Jeremy Hollis
@jeremyahollis.bsky.social
📤 66
📥 69
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of the arts and sciences jeremyhollisdesigns.com campbelllab.org
pinned post!
We have some genetic sleuth work to share with you! What started as a rotation project turned into nothing short of an amazing collaboration between 4 labs in the zoo that is
@basicsci.fredhutch.org
. We found an essential histone chaperone long thought to be missing in most animals 🕵️♂️
bit.ly/4uf8sxz
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https://bit.ly/4uf8sxz
21 days ago
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We have some genetic sleuth work to share with you! What started as a rotation project turned into nothing short of an amazing collaboration between 4 labs in the zoo that is
@basicsci.fredhutch.org
. We found an essential histone chaperone long thought to be missing in most animals 🕵️♂️
bit.ly/4uf8sxz
loading . . .
https://bit.ly/4uf8sxz
21 days ago
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reposted by
Jeremy Hollis
Fred Hutch
24 days ago
Published today in Science Immunology:
@sriv4000.bsky.social
and team find a new way to give
#CARTcells
their own portable pit crew, allowing them to rejuvenate on the go and transforms them into a type of T cell that can support long-term immune responses against tumors.
https://bit.ly/3NiSged
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Giving CAR T cells a portable pit crew
Fred Hutch Cancer Center scientists have developed an experimental strategy to give genetically engineered CAR T cells help they'd normally find within lymph nodes -- but on the go, within the tumor. The new genetic tweaks rewired CAR T cells to respond...
https://bit.ly/3NiSged
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reposted by
Jeremy Hollis
25 days ago
Our story on the evolution of colistin resistance is just out on
@plosbiology.org
(
journals.plos.org/plosbiology/...
Evolution doesn’t happen in isolation. We show that competing fungi can rewire the evolutionary trajectory of colistin resistance in P. aeruginosa. Great teamwork with the Ernst lab
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Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs
Bacterial resistance to the vital last-resort antibiotic colistin is an increasing challenge. This study shows that magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher l...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003673
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reposted by
Jeremy Hollis
Irini Topalidou
about 1 month ago
Big thanks to Aakanksha
@singhvilabglia.bsky.social
for the nomination, to J. Bai and
@nlehrbach.bsky.social
for supporting it, to A. Calixto, S. Karimzadegan, P. Gurung, J. Cattin-Ortola, M. Crawford, for their supportive letters and to all my mentees for making this job colorful and meaningful ♥️
add a skeleton here at some point
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reposted by
Jeremy Hollis
Tim Yu
2 months ago
In new work by
@jahn0.bsky.social
and I in
@jbloomlab.bsky.social
, we investigate how sequence constraints differ across influenza HA subtypes. We find ~50% of sites in HA display substantially different amino-acid preferences across H3, H5, and H7.
doi.org/10.64898/202...
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Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures
Hemagglutinins (HA) from different influenza A virus subtypes share as little as ∼40% amino acid identity, yet their protein structure and cell entry function are highly conserved. Here we examine the extent that sequence constraints on HA differ across three subtypes. To do this, we first use pseudovirus deep mutational scanning to measure how all amino-acid mutations to an H7 HA affect its cell entry function. We then compare these new measurements to previously described measurements of how all mutations to H3 and H5 HAs affect cell entry function. We find that ∼50% of HA sites display substantially diverged preferences for different amino acids across the HA subtypes. The sites with the most divergent amino-acid preferences tend to be buried and have biochemically distinct wildtype amino acids in the different HA subtypes. We provide an example of how rewiring the interactions among contacting residues has dramatically shifted which amino acids are tolerated at specific sites. Overall, our results show how proteins with the same structure and function can become subject to very different site-specific evolutionary constraints as their sequences diverge. ### Competing Interest Statement JDB consults for Apriori Bio, Invivyd, Pfizer, GSK, and the Vaccine Company. JDB and BD are inventors on Fred Hutch licensed patents related to the deep mutational scanning of viral proteins. National Institute of Allergy and Infectious Diseases, R01AI165821, 75N93021C00015 U.S. National Science Foundation, DGE-2140004 Howard Hughes Medical Institute, https://ror.org/006w34k90
https://doi.org/10.64898/2026.01.05.697808
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A massive, heartfelt thanks to
@pauligroup.bsky.social
and
@svenklumpe.bsky.social
at the
@impvienna.bsky.social
for being the bests hosts a visitor could ask for. Happy holidays!
3 months ago
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reposted by
Jeremy Hollis
Harmit Singh Malik
4 months ago
@pravrutharaman.bsky.social
got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here:
www.biorxiv.org/content/10.6...
We hope these analyses will help spur more analyses in this very cool gene! 1/
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Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
https://www.biorxiv.org/content/10.64898/2025.12.12.693809v1?ct=
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reposted by
Jeremy Hollis
Harmit Singh Malik
4 months ago
Very proud of our lab manager, Aida de la Cruz, for winning the Nancy Hutchinson mentoring award (
www.fredhutch.org/en/education...
) based on her mentees' nominations.
@fredhutch.org
@basicsci.fredhutch.org
Internal news:
centernet.fredhutch.org/n/2025/12/sp...
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reposted by
Jeremy Hollis
Fred Hutch Basic Sciences Division
5 months ago
So many phenomenal pumpkins at this year’s carving contest! Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the
@melodygcampbell.bsky.social
Lab for most artistic and the
@harmitmalik.bsky.social
Lab for most scientific!
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So excited to see the first part of my thesis work with
@harmitmalik.bsky.social
and
@melodygcampbell.bsky.social
in print!
www.science.org/doi/10.1126/...
We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
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Molecular exaptation by the integrin αI domain
An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.
https://www.science.org/doi/10.1126/sciadv.adx9567
7 months ago
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reposted by
Jeremy Hollis
9 months ago
I’m thrilled to announce the launch of the Evolution of Chromosomes and Genomes (ECG) Lab at the Institute of Molecular Biology, Academia Sinica, Taiwan. Our lab website is now live—come check it out!
sites.google.com/view/ecg-lab...
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ECG LAB
"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...
https://sites.google.com/view/ecg-lab/home
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reposted by
Jeremy Hollis
9 months ago
Exciting news! I am launching the Lab of Polymicrobial Interaction & Evolution at IPMB at Academia Sinica (
ipmb.sinica.edu.tw/en
)! 🎉Our brand-new website is live: (
www.labofpie.org
). Check the lab of PIE out!!🥧🎈
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IPMB | 中央研究院植物暨微生物學研究所
https://ipmb.sinica.edu.tw/en
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reposted by
Jeremy Hollis
Melody Campbell
about 1 year ago
Congrats to Jeremy Hollis on receiving the Weintraub Award! A well-deserved recognition to a person who exemplifies (and resembles?) Hal.
add a skeleton here at some point
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