A PAR spark lasting seconds. A FUS condensate that's still there long after. How does a signal that fleeting leave a structure that stays? Sharing this + new work on stress granules & antiviral defense next Tue Apr 28, 2:30pm at UW Pharmacology. Thanks to @shaoenong.bsky.social for hosting!

ADP-ribosylation doesn’t act alone. Nice work showing how DTX2 generates a hybrid ADPr–ubiquitin mark at DNA damage sites — linking ADPr signaling directly to ubiquitin pathways.

PARPs don’t just modify proteins — they shape how condensates form and behave. I’ll be speaking at Baylor College of Medicine on ADP-ribosylation in condensates and antiviral signaling. Wed Apr 8, 11am CDT (hybrid) If you’re nearby, come by — always better in person.

ADP-ribosylation is far more diverse than the usual mono vs poly view. New sensitive tools from the Ivan Matic lab to resolve this complexity are a big step forward — expanding what more labs can now study. www.nature.com/articles/s41...

PARPs never fail to surprise. Back @cshlbanbury.bsky.social — I kicked off a session on PARP stress responses, chaired a structural biology session, and joined a panel on PARP technologies. What’s striking right now: ADP-ribosylation spans both proteins and nucleic acids

Flu infection flips a “PAR switch”: instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus. Flu NS1 suppresses this; PARP1 drives it. ELTA revealed both site & length changes. www.nature.com/articles/s41...

What if RNA had a molecular twin? Our new study w/ the Bedford Lab (MD Anderson) shows poly(ADP-ribose) (PAR) competes with RNA for the same proteins—creating RNA–PAR crosstalk. Unlike RNA, PAR’s info isn’t in sequence but chain length. 🔗 academic.oup.com/nar/article/... #PARcode

A whirlwind few days in Cancún for the 2nd Spatial Genome Conference Great science, great people — and a reminder why we do this. After 20 yrs in nuclear organization, ideas once “unorthodox” (like nuclear actin) are now gaining mainstream. Science moves, so should we. @fusionconf.bsky.social

A whirlwind few days in Cancún for the 2nd Spatial Genome Conference 🌊 Great science, great people — and a reminder why we do this. After 20 yrs in nuclear organization, ideas once “unorthodox” (like nuclear actin) are now gaining mainstream. Science moves, and so should we.

Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai! 🔗 www.nature.com/articles/s41...

Have you already seen this research article, recently published in LSA: PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...

This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment @leunglab.bsky.social www.life-science-alliance.org/content/8/12...

How do our cells build “emergency rooms” when under attack? New from our lab in Life Science Alliance: PARP10 triggers stress granule formation—revealing a way to tune how cells respond to stress, infection, or cancer. Read: www.life-science-alliance.org/content/8/12...

As the Chair of Innovation Translation Council, venturing beyond lab science at the Bloomberg American Health Summit 2025. A lot to absorb — and much to reflect on about scaling public health innovation to reach millions. Grateful to Josh Sharfstein for making it possible to attend 🙏

The @johnshopkinssph.bsky.social Office of Research launched the Innovation Translation Council, chaired by BMB Professor Anthony Leung (@leunglab.bsky.social)! The ITC will connect researchers at the School with resources to translate their innovative research into community impacts. Learn more ⤵️

What a fantastic day of science at FCBIS! @friedlab.bsky.social and I had a blast co-organizing this exciting dive into the chemistry-biology interface—great conversations, amazing energy, and a standout keynote by @edwardmarcotte.bsky.social. Thanks to all who joined us!

Interferon function couples immune signaling to the ubiquitin–proteasome system. Study from the @leunglab.bsky.social @johnshopkinsbmb.bsky.social 🆕 #preprintpeerreview @biorxivpreprint.bsky.social Referee reports and author's response letter available here --> doi.org/10.1101/2024...

Great to get to publish another one on the emerging connections between ADP-ribosylation, immune signaling, ubiquitin and protein aggregation/degradation

🥳 Out now @embojournal.org! Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications. p62 is usually linked to #autophagy — but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

In the midst of funding uncertainty in D.C., our lab took a moment to see the cherry blossoms. We’re not naive—we know the challenges. But we believe in science, in community, and in each other. We’re in this together.

New Paper💡PARP enzymes regulate ADP-ribosylation, a protein modification linked to cancer, infections & neurodegeneration. But it comes with two forms—MARylation (single) & PARylation (multiple). Meet dELTA-MS, a mass spec method that identifies both in one experiment! pubs.acs.org/doi/full/10....

Be sure to also read about: ☘️ #Nrf2 activity regulation by #UbLigases (Albena Dinkova-Kostova et al) ☘️ roles of structured domains in #biomolecularcondensates (@jerelleaj.bsky.social et al) ☘️ PARPs and ADP-ribosylation-mediated #biomolecularcondensates (@leunglab.bsky.social et al) ...

I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....

Celebrating 14 years of science, teamwork, and resilience! To mark our lab’s anniversary, we traded pipettes for pottery—turns out shaping clay is just as therapeutic as shaping experiments. With NIH funding uncertainties, a little calm goes a long way. Grateful for this team! #LabLife

Excited to share our new review on biomolecular condensates mediated by PARPs and ADP-ribosylation @ Trends in Biochemical Sciences! Despite the uncertainty, science must march forward. Grateful for the support that makes discovery possible. #FundScience #KeepScienceStrong

A Primer on Indirect Cost Rates

Thanks for highlighting our work, Marcin!

🔥 Most studies on condensates focus on their formation—but what about their maturation? Our research reveals PARP13 binds poly(ADP-ribose) (PAR) to drive stress granule maturation. Mutate the binding sites? Granules fragment like crazy! Read the full story here: www.nature.com/articles/s41...

🎄✨ Merry Christmas and Happy New Year! ✨🎄 A big thank you to our amazing team for all the hard work and for creating such a collaborative, friendly environment. Here's a little glimpse from our Christmas lunch—we’re grateful to celebrate the season together! 🥂❤️ #Teamwork #celebration

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on [email protected]

No greater joy than seeing a student who completed both her master’s and PhD in my lab at Hopkins go from being afraid of public speaking to confidently presenting her research at the NIH yesterday. Moments like these make it all worthwhile! 🎓👏 Way to go, Dr. Shang-Jung Cheng!

Post a photo of yourself from a different era (1999 - undergrad 4th year project @ Oxford working with @marstonlab.bsky.social when we were in Jeff Errington’s lab @dunnschool.bsky.social) Yes, definitely an era before 😊 Happy Thanksgiving for those who celebrate today 🥳🎉

From my trusted public health colleagues..

The first hint I had that something was amiss in late December, 2019, was a post from @helenbranswell.bsky.social about a pneumonia of unknown etiology in Wuhan, China. Here's Helen speaking about three recent, abnormal H5N1 cases. It's not panic time yet, but it's worth paying attention.

Let’s talk turkey! 🦃 Keep your holiday feast safe by following our tips on handling, thawing, cooking, and storing your bird properly to avoid the spread of any harmful bacteria. For more info: www.cdc.gov/food-safety/...

Did some tidying up of the links for chemistry related starter packs, arranged loosely by subject area, and added who maintains the list so you know who to speak with if you'd like to be added! tinyurl.com/ChemSkyStart... #ChemSky #Chemistry #Chemists #StarterPacks 🧪

Can’t find your people? 🤔 This new free app from @blueskystarterpack.com lets you search through 36,000+ starter packs (and counting!) to connect with your vibe in seconds. 🚀👏 #FindYourTribe #StarterPackSearch

Another patient mutation in PARP-linked pathways is tied to neurological diseases. Excited to see how discoveries like the #ADPRS variant in CONDSIAS push us closer to unlocking new therapeutic pathways! 🧠🔬 #Neurodegeneration #ARH3 #ADP-ribosylation. Congrats @danglab.bsky.social!

Do you need a starting pack of researcher working on intrinsically disordered proteins? Well, you might head over to @idpseminars.bsky.social and hit followers. Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 @chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz www.biorxiv.org/content/10.1...

Finally moved to #Bluesky and happy to share our recent work about a new phage anti-defense system, based on NAD reconstitution by new enzymatic reactions. www.nature.com/articles/s41...

Patients and patient advocates: consider visiting your congress representatives offices to advocate for funding for research. The development of new treatments and diagnoses require funding of basic and translational research in academic laboratories.

Amazing compilations for everyone to join this new sky!!

Check out our updated database of 189 PhD fellowships and funding opportunities. For each fellowship, we provide a description, $ amount, deadline, link to funder and eligibility criteria (such as citizenship). Good luck! Download freely here: research.jhu.edu/rdt/funding-...

Some of them are faster than others, but watch this starter pack for updates - go.bsky.app/KxWyLE4

Biomolecular condensate starter pack! Trying to compile & to bring together biomolecular condensate enthusiasts & critics! Please join this non-exhaustive (sorry!) collection & just ping me for addition. #condensates, #phaseseparation, #granules, #IDPs go.bsky.app/NFqmffa

Celebrating a new sky, fresh air, and endless horizons ahead!

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

It’s so refreshing to see back all the scientific posts I once enjoyed reading. What a loss that was for our community—grateful to reconnect here! 🙏 🦋

interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social go.bsky.app/CiRKAXJ