Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️

So proud of my lab mate @ericmulhall.bsky.social and honored to help with this amazing project he led using MINFLUX to study why PIEZO2 behaves differently than PIEZO1 from the lab of @ardemp.bskyverified.social share.google/2Uln5O5OyqhM...

Preliminary Valentine's data from my postdoc work with @ardemp.bskyverified.social - RNAscope of Piezo2 transcript (green) and a nociceptor marker (magenta) in a mouse dorsal root ganglion 💜

🧠⚡️💊New @nature.com publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41... @pennmedicine.bsky.social

Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social www.cell.com/cell/fulltex... @cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social

A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.

Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...

This is not looking good for early career researchers, or any researchers.

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

First ION lab Halloween! Left to right: Mint Spice (TRPM8), Ginger Spice (TRPA1), Bactrachotoxin Spice (NaV), Capsaicin Spice (TRPV1) 🧊 🧄 🐸 🌶️

Guess which TRP channel agonist I dressed as? Honored to stand next to my childhood hero @jesshebert.bsky.social Ms. Frizzle

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Zara Weinberg was a brilliant light both in and out of science. She changed the lives of everyone she interacted and loved for the better. Her legacy will live on through all of us and we will fight for a better world on behalf of her memory.

A tour de force study by my colleague Tianyi Mao's lab @volluminstitute.bsky.social. Must read if one is interested in interoception, the insular cortex, or circuit architecture of associative cortices. www.biorxiv.org/content/10.1...

Meet the real rainbow fish 🌈🐟 Using Cre-mediated recombination, each zebrafish cell expresses a unique fluorescent color, creating a living rainbow of developmental history 🎨✨ Image by Bret Pearson #FluorescenceFriday #Zebrafish #DevBio

University administration: "We need you to complete 26 hours of lab safety training 🧪 each year so that everyone is safe and responsible." Also university administration:

I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!

I remember discussing the scurfy mouse in immunology class, which initially arose from basic research done at a national lab with government funds (Oak Ridge NL, near where my father grew up)...what an important finding to earn this year's Nobel Prize.

Congratulations to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for this year's Nobel Prize in Physiology or Medicine. It also demonstrates the fairness of the prize, as Mary Brunkow is a Senior Program Manager (not a professor) at the @isbscience.org hood.isbscience.org/people/mary-...

Sharing this excellent review now out from postdoc Sarah McLarnon! Lots of useful info on 3D imaging, quantification of imaging data, and how this has been applied to the kidney. And since it's #FluorescenceFriday, sharing a figure with our own imaging data! www.sciencedirect.com/science/arti...

Check out our resource for navigating and analyzing spatial transcriptomics data in the thalamus, which we fondly call "the THALMANAC" (𝐓𝐇𝐀𝐋amus 𝐌ERFISH 𝐀𝐍alysis and 𝐀𝐂cess), now live on bioRxiv: www.biorxiv.org/content/10.1...

We’re hiring! My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease. 🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...

Huge news! The Moayedi Lab has officially received their first R01 grant to study the neural mechanisms of astringency transduction and sensation! Can we get a whoop whoop hooray?! 🥳🎉🪩 @yaldamoayedi.bsky.social

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

Newest paper from the lab, looking at how somatosensory neuron development and function is altered in a Pten haploinsufficient model of ASD. Work was all done by @alefdzphd.bsky.social, who just started an independent position at UTRGV. onlinelibrary.wiley.com/doi/10.1002/...

I'm thrilled and honored to share that I've received a @simonsfoundation.org Fellows-to-Faculty award for my research on autism heterogeneity! Incredibly grateful for the support as I transition to tenure-track professorship 🧠 www.simonsfoundation.org/2025/09/16/s...

Celebrating good news for the lab (Janelle's fellowship and Lily's PROPEL acceptance). So proud of our awesome team!

Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW! facultycareers-ohsu.icims.com/jobs/35624/c...

My Ph.D. advisor taught me to celebrate upon submission. And re-submission. Or in this case, re-re-re-re-re-resubmission.

Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines. tryptyr.myalcon.com?gad_source=1...

Our August issue focuses on the under-recognized risk of cognitive impairment and dementia in people with chronic kidney disease. #CKD go.nature.com/4lzzMRW

Its very easy to feel defeated these days. Getting to see what our HEAL K12 scholars have achieved is a much needed boost. The future of pain medicine is strong :)

A beautifully written piece on a terrible time www.science.org/content/arti...

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

There is no better feeling than to see people in your lab succeed!

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

Our review on kidney sensory innervation is out! It was such an honor to write about all the amazing work from my colleagues in this growing field of renal interoception. Yay kidneys! www.sciencedirect.com/science/arti...

First dorsal root ganglion prep of the new lab, a few logistical hiccups but we have cultured neurons! Thanks to the colleagues who let me borrow so many things!

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...

an exciting time to receive your start-up funds 💸

Happy 2nd Annual International Mechanotransduction Day! May the 4th be with you. h/t Jeff Holt

And that's a wrap at Scripps! (literally). It was a wild 5.5 years through COVID, amazing science and colleagues, entering a new field, and a successful job search. I am grateful for the mentorship and opportunities I had with @ardemp.bskyverified.social. Here's to brighter days after the storm. 🥂

Welcome aboard, Dr Hill! cc: @rose-hill.bsky.social

Starting in one hour! Don’t miss your chance to learn more about the #SfN25 nanosymposium process in this free webinar hosted by SfN. Register now! bit.ly/42ojJjx

Also an update for those who asked, yes the P-97 micropipette puller I took to Portland from SD in my car survived and is working. The box filament didn't even shift alignment.

spectacular movie of a growing neuron

ionlaboratory.com Our lab website is live! 🧪 Life is good at OHSU CPB, @volluminstitute.bsky.social and Nephrology!

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

Folks, while much of the attention is on Harvard and Columbia's response to the Trump/Musk/RFK Jr. administration, I'd like to point out how #NIH terminations and funding cuts go far beyond this war with the nations' elite universities. 🧵🧪