2025/10/06/h...

The courts aren’t falling for Trump’s chaos They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab I explain on @velshimsnbc.bsky.social👇

🔬 New preprint out! Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches. 📄 www.biorxiv.org/content/10.1... #scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social

I am thrilled to be attending Cytokines2025. See you in beautiful Seattle @cytokinesociety.bsky.social signals.cytokinesociety.org/2025/06/30/n...

Repost if you're planning to go.

www.pnas.org/doi/10.1073/... @trevergreene.bsky.social

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out! gleichmanlab.com

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...

I'll be talking about some of this at the rally at UCSD tomorrow, thanks for having me!

Very interesting review by @neuronoeker.bsky.social et al aging-longevity.org.ua/journal-desc...

Important reference for anyone planning to Stand Up for Science this week.

Looks like tomorrow will bring votes on a Republican plan to fund tax cuts for the rich by slashing Medicaid. So this is a great time to contact your Member of Congress.

Thank you @thetransmitter.bsky.social for bringing attention to this.

Yes

JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants. storage.courtlistener.com/recap/gov.us...

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

USA Capitol Switchboard (202) 224-3121 #resist

🚨New paper alert! 🚨 Our latest work in @cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/arti...

New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe #MucosalImmunology #TumorImmunology

How do T cells find the proper instructions to navigate tissues? In the Goldrath Lab @ucsdhealthsci.bsky.social, Amir Ferry mapped it out play-by-play. Potentiating these interactions strengthens the immunity cycle and enhances tumor control 1/n

Spatial omics rides again, this time determining how immune CD8 T cells by location in the gut have different roles, such as killing function in the villus and backup reinforcements in the crypts www.nature.com/articles/s41... Good Explainer www.lji.org/news-events/... @alleninstitute.bsky.social

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation. 🔗 www.nature.com/articles/s41.... @ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10

Beautiful study by @reinacampos.bsky.social @amonell.bsky.social @heeg.io Ananda Goldrath on the temporal and anatomical organization of Tcell memory. Tour de force spatial transcriptomics, computational methods, in vivo perturbation, spatial regulators and much more. www.nature.com/articles/s41...

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍 I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.

'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.' #Immunology #Neuroimmunology

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

Are you interested in doing research at the cutting edge of immunology? The Reina Lab at @ljiresearch.bsky.social applies innovative, multiomics approaches to understanding how the response to infections and cancers is deployed, regulated & organized within our body. Check out this job posting:

Astrocytes shape neuronal circuits, but their role in aging remains unclear. How do they change with age? What promotes aging in astrocytes, and how do they affect brain health 🧠✨? Thanks to @cp-neuron.bsky.social , my fabulous mentor Nicola J Allen & reviewers authors.elsevier.com/c/1kPEa3BtfH...

To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen. We hope you enjoy every single piece of it as much as we do! www.cell.com/neuron/current

#Astrocytes are the brain’s puppet masters - controlling development, repair and function of neural circuits - this key review by @larallbb.bsky.social and Nicola Allen from @salkinstitute.bsky.social in @cellpress.bsky.social summarize their critical role in #aging

A great study about how ageing affects gene expression in mice. TLDR: Biggest changes occur in neuronal and immunity genes. www.nature.com/articles/s41...

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence www.cell.com/immunity/ful... @cp-immunity.bsky.social