Excited for two great speakers at Friday Afternoon Seminars! For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!

Join us for Darren Mallett’s dissertation defense! Title: Uncovering the mechanisms that control unattached kinetochore clustering Lab: Biggins Lab, FH When: Friday, November 14, 10 a.m. PST Where: Fred Hutch Pelton Auditorium (Weintraub Building)

Congrats to Steven Henikoff, PhD, of @basicsci.fredhutch.org on receiving the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research! @brandeisuniversity.bsky.social recognized Henikoff with this prestigious award for his innovative studies on gene expression.

Today we celebrated Dr. Steve Henikoff receiving the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. Dr. Henikoff will formally receive the award and present a lecture on his work next April @brandeisuniversity.bsky.social. www.brandeis.edu/stories/2025...

Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research.

@jhigginswriter.bsky.social wrote an article about my lab and our frog 🐸 at the Hutch! Thank you!

"Foundation models for 3D genome architecture and tandem mass spectra" We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!

When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.

Dr. @yarimura.bsky.social brings frogs back to Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. bit.ly/3J8S5Ae

More pictures of the brilliance that is (lab manager) Aida de la Cruz with her creation.

So many phenomenal pumpkins at this year’s carving contest! Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!

The 2025 Pumpkin Carving Contest Kicks off at 4pm today! Can’t wait to see everyone and their amazing pumpkins!

In a study published in @science.org, Fred Hutch immunologist Meghan Koch, PhD, describes how breastmilk helps newborn mice develop immune tolerance to gut microbes and new foods, revealing a key mechanism that kicks in during the first week of life. https://bit.ly/4ogmQ53

It's a Basic Sciences double feature for Friday Afternoon Seminars! Excited to learn about the latest discoveries from Xiaohui Ju in the @jbloomlab.bsky.social and Matthew Chan in the @rasilab.bsky.social and @melodygcampbell.bsky.social Lab. See everyone at 4pm in Pelton for two great talks!

"Decoding the autoantibody reactome." We’re excited to have @aaronmring.bsky.social joining us from the Translational Science and Therapeutics Division to share his latest research at today’s Current Biology Seminar! For all our @FredHutch.org colleagues, don’t miss a great talk at noon!

Friday Afternoon Seminars are back! Kicking things off are @pravrutharaman.bsky.social from the @harmitmalik.bsky.social Lab and @christianloyo.bsky.social from Human Biology’s Salama Lab. Can’t wait to see everyone today at 4:00 pm in Pelton for two great talks!

For this Current Biology Seminar series, we’re hosting local luminaries from the pacific northwest. For the first talk of the series, we’re excited to have Dr. Eric Holland speaking today at noon in Pelton. For all our @FredHutch.org colleagues, don’t miss a great talk!

The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...

Congrats to Rina Hirano, postdoc in the Tsukiyama Lab, for receiving the Japan Society for the Promotion of Science's Overseas Research Fellowship in support of excellent young Japanese scientists working abroad! The fellowship helps further her research on how cells go in and out of quiescence.

It's National Research Administrator Day! On behalf of everyone in the division, we thank our research administrators for their vital role in advancing Basic Sciences. From managing labs and funding to resolving problems big and small, our division's success is thanks to their many contributions.

Fred Hutch immunologist Dr. Meghan Koch discovers a biological mechanism sprung in the first week of life that trains a mouse pup’s immune system to tolerate harmless gut bugs and new foods — insights that could lead to potential therapies for food allergies in newborns and infants.

This year, Fred Hutch Cancer Center turned the big 5-0 and celebrated all year long with stories highlighting the people and moments that have truly defined the organization. 👉 https://bit.ly/4nengsC #FH50

The 2025 Basic Sciences retreat continues today with talks from division faculty. Can’t wait to meet the first-year postbacs and @mcbseattle.bsky.social students. Excited for another great day of science!

The 2025 Basic Sciences retreat kicks off today at 2:00 p.m. with the main poster session in the Behnke Suites in Arnold Building. Can’t wait to hear about all the latest research happening in the division!

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Changkun Hu, PhD, is our featured fellow! Dr. Hu uses in vitro reconstitution and TIRF microscopy (😍😍) to investigate the kinetochore, a protein complex that's required for the proper segregation of chromosomes. 1/

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

In new study led by Xiaohui Ju, we define how mutations to Chikungunya virus envelope proteins affect entry in human vs mosquito cells. Sheds light on functional constraints & enables us to make loss-of-tropism mutants, which could be of use for vaccines. www.biorxiv.org/content/10.1...

Drs. Steve Hahn and Lakshmi Mahendrawada sit down with the Double-stranded Podcast. Check out a great conversation and learn about their recent @nature.com paper that’s rewriting our understanding of transcription factors: youtu.be/lXgdvmveA_k?...

Preparing to say goodbye to two outstanding scientists from the lab: Ching-Ho Chang (‪@ching-hochang.bsky.social‬) and Yu-Ying Phoebe Hsieh (‪@hsiehyp.bsky.social‬) who are both leaving the lab at the end of the month to start their own independent labs at the prestigious Academia Sinica in Taipei

In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. www.biorxiv.org/content/10.1...

Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management. If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job

Wanted to flag this interesting study led by our collaborators @kinglabipd.bsky.social suggesting that at least in some contexts, the immunogenicity of H5 influenza vaccines can be improved by mutations that stabilize the HA protein.

Final version of this paper is published in Journal of Virology: journals.asm.org/doi/10.1128/... If you are interested in implementing RSV pseudovirus neutralization assays, the plasmids are now available in AddGene (www.addgene.org/browse/artic...) and we are happy to share the 293T-TIM1 cells.

During his 36-year career at Fred Hutch, @memerman.bsky.social made fundamental discoveries about HIV, co-founded the field of paleovirology and mentored generations of scientists. bit.ly/4nMqOmr @hutchbasicsci.bsky.social

"Signals, forces and cells: Force sensing in epithelial tissues" We’re excited to have Dr. Jennifer Zallen joining us from @mskcancercenter.bsky.social for a special guest seminar. For all our @FredHutch.bsky.social colleagues, don’t miss a great talk today at noon!

Staff, faculty, providers and furry friends 🐶 came out to celebrate Fred Hutch's 50th Anniversary at the South Lake Union campus. #fredhutch #fh50 #cancer #cancerresearch #cancertreatment #seattle

Scenes from the 51st @seattlepride.bsky.social! #fredhutch

For all our @FredHutch.bsky.social colleagues, don’t miss a special talk today at noon hosted by the Fred Hutch Chromatin Club. We’re excited to have Dr. Zhiguo Zhang joining us from @columbiamed.bsky.social to share his latest discoveries on chromatin replication.

Grateful to the lab for celebrating 25 years and to @hutchbasicsci.bsky.social for being such a great place to do science!

Fred Hutch joins the nation in commemorating Juneteenth National Independence Day, a time to honor the emancipation of enslaved African Americans in the United States. We celebrate the resilience and strength of those early Americans who never gave up hope during uncertain times.

Celebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!

Congratulations to these exceptional early-career scientists!

Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)

From First Hill to South Lake Union, take a look at how the Fred Hutch campus has changed over the last 50 years. Learn more: www.fredhutch.org/en/news/cent...

Congratulations to @lapointelab.bsky.social‬ on being named a 2025 Rita Allen Foundation Scholar! This award will support his critical research @FredHutch.bsky.social studying how healthy cells control protein production and how this control breaks down in disease.

We’re hiring two research administrators! Join us and help support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social. Learn more and apply:

Happening TODAY - Manuel Rosero’s dissertation defense! Title: Thermosensory Neurons Mediate Tactile-Dependent Locomotion Modulation in C. elegans Lab: Bai Lab, FH When: Friday, June 6, 2pm PDT Where: FH Pelton Auditorium & Zoom (email [email protected] for link)

Research administrators are crucial to our mission, helping support the innovative and exciting research happening in the Basic Sciences Division @FredHutch.bsky.social. We’re hiring two research administrators and would love for you to join us:

My Keynote Talk at the CSHL 50th annual meeting on Retroviruses is now online: leadingstrand.cshl.edu/Keynote/Medi... Some more general parts such as ~ the 8'30" mark with the "What I learned from Howard Temin" slide and ~ the 40' mark with the "What is important to me in science" section.