The 2025 Basic Sciences retreat continues today with talks from division faculty. Can’t wait to meet the first-year postbacs and @mcbseattle.bsky.social students. Excited for another great day of science!

The 2025 Basic Sciences retreat kicks off today at 2:00 p.m. with the main poster session in the Behnke Suites in Arnold Building. Can’t wait to hear about all the latest research happening in the division!

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Changkun Hu, PhD, is our featured fellow! Dr. Hu uses in vitro reconstitution and TIRF microscopy (😍😍) to investigate the kinetochore, a protein complex that's required for the proper segregation of chromosomes. 1/

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

In new study led by Xiaohui Ju, we define how mutations to Chikungunya virus envelope proteins affect entry in human vs mosquito cells. Sheds light on functional constraints & enables us to make loss-of-tropism mutants, which could be of use for vaccines. www.biorxiv.org/content/10.1...

Drs. Steve Hahn and Lakshmi Mahendrawada sit down with the Double-stranded Podcast. Check out a great conversation and learn about their recent @nature.com paper that’s rewriting our understanding of transcription factors: youtu.be/lXgdvmveA_k?...

Preparing to say goodbye to two outstanding scientists from the lab: Ching-Ho Chang (‪@ching-hochang.bsky.social‬) and Yu-Ying Phoebe Hsieh (‪@hsiehyp.bsky.social‬) who are both leaving the lab at the end of the month to start their own independent labs at the prestigious Academia Sinica in Taipei

In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. www.biorxiv.org/content/10.1...

Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management. If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job

Wanted to flag this interesting study led by our collaborators @kinglabipd.bsky.social suggesting that at least in some contexts, the immunogenicity of H5 influenza vaccines can be improved by mutations that stabilize the HA protein.

Final version of this paper is published in Journal of Virology: journals.asm.org/doi/10.1128/... If you are interested in implementing RSV pseudovirus neutralization assays, the plasmids are now available in AddGene (www.addgene.org/browse/artic...) and we are happy to share the 293T-TIM1 cells.

During his 36-year career at Fred Hutch, @memerman.bsky.social made fundamental discoveries about HIV, co-founded the field of paleovirology and mentored generations of scientists. bit.ly/4nMqOmr @hutchbasicsci.bsky.social

"Signals, forces and cells: Force sensing in epithelial tissues" We’re excited to have Dr. Jennifer Zallen joining us from @mskcancercenter.bsky.social for a special guest seminar. For all our @FredHutch.bsky.social colleagues, don’t miss a great talk today at noon!

Staff, faculty, providers and furry friends 🐶 came out to celebrate Fred Hutch's 50th Anniversary at the South Lake Union campus. #fredhutch #fh50 #cancer #cancerresearch #cancertreatment #seattle

Scenes from the 51st @seattlepride.bsky.social! #fredhutch

For all our @FredHutch.bsky.social colleagues, don’t miss a special talk today at noon hosted by the Fred Hutch Chromatin Club. We’re excited to have Dr. Zhiguo Zhang joining us from @columbiamed.bsky.social to share his latest discoveries on chromatin replication.

Grateful to the lab for celebrating 25 years and to @hutchbasicsci.bsky.social for being such a great place to do science!

Fred Hutch joins the nation in commemorating Juneteenth National Independence Day, a time to honor the emancipation of enslaved African Americans in the United States. We celebrate the resilience and strength of those early Americans who never gave up hope during uncertain times.

Celebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!

Congratulations to these exceptional early-career scientists!

Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)

From First Hill to South Lake Union, take a look at how the Fred Hutch campus has changed over the last 50 years. Learn more: www.fredhutch.org/en/news/cent...

Congratulations to @lapointelab.bsky.social‬ on being named a 2025 Rita Allen Foundation Scholar! This award will support his critical research @FredHutch.bsky.social studying how healthy cells control protein production and how this control breaks down in disease.

We’re hiring two research administrators! Join us and help support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social. Learn more and apply:

Happening TODAY - Manuel Rosero’s dissertation defense! Title: Thermosensory Neurons Mediate Tactile-Dependent Locomotion Modulation in C. elegans Lab: Bai Lab, FH When: Friday, June 6, 2pm PDT Where: FH Pelton Auditorium & Zoom (email [email protected] for link)

Research administrators are crucial to our mission, helping support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social. We’re hiring two research administrators and would love for you to join us:

My Keynote Talk at the CSHL 50th annual meeting on Retroviruses is now online: leadingstrand.cshl.edu/Keynote/Medi... Some more general parts such as ~ the 8'30" mark with the "What I learned from Howard Temin" slide and ~ the 40' mark with the "What is important to me in science" section.

🎉 Huge congratulations to Dr. Meghan Koch on being named a @bwfund.bsky.social‬ 2025 Investigator in the Pathogenesis of Infectious Disease! The award supports her groundbreaking research @FredHutch exploring how maternal-offspring interactions shape neonatal health.

In new study led by @timyu.bsky.social, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints www.biorxiv.org/content/10.1...

"Unfolding RNA structure for its translation in cancer & therapy” We’re excited to have @ruggerolab.bsky.social joining us from @ucsfurology.bsky.social to speak at today’s Current Biology Seminar. For all our @FredHutch.bsky.social colleagues, don’t miss the final talk of the series!

Two great talks lined up for the final Friday Afternoon Seminars of the season! For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

"Microbiota-Immune interactions that promote health" We’re excited to have Dr. June Round joining us from the University of Utah Department of Pathology to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk!

We’re excited to have Alex Kaiser from the Stoddard Lab and Jae Heun Cheung from Human Biology’s @davidmacphersonlab.bsky.social sharing their latest research at Friday Afternoon Seminars. For everyone @FredHutch.bsky.social, don’t miss two fantastic talks today at 4:00!

Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends www.science.org/doi/10.1126/... Rechel is now back in medical school training to become a kickass physician-scientist

"Unsupervised learning for genomics to decipher dynamics of 3D genome organization and gene regulatory networks” We’re excited for a great talk from @sroyyors.bsky.social at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss it at noon in Pelton Auditorium.

We have a Basic Sciences double feature at Friday Afternoon Seminars! For all our @FredHutch.bsky.social colleagues, join us at 4:00 in Pelton to hear two great talks from Rose Bosire in the Adeyemi Lab and Sarah Leichter in the Henikoff Lab!

"Nutritional Inheritance in Development and Disease" We’re excited to have Dr. Monica Dus joining us from @umich.edu to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk at noon!

Excited for two great speakers at Friday Afternoon Seminars! For everyone @FredHutch.bsky.social, join us at 4:00 in Pelton to hear Erin Ramsey from the Eisenman Lab and Nick Salisbury from Human Biology’s Galloway Lab share their latest research!

Two recently published papers from postdocs in the labs of Drs. Trevor Bedford and @jbloomlab.bsky.social, showcase new tools that provide researchers traction to make the mountain of data amassed in studying SARS-CoV-2 and its many variants more manageable. 1/3 www.fredhutch.org/en/news/cent...

We want to thank the division’s research administrators for their immeasurable impact on Basic Sciences @FredHutch.bsky.social. From keeping labs supplied, managing funding, and resolving problems big and small, we’re grateful for what they do every day. #AdministrativeProfessionalsDay

"Understanding the Sources of Regenerative Capacity in Animals" Dr. Alejandro Sánchez Alvarado (@planaria1.bsky.social) is speaking at today’s Current Biology Seminar, and we’re excited for a fascinating talk! For all our @FredHutch.bsky.social colleagues join us at noon in Pelton.

We’re excited to have Anuradha Venkatramani from the Hahn Lab and Abby Parrish from Human Biology’s Holland Lab sharing their latest research at Friday Afternoon Seminars. For everyone @FredHutch.bsky.social, don’t miss two fantastic talks today at 4:00!

Interested in postdoc opportunities in Seattle, WA? Join us May 6th for Seattle DROP, a virtual event about biomedical research in Seattle. Hear from recruiting faculty, finding the right mentor and enjoy lunch on us via a delivery voucher within the US! Registration: tinyurl.com/seattledrop25

Terrific findings from Steve Hahn's lab in @hutchbasicsci.bsky.social!

In new work published today in @nature.com, researchers in @hutchbasicsci.bsky.social discover that most transcription factors in budding yeast don’t follow the textbook example of binding close to the genes they regulate. www.fredhutch.org/en/news/cent...

"Crafting Neural Messages: The Symphony of Force, Form, and Function" We’re excited to have Dr. Shigeki Watanabe joining us from Johns Hopkins School of Medicine to share his latest discoveries at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss it!

We’re excited to have Mitsutoshi Nakamura from the Parkhurst Lab and Andrew Snyder from Human Biology’s Srivastava Lab sharing their latest research at Friday Afternoon Seminars. For all our @FredHutch.bsky.social colleagues, don’t miss two great talks today at 4:00 in Pelton.

"How physiological temperature drives ligand recognition and channel gating" We’re excited to have Dr. Juan Du joining us from Northwestern University to share her latest discoveries at today’s Current Biology Seminar at noon! For all our @FredHutch.bsky.social colleagues, don’t miss it!

We are excited to announce the 52nd Maine Biological and Medical Sciences Symposium (#MBMSS) at the MDI Bio Lab, featuring keynote speaker @harmitmalik.bsky.social, Professor and Associate Director @hutchbasicsci.bsky.social. Don't miss out — register now! 🧪 🤝 🧬 🍎 👩‍🔬 #standwithscience