Our new Trends in Neurosciences review explores how nuclear speckles—dynamic nuclear condensates once thought to be passive splicing hubs—coordinate RNA metabolism, stress responses,and proteostasis, and how their dysfunction contributes to neurodegeneration. authors.elsevier.com/a/1mjZRbotqB...

link.springer.com/article/10.1.... Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!

It was a great please to share our most recent work on ‘rejuvenating’ nuclear speckles to alleviate proteinopathies. www.nature.com/articles/s41...

www.pittmed.pitt.edu/news/12-hour.... It is a nice news piece on our earlier work demonstrating the existence of 12h rhythms in ‘free-living’ humans.

It is a great review!!