Julien Sage
@juliensage.bsky.social
📤 470
📥 296
📝 16
Stanford, cell cycle, RB, cancer, SCLC, mouse models
Excited to share our new review on our current understanding of small cell lung cancer (SCLC) heterogeneity and plasticity, led by Gina Duronio in the lab:
www.tandfonline.com/doi/full/10....
3 days ago
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Ricardo Zayas
15 days ago
Please help distribute this announcement for the Ph.D. in Biology Program
@stowersinstitute.bsky.social
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Elizabeth McKenna
17 days ago
Now online in Cancer Discovery @aacrjournals.bsky.social: p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program by Mengxiong Wang, @AttardiLaura, and colleagues
doi.org/10.1158/2159...
@stanfordmedicine.bsky.social
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Bardin Lab
21 days ago
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026
cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social
and I have an exciting program of speakers and slots for selected short talks, etc.
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Dmitri Petrov
24 days ago
For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6. Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...
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https://docs.google.com/forms/d/e/1FAIpQLScswsjHaX0Rr12iDXznWc06c8Ck3BJoXQLI5vOLR2HLsURSOg/viewform
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Catherine Dulac
24 days ago
Our Primer on Sickness and the Brain: how are inflammatory signals and the brain coordinate to make us sick? in the new issue of Current Biology
www.cell.com/current-biol...
together with @Zuri A. Sullivan
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Sickness and the brain
Zuri Sullivan and Catherine Dulac discuss the reciprocal communication between the brain and the immune system in sickness behavior.
https://www.cell.com/current-biology/fulltext/S0960-9822%2825%2901116-9
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Nature
about 1 month ago
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
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Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
https://go.nature.com/4hj9NNV
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Elizabeth McKenna
about 1 month ago
Now online in Cancer Discovery
@aacrjournals.bsky.social
: Epigenetic and Transcriptional Programs Define
#Osteosarcoma
Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues
doi.org/10.1158/2159...
@ucsfchildrens.bsky.social
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Aguirre-Ghiso Lab
about 2 months ago
Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.
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Debbie Caswell
about 2 months ago
Our lab is hiring! This is for a postdoctoral position
@ucl.ac.uk
in Respiratory Medicine. Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
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UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?nPostingId=15795&nPostingTargetId=38221&id=Q1KFK026203F3VBQBLO8M8M07&LG=UK&languageSelect=UK&mask=ext
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BrunetLab
about 2 months ago
Interesting in aging, immune function, and organ health? Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
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Trudy G. Oliver
about 2 months ago
Super pleased to announce our latest suggesting the cell of origin for
#SCLC
is most likely the basal cell
@nature.com
, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
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Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
https://rdcu.be/eGUtj
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Glad to be back at CSHL!
about 2 months ago
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Sue Biggins
about 2 months ago
New cell cycle meeting starts next summer!
events.faseb.org/event/c40174...
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Cell Cycle Regulation in Health and Disease.
Explore breakthroughs in cell cycle regulation and its impact on disease and therapies at this new multidisciplinary scientific meeting.
https://events.faseb.org/event/c4017439-7fb7-40ca-8048-5f6b24d32975/summary
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Eric Topol
2 months ago
The cancer hijacking story expands..... 2 new reports of small cell lung cancer provide evidence for hijacking of neurons, formation of synapses, to promote tumor growth. May help to come up with therapies for this very aggressive, fatal form of cancer
www.nature.com/articles/s41...
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Elizabeth McKenna
2 months ago
Now online in Cancer Discovery
@aacrjournals.bsky.social
: An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat - by Alyssa Shepard, Daniel Lester,
@kissillab.bsky.social
, and colleagues
doi.org/10.1158/2159...
@moffittnews.bsky.social
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Julien Sage
Anna Obenauf
2 months ago
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms:
www.maxperutzlabs.ac.at/news/open-po...
Come be our colleague!
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Full Professorship in Molecular Mechanisms of Disease
The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...
https://www.maxperutzlabs.ac.at/news/open-positions/l/full-professorship-in-molecular-mechanisms-of-disease-100359
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Fendt Lab
2 months ago
Come join us for your next research endeavor in the heart of Europe!
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Brooks Benard
3 months ago
Excited to share that, a decade after its initial release, PRECOG has an update!
www.biorxiv.org/content/10.1...
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PRECOG update: An augmented resource of clinical outcome associations with gene expression for pediatric and immunotherapy cohorts
Gene expression can be used to define prognostic and predictive biomarkers across cancers and treatment modalities. PRECOG (https://precog.stanford.edu) is a compendium of datasets with gene expressio...
https://www.biorxiv.org/content/10.1101/2025.08.22.671849v1
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Anna Obenauf
3 months ago
Anyone working in metastasis research – the BEUG Foundation has once again opened the call for their Metastasis Research Prize. This prize is a wonderful recognition of innovative contributions and supports excellence in metastasis research across Europe.
www.beugstiftung-metastase.de/apply-now/
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Apply now – Beugstiftung
https://www.beugstiftung-metastase.de/apply-now/
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Nathan Reticker-Flynn
3 months ago
Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in
@natprot.nature.com
bsky.app/profile/nat...
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Nature Protocols (@natprot.nature.com)
New Article! Spontaneous and experimental models of lymph node metastasis https://bit.ly/4fzWoAj
https://bsky.app/profile/natprot.nature.com/post/3lwbhu2ukuc2e
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Gina DeNicola
3 months ago
Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here:
moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
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Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
https://moffitt-cancer-center-careers.hctsportals.com/jobs/1883440-tenure-earning-assistant-member-metabolism-and-physiology-faculty
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Julien Sage
Hunter Shain
4 months ago
Are you interested in following scientists in the Human Tumor Atlas Network (HTAN)? If so, this starter pack is for you!
go.bsky.app/AXaDeng
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The Bendall Lab
4 months ago
It's that time of year again!
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Nature Cancer
5 months ago
Another REVIEW now ONLINE at Nature Cancer 'Advancing therapeutics in small-cell lung cancer' ✒️By Anish Thomas, Chirayu Mohindroo & Giuseppe Giaccone 🔗
www.nature.com/articles/s43...
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Advancing therapeutics in small-cell lung cancer - Nature Cancer
Thomas and colleagues review the latest preclinical and clinical studies on small-cell lung cancer and outline future directions on therapeutic strategies highlighting a role for reverse translation i...
https://www.nature.com/articles/s43018-025-00996-1?utm_source=bluesky&utm_medium=social&utm_campaign=natcancer
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Julien Sage
Winkler Laboratory
5 months ago
Upcoming deadline for the EACR Cancer Neuroscience Conference: June 30th!! Don't miss it and submit your abstract today 👇
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Attending the 3rd Cologne Conference on Lung Cancer
#CCLC
, incredible mix of basic cancer research and translational/clinical science - so much progress, and, still so much left to do!
5 months ago
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BrunetLab
5 months ago
Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell
@goodell-lab.bsky.social
!!
www.sciencedirect.com/science/arti...
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Hallmarks of stem cell aging
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …
https://www.sciencedirect.com/science/article/pii/S1934590925002267
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euanashley
5 months ago
Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.
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Jason Moore
5 months ago
I heard this morning that my informatics colleague Dr. Atul Butte passed after a battle with cancer. He was a giant in the field & inspired many of us over his distinguished career. He was a passionate champion of the power of big data & his impact on our field is immeasurable. RIP Atul & thanks.
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Nature Cancer
5 months ago
🚨REVIEW ARTICLE JUST OUT at Nature Cancer! 'The current and emerging
#immunotherapy
paradigm in small-cell
#lungcancer
' ✏️By Lauren Byers, Jianjun Zhang and colleagues 🔗
www.nature.com/articles/s43...
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The current and emerging immunotherapy paradigm in small-cell lung cancer - Nature Cancer
Zhang and colleagues provide an overview of the current and emerging landscape of immunotherapy-based therapies for small-cell lung cancer.
https://www.nature.com/articles/s43018-025-00992-5?utm_source=bluesky&utm_medium=social&utm_campaign=natcancer
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Rob Noble
5 months ago
The Montpellier Institute of Molecular Genetics is recruiting group leaders (open rank). IGMM studies fundamental mechanisms underlying cellular processes and their links to human pathologies. Montpellier 🇨🇵 is an absolutely wonderful place to live. Deadline 31st October.
jobrxiv.org/job/montpell...
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Call for Group leaders in Innovative Biology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
https://jobrxiv.org/job/montpellier-institute-of-molecular-genetics-igmm-27778-call-for-group-leaders-in-innovative-biology/
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Julien Sage
5 months ago
A big advance for patients with SCLC today —
www.nejm.org/doi/full/10....
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Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy | NEJM
Tarlatamab, a bispecific delta-like ligand 3–directed T-cell engager immunotherapy, received accelerated approval for the treatment of patients with previously treated small-cell lung cancer. Wheth...
https://www.nejm.org/doi/full/10.1056/NEJMoa2502099
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Julien Sage
6 months ago
First Bluesky post… New paper out, following on FOXA observations of the
@juliensage.bsky.social
lab; nice collaboration with the
@joanmassague.bsky.social
lab led by a shared post-doc, Kenta Kawasaki
www.nature.com/articles/s41...
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FOXA2 promotes metastatic competence in small cell lung cancer - Nature Communications
Small cell lung cancer presents high and multi-site metastatic potential. Here, the authors discover that FOXA2, regulated by ASCL1, promotes multi-site metastasis in small cell lung cancer by inducin...
https://www.nature.com/articles/s41467-025-60141-5?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250526&utm_content=10.1038/s41467-025-60141-5
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Aaron Straight
6 months ago
Our most recent Synthetic Biology for Sustainability symposium was a great success. Lots of excellent ideas and creative approaches to sustainability. And a wonderful group of scientists too! Check here for more info on our Syn Bio efforts (
sb.stanford.edu
)
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Julien Sage
Stanford Cancer Institute
6 months ago
Congratulations to Stanford Cancer Institute member
@michellemonje.bsky.social
, who is one of the 120 newly elected members of the National Academy of Sciences.
news.stanford.edu/stories/2025...
@nasonline.org
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Stanford faculty elected to National Academy of Sciences
Seven Stanford researchers join the scholarly society, which works to promote science for public good.
https://news.stanford.edu/stories/2025/04/stanford-faculty-national-academy-sciences
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Barbara Marte
7 months ago
new out in Nature
www.nature.com/articles/s41...
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Cell cycle duration determines oncogenic transformation capacity - Nature
Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lea...
https://www.nature.com/articles/s41586-025-08935-x
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Nature
7 months ago
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
https://go.nature.com/42WjSd1
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The cell-division cycle is faster in cell types prone to forming cancer
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
https://go.nature.com/3GAgqwZ
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David MacPherson Lab
7 months ago
Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm
www.science.org/doi/10.1126/...
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Packed room at the
#AACR25
Opening Ceremony, quite inspiring to be with thousands of cancer researchers !
7 months ago
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Flora Rutaganira
7 months ago
Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium:
www.berkeleystanfordnextgensymposium.com
! Pls repost! (1/3)
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Steven Artandi
7 months ago
SCI members Max Deihn & Ash Alizadeh have developed a blood test for
#CancerDetection
and characterization that uses
#CirculatingTumor
RNA.
www.nature.com/articles/s41...
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Julien Sage
Jesse Engreitz
7 months ago
Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇
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Great news for patients with SCLC, the results of the Phase 3 trial with the DLL3 BiTE Tarlatamab (IMDELLTRA) are positive! Hopefully we will see the data soon!
www.prnewswire.com/news-release...
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IMDELLTRA® DEMONSTRATED SUPERIOR OVERALL SURVIVAL IN SMALL CELL LUNG CANCER
/PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the global Phase 3 DeLLphi-304 clinical trial evaluating IMDELLTRA® (tarlatamab-dlle) as a treatment...
https://www.prnewswire.com/news-releases/imdelltra-demonstrated-superior-overall-survival-in-small-cell-lung-cancer-302426291.html
7 months ago
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Nature Reviews Cancer
7 months ago
🐰#Weekendrreading #Review🚨 Caroline Dive&Co discuss the challenges associated with #ITH and plasticity in #SCLC and argue that combination therapies&liquid biopsy-based biomarkers are needed to improve patient outcomes. 📖⬇️
@cruk-mi.bsky.social
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Challenges of small cell lung cancer heterogeneity and phenotypic plasticity - Nature Reviews Cancer
In this Review, Simpson et al. summarize the emergent understanding of molecular subtypes of small cell lung cancer (SCLC). They discuss how intratumour heterogeneity and dynamic tumour plasticity may challenge the success of immune and molecular subtype-targeted therapies and argue that combination therapies, monitored by serial liquid biopsy-based biomarkers, will be needed to improve the outcomes of patients with SCLC.
https://bit.ly/4ct5UmZ?utm_source=dlvr.it&utm_medium=bluesky
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Billy Li
7 months ago
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential.
#ADAR
#RNAediting
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Debbie Caswell
7 months ago
I am excited to announce that my laboratory
@ucl.ac.uk
is now open! We are hiring so please contact us if you are interested.
www.caswelllaboratory.com
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Lung Cancer Prevention Laboratory
Pioneering research in lung cancer to improve diagnosis, treatment and prevention
https://www.caswelllaboratory.com/
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Wrapping up
#SCLC25
in NYC with a legend in the lung cancer field, Dr. John Minna! So much progress in the SCLC field in the past few years!!
7 months ago
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Julien Sage
Alex Knapp
8 months ago
My latest: Sean Parker's cancer fighting non-profit announced that former American Cancer Society CEO Karen Knudsen will be helming the organization. Parker tells me he plans to "double down" as government and markets pull back on research funding.
www.forbes.com/sites/alexkn...
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As Trump Cuts Cancer Research Funding, Billionaire Sean Parker Wants To Scale It Up
With a new key hire, the Napster cofounder’s cancer fighting non-profit is ready to back the science both governments and markets leave behind.
https://www.forbes.com/sites/alexknapp/2025/03/31/as-trump-cuts-cancer-research-funding-billionaire-sean-parker-wants-to-scale-it-up/
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Steven Artandi
8 months ago
It is incredible to see so many passionate researchers at the Stanford Cancer Institute Retreat today!
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