Desorden intrínseco en proteínas, multivalencia y multimerización RevistaSEBBM 229junio2026 por @xsalvatella1.bsky.social  No todas las proteínas funcionan desde una estructura fija. @irbbarcelona.org  https://f.mtr.cool/mvwgjybijj

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

Design and structure of protein cages based on helical fusion and machine learning www.biorxiv.org/content/10.64898/2026.05.27.727936v1 #cryoem

Memorial Minute for Martin Karplus - Harvard Gazette news.harvard.edu/gazette/stor... #NMRchat 🧲

Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇

4th Workshop on Structural Biophysics, October 12-16, 2026, Bordeaux, France, registration closes May 19 www.cbmn.u-bordeaux.fr/ivth-worksho... #NMRchat 🧲

Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...

Join Stanford Chem for this year's McConnell Lecturer in Chem: Prof. Lewis E. Kay (Univ. of Toronto), a pioneer in biomolecular NMR. He’ll present “The Essentiality of Solution NMR Spectroscopy in the Post-Alpha Fold Era,” May 5, 3–4 PM, Sapp Center 114. chemistry.stanford.edu/events/mccon...

🧬 Mutations in the "translators" of the human cell alter the reading of the genetic code in #cancer and #aging. ✍️ Lluís Ribas (#IRBBarcelona) et al. 📰 @genomeresearch.bsky.social#cancer#aging.#IRBBarcelona)ead more ➡️ https://shorturl.at/5pk2P 📌 DOI: 10.1101/gr.281022.125 #IRBScience #AgeingResearch #AgingResearch 🧪

Does AlphaFold’s latent space encode only the native state or something like a distribution over conformations? We begin to answer this question with ConforNets, a mechanism for producing diverse states, or very specific ones, via inference-time adaption of OF3p’s latent space👇

El nou edifici que acolllirà grups de recerca de 5 centres #BISTCommunity i enfocat en medicina de precisió va prenent forma. 👉https://www.ara.cat/societat/horitzo-2028-gran-hub-biomedicina-sud-d-europa-pren-forma_1_5702563.html?giveAway=uCQdvPiwpW4GkqLE

🔬A new mechanism explains how protein production is regulated in #FattyLiver under metabolic stress. 📰 Science Advances ✍️ Raúl Méndez, Eulàlia Belloc, Vittorio Calderone, Mercedes Fernández, @idibaps.bsky.social @ptck72.bsky.social et al. ➡️ https://shorturl.at/UtRVB 📌 DOI: 10.1126/sciadv.aea4125

Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances. www.science.org/doi/10.1126/... A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

📢 We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky

#paper #highlight February 2026 Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule By S. Bielskutė-García et al in #ScienceAdvances sbe.es/highlights-p... @xsalvatella1.bsky.social @irbbarcelona.org @icreacommunity.bsky.social

📢 Upcoming Seminar | Join us for a plenary seminar this Friday, with Dr. @adelaljord.bsky.social, from the @crg.eu. 🤝 Hosted by Dr. @xsalvatella1.bsky.social  Register here ➡️ https://shorturl.at/A9VMZ #IRBBarcelona #Seminar

Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!

Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation link.springer.com/article/10.1...

In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT

An excellent review on a fascinating topic !

Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve

📢  #MAINFRAME Symposium comes to Barcelona! Experts in #AI, computational chemistry & small-molecule #DrugDiscovery meet to advance open, large-scale screening for 2,000+ human proteins. 📆 Mar 18–19 📍 Ateneu Barcelonès ℹ️ https://shorturl.at/1aKKS @ptck72.bsky.social

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...

How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

You can’t miss this video we shared today during the tribute to Dr. #JoanGuinovart. Today, the scientific community, institutional leaders, colleagues, friends, and family gathers to honour the life and legacy of the founder and first director of #IRBBarcelona. 🎥 youtu.be/_SJ5Rudj2ik

📌 Don't miss our plenary #seminar this week, with Prof. Edward Lemke, from @unimainz.bsky.social.  Host: Dr. @xsalvatella1.bsky.social#seminar #IRBBarcelona Register here ➡️ https://shorturl.at/I58yN 🧪

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

I'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se

Thank you Fundación @bbvaenespana.bsky.social for supporting our collaboration with Michael Krieg of @icfo.eu !

Antoni Gaudí’s vision for the Sagrada Família, a church that’s been under construction for nearly 150 years, was never universally liked. George Orwell called the church “one of the most hideous buildings in the world.”

RFK Jr has vowed to find out what’s responsible for the rise in autism diagnoses, but scientists say he is ignoring answers from decades of research go.nature.com/47R4brs

Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out: eeik.fa.us2.oraclecloud.com/hcmUI/Candid... Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.

New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute. www.crg.eu/en/news/moni...

Congratulations to RSC-ESR group committee member Adam Brookfield and his colleague, Dr Muralidharan Shanmugam, for winning the RSC Technical Excellence Prize for their operations of the EPSRC NRF for EPR in Manchester, UK. www.manchester.ac.uk/about/news/f...

🏆 La investigación sobre la causa del #autismo, premio #VanguardiadelaCiencia 2025! ¡Enhorabuena a las premiadas: Dra. Carla Garcia Cabau y Dra. Anna Bartomeu, del #IRBBarcelona!👏👏👏 ➡️ https://shorturl.at/1hXF0 @lavanguardia.com @xsalvatella1.bsky.social  🧪

Today’s uniquely challenging biotech climate may result in a more resilient sector nature.com/articles/s41... rdcu.be/etg7h

“What is common knowledge in your field, but shocks outsiders?” Most drugs have several activities in the human body, and discovery of these effects goes on for years after they are on the market.

...the amino-acid sequence does not necessarily determine 3D shape, because many of our proteins have functionally crucial disordered regions that don't really have a shape. (Sometimes they fold on binding, perhaps in a ligand-specific way, sometimes they don't.)...

Here's an anniversary worth celebrating!

Patent departments have budget targets that lead to “pound foolish” decisions to abandon all the time.

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...

Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42... Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran... @irbbarcelona.org @xsalvatella1.bsky.social

The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...

Looking for a senior lecturer (associate #professor) position in #biochemistry? Come and join our neighbouring department at Uppsala University: www.uu.se/en/about-uu/...

The Structural Biology and NMR Laboratory—or SBiNLab as we call it—is turning 25 🎉🧲🇩🇰 We're celebrating with a symposium on Aug. 23 that is free and open to all Great speakers incl. Ad Bax, Frauke Gräter, Harald Schwalbe, Sarah Shammas, Mikael Akke & alumni! Join us: www1.bio.ku.dk/english/rese...