Susan Kaech, PhD, has been selected to be the new EVP of our Immunology moonshot. She currently leads the @salkinstitute.bsky.social NOMIS Center for Immunobiology & Microbial Pathogenesis. 🔗 alleninstitute.org/news/susan-k... #Immunology #CellBio #ImmunoBio

So proud to be a co-author on this study and absolutely loved the beautiful thread by @marionpepper.bsky.social — high recommended 👇

@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social www.biorxiv.org/content/10.1...

More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!

Very impressive paper by the Heeg and Goldrath labs using spatial transcriptomics to define CD8 Trm biology in the intestine in mice and humans. Congrats to @reinacampos.bsky.social and co-authors. #ImmunoSky

📢 Join our team at @alleninstitute.bsky.social! We're hiring a Bioinformatics Scientist II for spatial transcriptomics in immunology. Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team! Learn more: alleninstitute.org/careers/jobs...

Spatial omics rides again, this time determining how immune CD8 T cells by location in the gut have different roles, such as killing function in the villus and backup reinforcements in the crypts www.nature.com/articles/s41... Good Explainer www.lji.org/news-events/... @alleninstitute.bsky.social

New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe #MucosalImmunology #TumorImmunology

When your gut is under attack, the immune system is activated. Like any good army, the roles of each cellular soldier depends on their location. 🧵 📸 Elena Lin/ @ucsdhealthsci.bsky.social #ImmunoSky

Beautiful thread on how tissue-resident T cells organize in the gut post-infection from my co-conspirator @reinacampos.bsky.social. Our spatial multi-omics work revealed unexpected complexity in immune system architecture. Think less checkers, more 4D chess 🧬🔬

New in @nature.com — LJI's @reinacampos.bsky.social and colleagues at @ucsdhealthsci.bsky.social and @alleninstitute.bsky.social track the amazing journey of T cells in the gut. “For the first time, we were able to capture the formation of immunological memory in space and time." bit.ly/40Tnlt7

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation. 🔗 www.nature.com/articles/s41.... @ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10