I just ran the first n=1 dynamic regulome experiment. On myself. A 72-hour fast where we tracked all 4,000+ components of the genome regulatory 'software' to see how they respond And over 30% changed, most never mentioned in fasting literature Why does this matter?

The EUBIC-MS Developers Meeting 2025 in Brixen is off to a great start with keynotes by Pavel Sinitcyn, Katerina Nastou, and @willfondrie.com. #EuBIC2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Some diseases are too rare to be VC-fundable. Without grant funding, these patients get nothing—that’s unacceptable. NIH grants fund our work on a rare cancer with no approved treatments. Every year, we pay out of pocket for a third-party audit to prove there’s no waste, no fraud—just science.

Does anyone know if the savings will be re-invested into more grants? Or is this just slashing the overall budget of the NIH?

Love to see more teams getting into the multidimensional drug screening game with DIA proteomics. 380 kinases in one assay - pubs.acs.org/doi/10.1021/...

Getting a bit tight in the hallways #teamMassSpec #proteomics

That seems... like a reasonable number? I'm surprised it's not higher, especially since a postdoc will usually double their salary going into industry www.nature.com/articles/d41...

Cancer might be the most creative biologist - it's evolutionary "job" is to stress test every biological mechanism in our cells are see if promoted survival/fitness Apparently tumors can tunnel into lymphocytes and dump their mutated mitochondria? What a wild world

This is the perspective I was waiting for after seeing all the new transcription factor footprinting papers 👇

Nice discussion here - we're doing our part building the first proteomics search engine that can handle the scale needed for drug discovery www.nautilus.bio/blog/transla...

I'm not sure how I missed this, but apparently there's a flash of light when the egg gets fertilized!? Pretty wild www.nature.com/articles/sre...

Re-upping this reply thread from last night. Drugs don't come from nowhere, folks. And we're not ripping off the NIH, either.

New Drug Approval: Opdivo Qvantig from BMS www.drugs.com/newdrugs/fda...

Lots of really cool molecules here. The menin inhibitors are super important. No new transcription factor inhibitors, sadly. On to 2025 🚀

First @chorylab.bsky.social blog post! chorylab.substack.com/p/new-year-n...

Don't think I've ever read something this moving about gene regulation before

Wow. Very impressive work with in vivo dTAG looking at KRAS G12V. Lots more to learn with this technology, this is only the start. Congratulations Behnam and team!

People sometimes make fun of science that sounds stupid and random. Meanwhile, a study of lizard saliva turned into a peptide medication, which was turned into a diabetes medication, which was turned into a GLP1 weight loss drug, that just became the first therapy every approved for … sleep apnea

Spatial proteomics wins method of the year! Our team at @talusbio.bsky.social isn't using IF-based spatial proteomics, TF-Scan does provide a surrogate of protein localization within the nucleus, with enough throughput to be useful for drug discovery. www.nature.com/articles/s41...

One of the reasons I joined @talusbio.bsky.social was @afederation.bsky.social and @lkpino.bsky.social's commitment to open science 👏 One of the first posts on our new company blog is a repost from my own blog on #OSS in #proteomics. Check it out here: blog.talus.bio/p/the-case-f...

I'm processing some DIA data using #DIANN and looking at the data using the Viewer (excellent addition!), many peptides don't look impressive (to say the least). Is it possible to be more stringent in assigning frags to precursors? #proteomics

Really cool pipeline, excited to play around with this (someday)

Where would genomics be if the BAM/SAM file format was proprietary and Bamtools/Bowtie was closed source and prohibitively expensive? That's where the proteomics field is right now. Talus Bio's @willfondrie.com and a group of industry+academia leaders share -

You may have seen a recent pre-print [1] from Jain et al. with strongly worded claims against the experimental results in our DiffDock paper [2]. We initially declined to respond as we saw that this preprint contained falsehoods, misleading comparisons, seemingly deliberate omissions, ...1/n

😮 "And the preprint highlights a major problem behind the DiffDock team's approach. As a training set, they used roughly 98% of the known small-molecule-bound structures in the literature, and reserved the other 2% to evaluate the program's performance as a test set."