My quote of the day A Video Quote Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble. (From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.' www.nytimes.com/2025/07/10/s...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.

Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.

Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!

💯 👇!

Today they have crossed a deep red line. We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.

Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.

Tagging a few bioorganic aficionados @laurakiessling.bsky.social @carolynbertozzi.bskyverified.social @krishnanyamuna.bsky.social @chembiobryan.bsky.social @chembiohub.bsky.social @pottslab.bsky.social @dannomura.bsky.social @danharki.bsky.social @craigmcrews.bsky.social @ritastrack.bsky.social

I have had the privilege to train many chinese students over many years. They enriched our lives and did great science. Many are still here and contribute to the US scientific enterprise. The push to revoke student visas is cruel and unnecessary. We must push back. www.npr.org/2025/05/28/g...

Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4 - Journal of Biological Chemistry www.jbc.org/article/S002...

📣New from Palafox et al! 📄Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids

Fucking hell

Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!

Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues. #ADPribosylation #ubiquitination #MARUbylation #crosstalk authors.elsevier.com/sd/article/S...

Primary @embojournal.org article: "Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose" from @michaelnadbio.bsky.social, @jnpruneda.bsky.social, and colleagues. www.embopress.org/doi/full/10....

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation??? Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

Thanks @kfeijszaja.bsky.social and team for the excellent Spotlight on our collaborative work with @jnpruneda.bsky.social: Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells: Trends in Biochemical Sciences www.cell.com/trends/bioch...

Great article on the importance of humor by the late Pope Francis: “Irony is a medicine, not only to lift and brighten others, but also ourselves, because self-mockery is a powerful instrument in overcoming the temptation toward narcissism.” www.nytimes.com/2024/12/17/o...

Interested in starting your cancer research career in London ?We're looking for a Scientific Officer to support our work on synthetic lethality in triple negative and BRCA1/2 mutant cancers. Ideal job for a new graduate who wants to kick start their research career. jobs.icr.ac.uk/vacancies/12...

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost. www.training.nih.gov/research-tra...

Another great addition to the PARP/ADP-ribosylation field! Leung lab shows that PARP14-mediated ADP-ribosylation promotes the formation of non-canonical p62 bodies. Will be exciting to figure out their functional role.

Today there are two symposia at the ACS in honor of Peter Dervan (11AM & 5PM). Although I can't be there to celebrate, I wanted to share a few reflections on my time in his lab (2009-2012) and the impact he's had on me as a scientist.

Excellent article by Dr. Jonathan Cole highlighting impact of academic freedom and fundamental research on advancing human health and economic prosperity, and the urgency of safeguarding them. www.nytimes.com/2025/03/24/o...

New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs: In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation". www.embopress.org/doi/full/10....

Thanks Isaac de Araujo Matos and Nicolas Hoch for this wonderful “News and Views” in @embojournal.org on our recent collaborative study with @jnpruneda.bsky.social: www.embopress.org/doi/full/10....

‘We should be investing more in science, not less,’ write OHSU professors Tim Nice, Jonathan Pruneda, Isabella Rauch & Lauren Rodda. NIH research saves lives & drives the economy in Oregon 🦫 @rauchlab.bsky.social @jnpruneda.bsky.social @laurenrodda.bsky.social 🧪🏠 www.bizjournals.com/portland/new...

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...

Excellent new paper from @kfeijszaja.bsky.social and team looking at site- and target-specific ADP-ribosylation reversal. Check it out!

Since @stephanieaw.bsky.social left the lab to start her group at Vanderbilt, we've been talking regularly on the ups and downs of academic science. We started recording... The Tortured Proteins Department open.spotify.com/show/10PHVou... (science with a small dose of running and Taylor Swift)

New Paper💡PARP enzymes regulate ADP-ribosylation, a protein modification linked to cancer, infections & neurodegeneration. But it comes with two forms—MARylation (single) & PARylation (multiple). Meet dELTA-MS, a mass spec method that identifies both in one experiment! pubs.acs.org/doi/full/10....

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...

Grateful for all the people mobilizing across the US and the world for #StandUpForScience! Many reasons motivating this movement, but yesterday as I was reviewing undergrads applications for summer internships, I was reminded of how important this is for the next generation of scientists.

Very cool study by my colleague @tomo.science and collaborators showing the power of crypto-electron tomography for providing insight into the spatial organization of cytoplasmic ribosomes at the surface of mitochondria. Keep on eye out for more awesome work from his lab!

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new... It was signed by over 450 OHSU researchers! It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

@ohsunews.bsky.social folks let’s make our voices heard!

Tom Maniatis coming in hot in @CellCellPress to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science. And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯 www.cell.com/cell/fulltex...

eRA Commons is down, too. Hopefully that changes by Monday so I can submit my grant.

#MARUbylation: @michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-β induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14 www.embopress.org/doi/full/10....

I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....