How is the integrated stress response terminated? @annebertolotti.bsky.social’s group have revealed the mechanism of termination of the ISR, answering a decades-old question surrounding the ISR pathway, which is crucial to cellular homeostasis. www2.mrc-lmb.cam.ac.uk/how-is-the-i... #LMBReserch

Thank you so much for the opportunity to attend your talk at the IBFG 🙌. It was truly inspiring! ✨👏 @palconh.bsky.social

Very grateful to the Danish Cancer Society and our MBG colleagues for their support! This grant will enable us to expand our research scope and grow our team. mbg.au.dk/en/news-and-...

So excited to visit Salamanca this week!

Extraordinary Seminar at the IBFG! 📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark) 🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action 🗓 Nov 14, 2025 – 12:00 PM 📍 IBFG Auditorium, Salamanca

Ha muerto Antonio García-Bellido, uno de los mejores científicos de la historia de España tras descubrir las fronteras invisibles dentro de los seres vivos: elpais.com/ciencia/2025...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

Before her (too early) death, the amazing Sharon Begley wrote this piece on double helix co-discoverer James Watson and the racist and sexist pronouncements he seemed to revel in making in later life. Fascinating read about a troubling individual. www.statnews.com/2025/11/07/j...

I asked him what was the most important thing he ever did. He replied “opposing the patenting of human genes”. For a full picture of Jim, his terrible flaws and his insights, we will have to wait for @nccomfort.bsky.social’s forthcoming biography.

Our PLAMseq paper is out today in @ScienceAdvances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci. www.science.org/doi/10.1126/...

Excited to share our discovery of the RAD51 filament cap, built by a newly identified RAD51 paralog complex 🔬🧬

New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

🧵 Our latest preprint is available. It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism. Read more here 👉 www.medrxiv.org/content/10.1...

UK publication day for this wrist-spraining beauty! Appropriately, I’m travelling to Cambridge, where I’m doing a book launch talk at the LMB tomorrow afternoon.

Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays www.biorxiv.org/content/10.1101/2025.11.04.686567v1 #cryoem

The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors! Phosphorylation-dependent tuning of mRNA deadenylation rates www.nature.com/articles/s41...

📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

Thrilled to see Leyre’s PhD work finally out! We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬 www.nature.com/articles/s41...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

#womeninSTEM #womeninscience #Nobelprize Trading cards to share, print and collect cc @francesarnold.bsky.social @carolynbertozzi.bskyverified.social @jenniferdoudna.bsky.social @e-charpentier.bsky.social link (aninfinityofhypotheses.wordpress.com/wp-content/u...)

We still can’t predict much of anything in biology blog.genesmindsmachines.com/p/we-still-c...

🧬 Preprint alert! "Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity." Read the manuscript here 👉 www.biorxiv.org/content/10.1...

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

RIP John Gurdon

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

Congrats to #LMBAlumni Juan B. Rodriguez Molina, former Investigator Scientist in the LMB's Structural Studies Division, newly appointed Assistant Professor in the Dept of Molecular and Cellular Biosciences at the University of Cincinnati College of Medicine researchdirectory.uc.edu/p/1818215

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

I’m biased 🇩🇰, but this is quite nice to read: I thought science hinged on prestige. Moving abroad made me reassess my priorities www.science.org/content/arti...

1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer

News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

Nice corner. Spotted in Copenhagen.

Aarhus University to award five honorary doctorates medarbejdere.au.dk/en/news-arti...

Private tour of the Louvre is a special treat. They were vacuuming the Sphinx. You may not have seen a Sphinx being brushed, so I am sharing.

COngrats Juan!! To all interested: don't miss this opportunity to join Juan's lab, a great scientist and mentor! 🧬🔬🧫

@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

A tribute to Pedro Cuatrecasas, the Spaniard who (whilst working in the US) co-invented affinity chromatography.

Sebastian Balch, Zala Sekne & Elsa Franco-Echevarría in @kellythd-nguyen.bsky.social's group have confirmed the existence of dimeric telomerase and illustrated how it is key to telomere maintenance: www2.mrc-lmb.cam.ac.uk/first-struct... #LMBResearch @yiliangding.bsky.social @rdaslab.bsky.social 🧪

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Wish I could be there! An unmissable chance to hear Richard Henderson speak in the magical setting of Fonseca, Salamanca. ❄️⚡🔬

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

These NPG spinoff journals are out of control

Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB. In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. 🧵🔽 #TBsky #MicroSky #TB