The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus https://www.biorxiv.org/content/10.1101/2025.11.03.686433v1

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...

New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1

Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border https://www.biorxiv.org/content/10.1101/2025.10.03.680132v1

Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets https://www.biorxiv.org/content/10.1101/2025.09.20.677124v1

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Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...

Newest paper from the lab, looking at how somatosensory neuron development and function is altered in a Pten haploinsufficient model of ASD. Work was all done by @alefdzphd.bsky.social, who just started an independent position at UTRGV. onlinelibrary.wiley.com/doi/10.1002/...

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...

Very important @nicolettapetridou.bsky.social‬ report #mechanochemical signalling control fate transitions www.biorxiv.org/content/10.1... w/ wide/significant implications. Perhaps the clearest indication so far of HOW #NotInTheGenes cell interactions mechanical pattern gene expression #MustRead

We developed a transgene-free method to isolate neural crest cells using antibody labelling + FACS — tested in Podarcis muralis. It works as well as transgenic tools, opening doors for NCC research in non-model species! Link in comment. #DevBio #scRNAseq #NeuralCrest #EvoDevo

Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...

My Penn Biostatistics colleague Mingyao Li & two of our Biostatistics PhD students, Kyle Coleman & Shunzhou Jiang, have helped co-lead a new article published in Nature presenting spatial single cell transcriptomic characterization of brains of developing fetuses www.nature.com/articles/s41...

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

Some exciting #PainResearch / #Neuroskyence from @alexchesler.bsky.social & co!

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Baffling… It’s like cutting off one leg because you find shoes expensive.

Hey #deconvolution fans! 👀 We’ve got an exciting new publication for you: a benchmark of 6 popular deconvolution methods on a multimodal human brain #DLPFC dataset 🧠🧬 Now out in Genome Biology: doi.org/10.1186/s130... @lieberinstitute.bsky.social @jhubiostat.bsky.social

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...

Turns out LLMs can’t really write your code for you 🤷🏻‍♀️

We are using CUT&RUN-LoV-U to map effectors of Signaling Pathways across tissue and stages of Mouse #DevBio🐭🧬 Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS? www.biorxiv.org/content/10.1...

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

Check out my postdoc work at Ariel Levine’s lab, hot and fresh, describing how you build a dorsal horn! www.biorxiv.org/content/10.1...

🚨 New paper on ArXiv: “Uncertainty quantification and posterior sampling for network reconstruction” TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics. Short thread: 1/N

Harp: Platform Independent Deconvolution Tool www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/spang-lab/harp #Rstats#Rstats

Very cool!

⭐️ Join us for the 2025 Neurotrophic Mechanisms in Health and Disease GRS/GRC (May 31- Jun 6)⭐️. I am excited to be co-chairing the GRS and it is a great opportunity for postdocs and grad students. Apply by March 15th to be considered to give a talk. See you all there! www.grc.org/neurotrophic...

Thrilled to share the most recent pub from the Griffith Lab! We show that sodium channels play unique roles in proprioceptive encoding. We also found some really cool effects on skeletal muscle, and a dev dependent role for Nav1.6 in proprioceptive spinal circuits www.science.org/doi/10.1126/...

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.1101/2024.12.11.627935v1

@aliibarry.bsky.social ‘s excellent work on human DRG proteomics is now online. Collaboration between our lab and Manuela Schmidt’s lab in Austria. Ali’s multiomic integration analysis leads to some unique new insight into pain mechanisms with strong proteomic support.

Think this s cool? Keep reading this 🧵 DHARANI A 3D Developing Human-brain Atlas as a Resource to Advance Neuroscience Internationally Integrated Multimodal Imaging and High-resolution Histology

BOOM! Identification of a PIEZO2+, KIT+, and TRPM8+ A fiber nociceptor subtype that is responsible for human hair pull pain: www.researchsquare.com/article/rs-5... @saadnagi.bsky.social and colleagues, well done!

Welcome to BlueSky @anninaschmid.bsky.social ! Congrats again on your beautiful paper on human peripheral neuropathy - my current favourite 🧪🥳! #PainResearch #painscience #neuroskyence journals.lww.com/pain/fulltex...

Awesome work! and much needed. How else could people do downstream analysis on publicly available datasets? … Definitively a priority!

Looking much forward to it! 🧪 #devbio #collaborate #evodevo #zebrafish #represent

Good news everyone! A new version of graph-tool is just out! @graph-tool.skewed.de graph-tool.skewed.de Graph-tool is a comprehensive and efficient Python library to work with networks, including structural, dynamical, and statistical algorithms, as well as visualization. 1/N #networkscience

Learning on graphs 2024 recordings are all available online: youtube.com/watch?v=Af-_... logconference.org what a great resource!

🚀 It's #FluorescenceFriday, and commissural axons are coming at you! 🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse). One stack taken every 10 minutes. Pixels were color-coded in the z-axis. #LiveImaging #Neuroscience #Science #Microscopy 🧠✨

(1) How can we build complex structures from a limited set of progenitors and cell types? In our new preprint, we describe patterns of cell fate decisions during early development and (in some cases) identify molecular correlates of different behaviors. www.biorxiv.org/content/10.1...

This is a tortoise embryo after 30 days of development within its egg - check out its beating heart 🫀 🧪

Starting the week strong! Cheering myself up for the next challenges with 15 min of axonal growth cone dynamic madness. F-actin (cyan) and membrane (magenta) show their dance. One image taken every 10 s.🧠🔬 #MicroscopyMonday #LiveImaging #Neuroscience #Microscopy

If you use Jupyter Notebooks for #ImageAnalysis and would like to explore segmented objects side-by-side with measured features, try out #stackview clusterplot 🖥️🤓 github.com/haesleinhuep...

Happy #FluorescenceFriday ! Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo. #neuroscience #microscopy

How do LLMs learn to reason from data? Are they ~retrieving the answers from parametric knowledge🦜? In our new preprint, we look at the pretraining data and find evidence against this: Procedural knowledge in pretraining drives LLM reasoning ⚙️🔢 🧵⬇️

This is wild! 🤩

Another example of sparse autoencoders being used for interpretability studies of protein language models. Here, the authors take things a step further and use LLM Claude Sonnet 3.5 to describe en masse what all ~2.5k identified features could be www.biorxiv.org/content/10.1...

Something that's been bugging me for a while in bioinformatics data analysis is this overreliance on packages, workflows and what's been called "cargo cult science". Can we have more conceptual thinking, more theory? Asking for what we really want to achieve and what we need to do gets us there.