Christopher Frank
@chrisfrank662.bsky.social
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📥 89
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De novo Protein Designer DNA Origami wizzard I like lifting rocks PhD student @TU_Muenchen
reposted by
Christopher Frank
owl
7 months ago
tomorrow!
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Cant wait for the first tests 🚀
add a skeleton here at some point
9 months ago
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This is awesome! Great work! 🔥
add a skeleton here at some point
9 months ago
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This
www.biorxiv.org/content/10.1...
Is so, so, so damn important work! 🔥 The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations. Time that we start "designing the un-Designable" 😆
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https://www.biorxiv.org/content/10.1101/2025.01.09.632260v1.full.pdf
10 months ago
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Crosspost from X: After showing that AF2 can be used to design very large proteins by performing
#RSO
, I am happy to share another fun project we did: the
#af2cycler
@sokrypton.org
@hendrikdietz.bsky.social
www.biorxiv.org/content/10.1...
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Alphafold2 refinement improves designability of large de novo proteins
Recent advances in computational protein design have enabled the creation of novel proteins for a variety of purposes. The capability for producing custom-shape high-quality backbones for very large p...
https://www.biorxiv.org/content/10.1101/2024.11.21.624687v1
12 months ago
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reposted by
Christopher Frank
Gabriele Corso
about 1 year ago
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
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