Experimental verification is increasingly the bottleneck in protein design projects. In this paper, we develop a new mini-binder screening pipeline based on the microfluidic sizing technique called flow-induced dispersion analysis (FIDA). doi.org/10.1002/pro....

How do we screen do novo designed binders most efficiently? In this pre-print, we show that the microfluidic sizing technique FIDA allows us to pick successful binders in a single measurement using minimal sample: www.biorxiv.org/cgi/content/...

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...

Reactionaries hate universities because they create open-minded liberated people open.substack.com/pub/iandunt/...

Our annual report 2024 is out! Dive into our research highlights, talent development, collaborations, and new events and initiatives. dandrite.au.dk/annual-repor...

🚨We have an opening for a postdoc to use protein design techniques to developing and characterizing binders against intrinsically disordered proteins involved in neuroscience. Experience in protein biochemistry and/or molecular neuroscience preferred. Share: 🙏 mbg.au.dk/aktuelt/ledi...

The most wholesome Fox News show: 5 fox cubs playing in our garden.

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

Baby fox in the garden!

Trigger warning: FOMO How often do you go to a conference where you are excited about EVERY SINGLE TALK! Well, I guess it helps if you get to make the program. 😀 "Biomolecular condensates: From fundamental principles to applications in health and biotech" kicking off at 9 AM!

Probably the best conference venue in Denmark? Tomorrow, we kick-off our condensate meeting in the Carlsberg Academy ⬇️. Thank you to the Novo Nordisk Foundation for the grant to host our dream meeting, and to the Carlsberg Foundation for hosting us at this beautiful site.

We have a new review/perspective on the potential of biomolecular condensates in microbial cell factories. The emphasis is on the trade-offs that have to be navigated when designing such synthetic organelles.

Since the Trump team are making videos about US-Greenland history, maybe the next one could be about that time when USAF crashed a B-52 spilling four nuclear bombs - one of which his probably never been recovered: en.m.wikipedia.org/wiki/1968_Th...

Dear American friends. We agree that status quo in the Artcic is not an option. So let’s talk about how we can fix it - together. Lars Løkke Rasmussen Danish Foreign Minister

Surprised - in a good way - to find myself as a recipient of a big teaching national prize within Natural Science together with good colleagues @ditlevbrodersen.bsky.social and Gregers Rom Andersen. nat.au.dk/en/about-the...

IDPSeminars is back this week (Tomorrow, March 6th)! Come hear about nucleolar organization and IDRs in host-pathogen interactions! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...

Authoritarianism runs strong in this family. It is an utter disgrace. The world order has changed. The US is no longer the leader of the free world. The key question going forward: Who is? Which side of history do our politicians choose - and who will lead?

The United States is giving up strong alliances, prosperous trade relationships, checks and balances, the rule of law and democratically-accountable government in order to become the Belarus of North America. Welcome to the American Oblast of the Russian Federation.

Congrats to Alain for napping a Marie Curie postdoc fellowship to work on condensates! 2nd Curie fellowship for the lab after @mcd611.bsky.social got one last year! Who will be number 3? 😏

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

We are recruiting two new colleagues at the department of Molecular Biology. Come join us! Denmark is a great place to live, science funding is really good, and the people are nice. Message me if you have any questions mbg.au.dk/aktuelt/ledi...

After many months of gathering user feedback and improving our software, we think it's time to share it with the community. Enjoy our latest tool 🥳 , and stay tuned for the next one 😉

Another 👇opening for a postdoc🚨. Focus: Structural biology, membrane proteins, biophysics, sugar and hormone transport in plants☘️🔬👩‍🔬🧪 We are recruiting: - Deadline 28. Feb 2025. - 2(+2) year position. - Details and application link: tinyurl.com/yc43bhzs - PM for questions Please repost 💚

🌱 We're hiring! Join our new ⭐Center of Excellence⭐, Plant-PATH, as Center Administrator and help us drive basic research in plant molecular biology🌱. www.au.dk/om/stillinge... #Science #dkforsk #dkscience #dkvid #JobOpening #Research

✨ Exciting news! I’ll be at the 2025 @biophysicalsoc.bsky.social Meeting in Los Angeles 🌴☀️ presenting my poster: “DE NOVO ENGINEERING OF INTRINSICALLY DISORDERED DESICCATION CHAPERONES” 🧬. Let’s connect! 💬 #Biophysics #IDPs #ProteinEngineering #BiophysicalSociety #ScienceConference

Impressive outreach setup at Aarhus Uni’s “Ole Rømer Observatory”. A shame that it is always clouded here though 😅☁️

The Danish Villum Foundation seems to be concerned about the cost of writing unsuccesful grants and are experimenting with their call to solve this. Examples: * Pre-application lottery for who gets to apply * Institutions are only allowed to apply in alternating years

PhD opportunities (yes, plural!) We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism. - Details and application link: tinyurl.com/44hf9zkd Please repost 💚

Interested in membrane proteins, biophysics, structures and hormone transport in plants?☘️🔬👩‍🔬🧪 Our new Plant-PATH center is launching soon, and we are looking for 1-2 PhD students to join from day 1.⭐ - Deadline 1. Feb 2025. - Details and application link: tinyurl.com/44hf9zkd Please repost 💚

We're back for 2025! This week we welcome Adam Klosin and Randal Halfmann for the first IDPSeminar of Season 17!

Interested in structural biology, membrane proteins, biophysics and working onto understand hormone transport in plants?☘️🔬👩‍🔬🧪 We are recruiting a postdoc: - Deadline 20. Dec 2024. - 2(+2) year position. - Details and application link: tinyurl.com/y7vnewen - PM for questions Please repost 💚

What is the most rigorous way to determine the cloud point of a phase separating system from scattering data (as the attached)? We had a long discussion about this at group meeting yesterday without reaching a clear conclusion?

IDPSeminars returns this week! Sign up here! idpseminars.com

Reminder that if disordered proteins are your thing, this starter pack exists (and I try to update it as best I can as new folks reach out/I see them!) 🍝 go.bsky.app/J23B51L

Suggestions needed! I am developing the "Expression and purification" part of a protein science course (final year bachelors degree) and I need to find a concise text on how to produce an uncharacterized protein. I.e. not how columns work, but choosing the right strategy (organism, tags, etc.)

What is the worst number of figure panels to have to arrange in a aesthetically pleasing manner? And why is it either 7, 11 or 13?

Do you need a starting pack of researcher working on intrinsically disordered proteins? Well, you might head over to @idpseminars.bsky.social and hit followers. Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.

1/ Our lab’s first preprint found a wonderful journal home! 🎉 Our paper explores the role of testis-specific transcription factors in Drosophila and reveals broad functional connections between tissue-specific paralog proteins. 📝 Link: genesdev.cshlp.org/content/earl... Thread 🧵👇

Do you know our next PhD students? We have two openings starting this summer, one for engineering of biomolecular condensates, and one for de novo design of protein binders (and their applications). Details ⬇️

On Thursday, we welcome Ayala Lampel (Tel Aviv Uni) and Karen Duff (UK Dementia Research Institute) at IDPseminars. Topics will be minimalistic peptide condensates and abnormal tau in neurodegenerative disorders. New attendees can sign up at: idpseminars.com

The joys of navigating the European train system amid overlapping German and Belgian train strikes include visiting unexpected destinations 😌

Peer review - pro-tip! 😎

New toy in the lab! Thanks to the Carlsberg Foundation (and beer drinkers around the world) our core facility has a brand new ITC (Malvern PEAQ-ITC). Looking forward to all the data it will generate!

Are interactions between intrinsically disordered proteins too naughty for Microsoft? My entry in the "PhD thesis title as DALL-E 3 prompt" was declared "unsafe content".

New lab equipment/art installation designed by the technicians on our floor. 😂

IDPseminars happening tomorrow! CEST 19:00, UK 6PM, Eastern 1PM, Pacific 10 AM, New Zealand Friday 6 AM (sorry Davide, but thank you for your dedication!) Link should have been sent out by email to those already registered. New attendees sign-up at: www.idpseminars.com

The AI apocalypse just moved closer! Now they have learned to use knives! 😳

1. Imagine we land a space probe on one of Jupiters’ moons, take up a sample of material, and find it is full of organic molecules. How can we tell whether those molecules are just randomly assembled goo or the outcome of some evolutionary process taking place there? 🧪

Exciting big box waiting outside our biophysics core facility!

Time to put the tortoises in the fridge. See you in six months!