Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...

Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer. rdcu.be/eGUtj

SCLC has tremendous plasticity but genetic events constrain it. Tour de force from @abireland.bsky.social & special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in #SCLC cancer @nature.com @dukeu.bsky.social @tgoliver.bsky.social @abireland.bsky.social www.nature.com/articles/s41...

Our lab frequently used BioRender to aid our grant submissions and publications—simplifying complex mechanisms of tumor evolution into beautiful schematics! Here is an example in one of our winning grants. #BioRenderForGrants

The basal cell begets SCLC! @abireland.bsky.social

Spread the word, mark your calendars, and check for your local rally information! Raleigh, NC — State capitol — 12-4pm. #standupforscience2025

Devastating for scientists and their research, and everyone who benefits from that research. I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.

Say it with me. They can regulate our words in a document, but they cannot regulate our thoughts, values, attitudes or behavior. Together, we make up nearly 50% of the population. The economy grinds to a halt without us. Say it with me.

Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...

Dear new #science #STEM community- @abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because: