Required reading for cell biologists to get a sense of basic statistical principles! www.nature.com/articles/s41...

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

🧵1/ 🚨 Our new paper is out! We used high-content morphological profiling in human iPSC-derived dopaminergic neurons to uncover a neuroprotective mechanism in Parkinson’s disease (PD): mild mitochondrial uncoupling. 🔗 doi.org/10.1038/s415...

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...

... and a few minutes ago our Chart-Checklist came out in @natcellbio.nature.com 🥳🎉 Gift link for #TCTeAC: rdcu.be/eqPpi www.nature.com/articles/s41...

Elon Musk wanted to buy Wikipedia so that he could determine our society’s collective view of truth. He couldn’t, so he created grok. Do not let these machines be arbiters of truth. It is abundantly clear that they are being used to push absurd far-right conspiracies.

Wow, just implemented the new Cellpose-SAM from @computingnature.bsky.social in NimbusImage and it's *awesome*! Give it a try! nimbusimage.com

tl;dr: Python or R or both www.nature.com/articles/d41...

I explored whether scientific literature provides evidence of AI use in research publications. I analyzed the use of certain words before & after 2022 using PubMed, focusing on terms commonly used by ChatGPT (e.g., "delve") & standard scientific phrases ("in this study", "our results"). 1/n

Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action go.nature.com/4a9lMs8 rdcu.be/egMl1

Must-read to review for everyone who is puzzled by and maybe even tries to understand microglia plasticity.

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

Next time you are out of breath during a run, try switching of this annoying STOP codon in your KEAP1 gene. Or alternatively, accept that you will never run as long and fast as a horse.

By contrast, the absence of marathon running (or sports in general) leads probably to irreversible changes in the brain. * hypothesises a marathon runner

Not AI, but CRISPR A&I is what it takes to understand gene regulation.

Nice example of how to be friendly, positive, and very determined at the same time.

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

Something I learned today: Although human mitochondria contain more than 1100 proteins, only 13 of them are encoded by mtDNA.

Full of interesting stuff if you're into translation. www.science.org/doi/10.1126/...

"This isn’t about politics — it’s about the systematic dismantling of the very infrastructure that made American innovation possible."

Form follows function? Not so sure about that. But morphology and calcium fluxes do not seem to follow the transcriptome. www.nature.com/articles/s41...

Pubmed #Science

"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models +1 www.cell.com/cell-systems...

Interesting paper about how the integrated stress response induces cell death independent from a specific stress stimulus. Also featuring some nice applications of ISRIB, a stress response inhibitor. @altoslabs.bsky.social www.nature.com/articles/s41...

Evidence that C9orf72 microglia have a cell-autonomous pro-inflammatory phenotype (NLRP3) that contributes to non-cell autonomous mechanisms of motor neuron degeneration in ALS doi.org/10.1101/2025...

🖊️AI for health: the impossible necessity of unbiased data Is unbiased data important to build health AI? Yes! Can there be unbiased data? No! Building health on biased data discriminates The notion of bias depends on the intended use: gael-varoquaux.info/science/ai-f...

Interesting article. Many links to lysosomal biology and insights on how loss of function mutations in neurodegenerative disease are tackled by various companies.

🚨Job alert: We're hiring a Data Scientist (Image Analysis) to join our Facility for Advanced Imaging & Microscopy. The facility provides cutting-edge light and electron microscopy, high-content screening, image analysis and spatial-transcriptomics services. Apply at: www.fmi.ch/education-ca...

Nice! #RNAdecay #mRNAdecay #QualityControl #Cytoplasm #RNAsky #RNA www.nature.com/articles/s41...

We published an updated version of our pre-print describing morphological profiling and compound screening in human dopaminergic neurons on @biorxiv-neursci.bsky.social doi.org/10.1101/2024...

This is really a fantastic blog post by @brooksleitner.bsky.social about the potential of AI for neuropsychiatric drug development on multiple levels. Brooks also warns that everything needs to be applicable to the human brain. Massive compute based on in vitro reductionist data might not fix it.

Here is a "starter pack" to quickly find/follow other accounts interested in #SHANK3 #Phelan-McDermid syndrome. Contact Ana Mingorance @cnsdrughunter.bsky.social if you would like to be included in the starter pack! go.bsky.app/5LKoxop

Another link between viral infection and neurodegenerative disease. Interesting mechanism related to the nuclear pore complex. biorxiv.org/content/earl...

Great organoids paper. If you want to freeze and recover viable organoids, without them exploding on thaw, there is a way. DM me. 🧪

Some clinical trial results to look forward to this year:

Let's see at year end if it worked. It would be a great advance, but the constraints of reality are harsh. But then again he managed to predict protein 3D structures from sequences... on.ft.com/4auJzVu

Great read! But it's still a long way. 1) Some of these associations have been observed before (i.e ibuprofen) & focused clinical to trials could not validate the proposed effect. 2) Different incentive models for clin trials are needed, drug repurposing is financially not interesting for pharma.

"Unless you experience the unpleasant symptoms of being wrong, your brain will never revise its models. Before your neurons can succeed, they must repeatedly fail. There are no shortcuts for this painstaking process."

The blood-brain barrier can prevent therapeutic drugs from reaching the brain. Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6

Great to be in San Francisco representing Ksilink during the JP Morgan Healthcare week. Looking forward to lots of learning experiences. If you have questions about neuronal drug discovery models and AI for data analysis, just reach out! #JPM #JPM25

A map of protein organization in the cell. More indications that (RNA) expression data alone is not enough: Some co-colocalized proteins showed minimal overlap with proteins that are regulated at the level of RNA expression or absolute protein abundance. www.cell.com/cell/fulltex...

Two studies showing how aberrant splicing might be connected to neurological disease (here: Huntington's disease and Autism). Very exciting from a drug dev perspective! First study: rdcu.be/d5SSp (METTL3 related to exon skipping) and the second study: rdcu.be/d5SSQ (microexon linked to CPEB4)

More on post-transcriptional & neuroinflammation regulation in Parkinson's disease. aSyn aggregates trigger inflammatory responses and neuronal toxicity through dysregulated ADAR1-mediated RNA editing in astrocytes. In vitro & post-mortem human PD brain evidence. www.biorxiv.org/content/10.1...

Secretly I always knew that translation regulation is THE most important regulative layer in biology 😉

For the first time the @fda.gov proposes guidelines for the use of AI during drug development. The actual document can be downloaded here: www.fda.gov/media/184830... #AI #drugdiscovery www.fda.gov/news-events/...

Very important study for everyone working in neurodevelopment and/or with microglia. www.nature.com/articles/s41...

Photons, probes, and proteins. Great overview about which aspects to consider when planning a fluorescent imaging experiment. focalplane.biologists.com/2024/12/14/p...

Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...