Day 2 started with a great talk by Andrea Sinz on the application of XL-MS for studying IDPs #ml4ngp

Today’s talks ended by San Hadži He presented: A fuzzy-to-ordered switch in the binding mode of the disordered regulator HigA2 mediates a ratio-sensing gene circuit #ml4ngp

IDRs in mycobacterium transcription by Lukas Zidek #ml4ngp

Next: Achieving Predictive All-Atom Simulations of Disordered Proteins and Condensates By: Milos Ivanovic #ml4ngp

3rd keynote speech an amazing talk by Ben Schuler: Probing the Rapid Interaction Dynamics of Charged Disordered Proteins #ml4ngp

Another amazing talk by Sveinn Bjarnasor on Sox2 promotes chromatin accessibility via distinct mechanisms directed by intrinsically disordered regions #ml4ngp

The 6th talk by Dirk Linke on intrinsically disordered in bacterial surface proteins #ml4ngp

Zsuzanna Dosztanyi presented: Variant effect predictors in IDPs are systematically biased #ml4ngp

The 2nd keynote speaker, Michael Feig, presented : peptide dynamics inside condensates of different scales #ml4ngp

3rd talk by Juan Cortes: Generative design of idps based conditional protein language models #ml4ngp

Key tools for using pLMs presented by Michael Heinzinger #ml4ngp

2nd speaker: Beyond static structures: how pLMs help understanding protein flexibility #ml4ngp

1st keynote talk by Rohit Pappu Phase transition of RNA-Binding Non-Globular Proteins #ml4ngp

Last #ml4ngp conference has just started in Warswa-Poland

We (@sobuelow.bsky.social & @kejohansson.bsky.social) tested AF-CALVADOS using the recently described PeptoneBench SAXS benchmark that contains SAXS data for >400 proteins with different amounts of order and disorder. The results look pretty good 😇 so we are sharing here while updating the preprint📝

🚀 New Preprint Alert! We’re excited to share our latest work on a community-driven framework for determining conformational ensembles of intrinsically disordered proteins (IDPs) — now available as a preprint on arXiv! 📄 Read the full preprint here: [ arxiv.org/abs/2504.03590 ]

Supervised training using data generated by multiplexed assays of variant effects is potentially very powerful, but is made difficult by assay- and protein-specific effects Here @tkschulze.bsky.social devised a strategy to take this into account while training models www.biorxiv.org/content/10.1...

Announcing the joint IDPSeminars / BPS IDP Subgroup Trainee Symposium Speakers! Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now at docs.google.com/forms/d/1L_K...

Today we have published BioEmu-Benchmarks (MIT license): a code to evaluate the multi-conformation sampling benchmarks, MD free energy landscape benchmarks, and folding free energy benchmarks shown in the BioEmu-1 paper with BioEmu or your own model. Some details below 🧵 github.com/microsoft/bi...

The answer is yes! Come hear about STARLING this afternoon at the Biophysical Society IDP subgroup symposium! Thread to follow later today... www.biorxiv.org/content/10.1...