#paper #highlight February 2026 Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule By S. Bielskutė-García et al in #ScienceAdvances sbe.es/highlights-p... @xsalvatella1.bsky.social @irbbarcelona.org @icreacommunity.bsky.social

📢 Upcoming Seminar | Join us for a plenary seminar this Friday, with Dr. @adelaljord.bsky.social, from the @crg.eu. 🤝 Hosted by Dr. @xsalvatella1.bsky.social  Register here ➡️ https://shorturl.at/A9VMZ #IRBBarcelona #Seminar

Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!

Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation link.springer.com/article/10.1...

In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT

An excellent review on a fascinating topic !

Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve

📢  #MAINFRAME Symposium comes to Barcelona! Experts in #AI, computational chemistry & small-molecule #DrugDiscovery meet to advance open, large-scale screening for 2,000+ human proteins. 📆 Mar 18–19 📍 Ateneu Barcelonès ℹ️ https://shorturl.at/1aKKS @ptck72.bsky.social

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...

How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

You can’t miss this video we shared today during the tribute to Dr. #JoanGuinovart. Today, the scientific community, institutional leaders, colleagues, friends, and family gathers to honour the life and legacy of the founder and first director of #IRBBarcelona. 🎥 youtu.be/_SJ5Rudj2ik

📌 Don't miss our plenary #seminar this week, with Prof. Edward Lemke, from @unimainz.bsky.social.  Host: Dr. @xsalvatella1.bsky.social#seminar #IRBBarcelona Register here ➡️ https://shorturl.at/I58yN 🧪

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

I'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se

Thank you Fundación @bbvaenespana.bsky.social for supporting our collaboration with Michael Krieg of @icfo.eu !

Antoni Gaudí’s vision for the Sagrada Família, a church that’s been under construction for nearly 150 years, was never universally liked. George Orwell called the church “one of the most hideous buildings in the world.”

RFK Jr has vowed to find out what’s responsible for the rise in autism diagnoses, but scientists say he is ignoring answers from decades of research go.nature.com/47R4brs

Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out: eeik.fa.us2.oraclecloud.com/hcmUI/Candid... Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.

New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute. www.crg.eu/en/news/moni...

Congratulations to RSC-ESR group committee member Adam Brookfield and his colleague, Dr Muralidharan Shanmugam, for winning the RSC Technical Excellence Prize for their operations of the EPSRC NRF for EPR in Manchester, UK. www.manchester.ac.uk/about/news/f...

🏆 La investigación sobre la causa del #autismo, premio #VanguardiadelaCiencia 2025! ¡Enhorabuena a las premiadas: Dra. Carla Garcia Cabau y Dra. Anna Bartomeu, del #IRBBarcelona!👏👏👏 ➡️ https://shorturl.at/1hXF0 @lavanguardia.com @xsalvatella1.bsky.social  🧪

Today’s uniquely challenging biotech climate may result in a more resilient sector nature.com/articles/s41... rdcu.be/etg7h

“What is common knowledge in your field, but shocks outsiders?” Most drugs have several activities in the human body, and discovery of these effects goes on for years after they are on the market.

...the amino-acid sequence does not necessarily determine 3D shape, because many of our proteins have functionally crucial disordered regions that don't really have a shape. (Sometimes they fold on binding, perhaps in a ligand-specific way, sometimes they don't.)...

Here's an anniversary worth celebrating!

Patent departments have budget targets that lead to “pound foolish” decisions to abandon all the time.

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...

Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42... Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran... @irbbarcelona.org @xsalvatella1.bsky.social

The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...

Looking for a senior lecturer (associate #professor) position in #biochemistry? Come and join our neighbouring department at Uppsala University: www.uu.se/en/about-uu/...

The Structural Biology and NMR Laboratory—or SBiNLab as we call it—is turning 25 🎉🧲🇩🇰 We're celebrating with a symposium on Aug. 23 that is free and open to all Great speakers incl. Ad Bax, Frauke Gräter, Harald Schwalbe, Sarah Shammas, Mikael Akke & alumni! Join us: www1.bio.ku.dk/english/rese...

Looking for a postdoc in the beautiful city of Barcelona? Are you interested in biocatalysis, enzymes, structural biology (NMR, SAXS, etc.) and sustainable chemistry? The Biotransformation team (PIs Prof. Pere Clapés and myself) is looking for candidates to apply for the MSCA-PF 2025 call (1/2)⏬

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry. Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science. (1/4)

Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets https://go.nature.com/4jedGUz

🚨New research! #NMR study reveals hidden interplay between ordered and disordered regions in the CBP TAZ4 construct—shedding light on complexity often missed by traditional #structuralbiology Read more about this research conducted under the #ITACA.SB project! @instruct-eric.bsky.social

We investigated the interfacial orientations of scaffold molecules vs. adsorbents in model condensates formed by pairs of RNA molecules with PEG. Experiments identify purine-rich RNAs as scaffolds & pyrimidine-rich RNAs as adsorbents that undergo wetting transitions. www.nature.com/articles/s41...

Join us in our plenary #seminar tomorrow, with Prof. Ben Schuler, from the University of Zurich. Hosted by Dr. @xsalvatella1.bsky.social  Save your spot now ➡️ https://shorturl.at/tflid 🧪

Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower BMI, and lower fat accumulation around internal organs, suggests a study in Nature Metabolism. https://go.nature.com/4i3EYM0 🧪

So looking forward to this !

#compchemsky A change of paradigm in the use of MD is required. Trajectories should be stored under FAIR requirements to favor its reuse by the community under an open science paradigm. Happy to be part of this letter, now out @naturemethods.bsky.social #biosky www.nature.com/articles/s41...

🙋‍♂️Te esperamos esta tarde a partir de las 17.30 horas en el Aula Magna de la Facultad de Farmacia de la @ub.edu. 🔴Si no puedes asistir presencialmente, sigue en streaming la mesa redonda sobre atención al autismo en este enlace 👇 teams.microsoft.com/dl/launcher/...

Our March newsletter is hot off the press and FULL of great information: our 2025 Award winners, our 2024 Best Paper winners, the introduction of our new Protein Society Fellows program, PS39 Symposium information, and MORE! mailchi.mp/092ac32c4994...

Lund University, Sweden, is recruiting an Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy lu.varbi.com/en/what:job/... #NMRjobs #NMRchat #NMR #chemsky 🧲

🔊 ‼️Last days to apply for #PhD position to combat climate change in a Max Planck & University Consortium 📅 Deadline 09.03 📅 We are looking for chemistry students with a strong multi-step synthesis background in organic chemistry. Application online 📩 Please RT - Thanks!

Now published! Read our newest story! doi.org/10.1038/s414...