Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer. rdcu.be/eGUtj

Spectacular from Szoboszlai

1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years. Today's executive order includes a provision that will obliterate both functions.

Even hundreds of trucks would not be enough "There are an increasing number of children that need to be in the hospital because they can’t eat food. They have got to that stage of severe acute malnutrition where their bodies just can’t digest food. And so those kids need to be in intensive care."

Harrison Bader looks like all of the 1993 Phillies had a baby together

Jhoan Duran intro at Citizens Bank Park

That Duran entrance is going to be wild at CBP, grab me a $17 yuengling and let’s ride

NEW The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year Chokes off billions in research funding Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

Heartless murderers. www.nytimes.com/2025/07/24/w...

Our hearts are heavy for the grieving family of Jaime Alanis, who died from injuries sustained during a chaotic raid on Thursday. We will do everything we can to support them. We continue to work with the hundreds of farm worker families navigating the aftermath of this violent raid.

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity @cp-immunity.bsky.social www.cell.com/immunity/ful...

BREAKING: Palestinian witnesses and hospitals say Israeli forces opened fire toward hundreds of people waiting for aid trucks in central Gaza, killing at least 25 people.

#NoKings info for #Philly billypenn.com/2025/06/10/p...

“More than 30 Palestinians were killed by Israeli fire on Sunday as they went to receive food at an aid distribution point set up by an Israeli-backed foundation in Gaza, according to witnesses, with a hospital run by the Red Cross confirming it was treating many wounded.”

First Bluesky post… New paper out, following on FOXA observations of the @juliensage.bsky.social lab; nice collaboration with the @joanmassague.bsky.social lab led by a shared post-doc, Kenta Kawasaki www.nature.com/articles/s41...

Who's calling the shots at NIH? Sworn testimonies and internal e-mails reveal for the first time the breadth of DOGE's control over the world's largest public biomedical funder. DOGE has provided lists of hundreds of grants to cut, and DOGE is now reviewing ALL NIH awards before they're released

We're excited to share that Dr. Andy Minn will return to Memorial Sloan Kettering Cancer Center (MSK) as the inaugural Chair of MSK’s new Immuno-Oncology Program in August. Learn more about Dr. Minn: bit.ly/44Advyo

“States must act now to end the violence or bear witness to the annihilation of the Palestinian population in Gaza – an outcome with irreversible consequences for our shared humanity”

Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!

BREAKING: @aclu.org says Trump deported a child (U.S. citizen) with metastatic cancer without medication or consultation with physicians. This is the second child with cancer he's deported. www.rollingstone.com/politics/pol... @rollingstone.com

NEW: A federal judge raised alarm Friday that the Trump administration appeared to have deported a 2-year-old U.S. citizen to Honduras with "no meaningful process" — even as her father was fighting to keep her in the country. Details w/ @joshgerstein.bsky.social www.politico.com/news/2025/04...

I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.

fighting tears

Peter Marks’s resignation letter. Everyone should read this.

#Squamous #lungcancer cells aren’t all alike — the tumor is a mix of distinct cancer cell states! @lukeizzo.bsky.social & Oliver lab uncover #KRT13+ hillock-like, slow-dividing, immunomodulatory tumor cells that resemble the recently discovered normal lung #hillock cells (Lin et al, Nature, 2024).

UCSF, like all UC campuses, announced an immediate hiring freeze today. UCSF is the second largest employer in the city. There will be wide ripple effects in the Bay Area and beyond, including the future of biotech and pharma in the area. 🧪

The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy. taggs.hhs.gov/Content/Data...

Chilling to see this list of terminated NIH grants. Research on Alzheimer's, HIV, rare diseases, vaccines -- gone. Cancer centers closed, training grants & fellowships terminated. Young scientists stranded. Patients waiting for treatments that'll never come. Just sad. taggs.hhs.gov/Content/Data...

Elon Musk says that no one has died because he slashed humanitarian aid. I went to South Sudan to check if that's true. It's not. Meet Peter, Achol and Evan, ages 10, 8 and 5. The reckless actions of the world's richest men are killing the world's poorest kids www.nytimes.com/interactive/...

Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world. Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...

Hannah Frank @hannaherf.bsky.social, a Cornell PhD candidate, gave a speech last week at a "Stand Up For Science" rally on campus about her mother who died of brain cancer. Here's what she said about Trump's featuring of a childhood brain cancer survivor at his rally last night:

whyy.org/articles/mea... Lovely

Please enjoy my last ever post at Climate.gov/ENSO Blog. This afternoon I was fired by the Trump Administration 15 days before my 2yr probationary period ended on March 13. I have worked at NOAA since 2010, and I'm so incredibly proud of the work I did. If anyone wants a quote, let me know.

Three people, all unvaccinated, have been diagnosed with measles in North Jersey. www.inquirer.com/health/measl...

Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

Nick Sirianni To Eagles Fans: ‘I Hate All Of You, Fuck You’ theonion.com/nick-si...

go birds

With the Super Bowl on the line, Vic Fangio and the Eagles defense limited Patrick Mahomes to the worst game of his career, based on dropback success rate. The best defense in the NFL was dominant against the best QB in the NFL. And the Eagles are Super Bowl champs.

Need an Eagles fan to climb that pole behind Kendrick

This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction. We all need to speak out to save lives.

Go Birds.

New: Trump officials have paused all external communications at health agencies like CDC, FDA, NIH. No health alerts and the famed MMWRs; no updates to key websites or social media posts. And no indication how long the pause will last. With @rachelroubein.bsky.social + Lena Sun.

The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs careers-fhcrc.icims.com/jobs/28757/p...

Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...