Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social www.sciencedirect.com/science/arti...

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!! www.nature.com/articles/s41...

The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.

We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋 👩‍🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt

🎉 2025 DFCI TPD event registration is open! 📆 Sep 11, 11:30 AM–8 PM ET, Boston 🔑 Keynote: Nathanael Gray 📝 Registration link: forms.gle/NLUSa51Btrtf... #TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology! careers.dana-farber.org/job/11813/as...

Postdoc positions available! Please re-post! Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at: avgoustilab.org

🚨 New preprint! Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...

Two great talks lined up for the final Friday Afternoon Seminars of the season! For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social! We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo. www.biorxiv.org/content/10.1...

Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome

Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

REVIEW 🚨 Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders. 📖 👇

Cell biologist and former @FredHutch.bsky.social division leader Dr. Jonathan Cooper retires. Learn about his many years of scientific discovery and time directing the Basic Sciences Division:

Standing up for science in Seattle!

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier: Download our curated and comprehensive database of funding opportunities for early-career faculty. Here: research.jhu.edu/rdt/funding-...

Hope to see many of my colleagues on Friday. www.eventbrite.com/e/stand-up-f... Science is for everyone. For everyone to do, and for everyone to benefit from. Weather forecast has also improved for Friday, but waterproof your posters just in case.

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction. We all need to speak out to save lives.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Excited about programming biology via induced proximity? Then mark June 2026 in your calendar and consider participating in the GRC Conference on Induced Proximity Modalities and Therapeutics that I am co-organizing with @danetteldaniels.bsky.social tinyurl.com/brtuffam

Targeting the most frequently mutated oncogene in lung adenocarcinoma promotes antitumor immunity @huazhanglab.bsky.social & team report on a degradation system that disrupts KRAS G12V and abolishes lung and pancreatic tumors in mice: https://www.jci.org/articles/view/174249

In a study published today in @jclinical-invest.bsky.social, @behnamnabet.bsky.social and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene.

Our latest work using TIRFM to uncover mechanisms that stabilize the centromeric nucleosome: www.embopress.org/doi/full/10....

50 years of Fred Hutch! Founded in 1975 to honor a brother, Fred Hutch Cancer Center pursued bold science, pioneered a cure for blood diseases that changed medicine and became a world-class biomedical research and clinical care institution. bit.ly/3DJq7aX #FH50

Many thanks to @jhigginswriter.bsky.social @fredhutch.bsky.social for this fantastic article showcasing our latest dTAG study! I am so proud of our amazing team!!

Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project! www.biorxiv.org/content/10.1...

Have you been interested combining Perturb-Seq screening with Cas12a’s unique capabilities for multiplexed guide RNA expression? Us too! So, we figured out some useful tricks to make that possible, which you can find in our new pre-print. Short thread below: www.biorxiv.org/content/10.1...

Very excited to share our work on targeted degradation of KRAS G12V, where we demonstrated the power of the dTAG approach in a lung cancer GEMM. This work is a collaborative effort from @behnamnabet.bsky.social (Fred Hutch), Kwok-kin Wong (NYU), @huazhanglab.bsky.social (UPitt) and others.

Nice write-up of the successful SMART TPD symposium in Shenzhen, China - co-organised with Nat Gray, Nieng Yan, Peng Chan and Shixiang Yan. So enjoyed the opportunity. #TPD #SMARTsymposia www.szbl.ac.cn/en/infomatio...

Wow. Very impressive work with in vivo dTAG looking at KRAS G12V. Lots more to learn with this technology, this is only the start. Congratulations Behnam and team!

Congratulations, Behnam! Beautiful in vivo use of FKBP-dTag!

🧪 Ready, set, degrade! So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: www.jci.org/articles/vie...

It’s been a great week having two new postdocs, Brandon Czowksi and David English, join our lab! Super excited to have these amazing scientists join our team to drive new E3 ligase and technology development projects.

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce... And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...

Hey #ChemSky! I teach a primary-literature-based #ChemicalBiology course, and I'd like suggestions for updating the readings. Target audience is 1st-year PhDs and senior undergrads on their way to PhD. Each week I'll add another unit to the thread for your suggestions. Thanks for your help!!

New week, updated starter pack. Now with 81 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease. www.cell.com/molecular-ce...

Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪 #chembio #TPD #CancerResearch www.biorxiv.org/content/10.1...

The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs careers-fhcrc.icims.com/jobs/28757/p...

Talent exists everywhere. Lab experience doesn’t. Fred Hutch’s Postbaccalaureate Scholar Program bridges the gap between college and grad school for aspiring scientists, providing recent college graduates $50,000 a year and benefits as full-time Fred Hutch employees.

So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer! www.nature.com/articles/s43...

go.bsky.app/HiUmJvm Created a starter pack of the @fredhutch.bsky.social faculty on here that I know of. Please feel free to continue to populate to help others as they migrate over from the other place.